ArticleJournal of diabetes investigation2016
Periodontitis aggravated pancreatic β-cell dysfunction in diabetic mice through interleukin-12 regulation on Klotho.
Article in Journal of diabetes investigation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 33 citations in OpenAlex.
- Single-cell RNA-seq and in vitro study reveal Fusobacterium nucleatum impairs β-cell identity in type 2 diabetes via the NF-κB-CDKN1C axis.Journal of translational medicine · 2026Article
- The Role of Klotho in Oral and Maxillofacial Diseases: Mechanisms and Research Progress.Biomolecules · 2025Review
- Connection between oral health and chronic diseases.MedComm · 2025Review
- More than just teeth: How oral health can affect the heart.American heart journal plus : cardiology research and practice · 2024Review
- Using 8-Hydroxy-2'-Deoxiguanosine (8-OHdG) as a Reliable Biomarker for Assessing Periodontal Disease Associated with Diabetes.International journal of molecular sciences · 2024Review
- Periodontitis as a promoting factor of T2D: current evidence and mechanisms.International journal of oral science · 2023Review
- High-Glucose Media Reduced the Viability and Induced Differential Pro-Inflammatory Cytokines in Human Periodontal Ligament Fibroblasts.Biomolecules · 2023Article
- Effects of periodontitis on cancer outcomes in the era of immunotherapy.The lancet. Healthy longevity · 2023Review
- Omega-3 Effects on Ligature-Induced Periodontitis in Rats with Fructose-Induced Metabolic Syndrome.Inflammation · 2023Article
- Bidirectional association between polycystic ovary syndrome and periodontal diseases.Frontiers in endocrinology · 2023Review
- Novel Insight into the Mechanisms of the Bidirectional Relationship between Diabetes and Periodontitis.Biomedicines · 2022Review
- Administration of α-Klotho Does Not Rescue Renal Anemia in Mice.Frontiers in pediatrics · 2022Article
- The Klotho protein supports redox balance and metabolic functions of cardiomyocytes during ischemia/reperfusion injury.Cardiology journal · 2022Article
- Association between metabolic syndrome and periodontitis: The role of lipids, inflammatory cytokines, altered host response, and the microbiome.Periodontology 2000 · 2021Review
- Application of Ligature-Induced Periodontitis in Mice to Explore the Molecular Mechanism of Periodontal Disease.International journal of molecular sciences · 2021Review
- Connection between Periodontitis-Induced Low-Grade Endotoxemia and Systemic Diseases: Neutrophils as Protagonists and Targets.International journal of molecular sciences · 2021Review
- Periodontal Disease: A Risk Factor for Diabetes and Cardiovascular Disease.International journal of molecular sciences · 2019Review
- Establishment of oral bacterial communities in germ-free mice and the influence of recipient age.Molecular oral microbiology · 2018Article
- Changes in expression of klotho affect physiological processes, diseases, and cancer.Iranian journal of basic medical sciences · 2018Review
- α-klotho and anemia in patients with chronic kidney disease patients: A new perspective.Experimental and therapeutic medicine · 2017Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
AIMS/
introductionRecent studies have shown that periodontitis can contribute to adipose tissue inflammation and subsequent systemic insulin resistance in the obese rat model. However, the related inflammatory mechanism is not yet clear. The present study aims to investigate the effects of periodontitis on the function of pancreatic β-cells with pro-inflammatory cytokines-related immune mechanism in a mouse model. MATERIALS AND
methodsC57BL/6-db/db and inbred C57BL/6 mice were chosen here to establish a mouse model with periodontitis, which was induced by ligatures for 8 weeks. Glucose-stimulated insulin secretion was introduced to evaluate the function of pancreatic islets and β-cells. Serum levels of pro-inflammatory cytokines and Klotho were also measured, and the correlation between immunostimulation and Klotho level was deeply investigated in vitro.
resultsPancreatic β-cell failure, with insulin resistance, was observed in db/db mice, while periodontitis could aggravate β-cell dysfunction-related features. Serum levels of interleukin (IL)-12 and Klotho showed a negatively synergistic change, whereas the expression of Klotho was also inhibited under IL-12 treatment in MIN6 β-cells or isolated islets. Furthermore, IL-12-induced immune stimulation and also decreased insulin secretion were proven to be reversed by Klotho overexpression.
conclusionsPeriodontitis aggravated pancreatic β-cell failure in diabetic mice. Further in vitro studies showed IL-12 regulation on Klotho, while Klotho also acted as an inhibitor on IL-12, indicating the potential of Klotho for preserving pancreatic β-cell function in diabetes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.