Evidence map›Paper›PMID 27330568›Full record

ArticleEuropean neurological review2013

Autoimmune Encephalitis.

Frank Leypoldt, Klaus-Peter Wandinger, Christian G Bien, Josep Dalmau

Open access · bronzeAbstract read
In one paragraph

Article in European neurological review, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
0.2field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 82 citations in OpenAlex.

  1. Article
  2. Autoimmune Encephalitis in Acute Care-Pathology, Diagnosis, and Management.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Antibody-Negative Autoimmune Encephalitis: A Single-Center Retrospective Analysis.Neurology(R) neuroimmunology & neuroinflammation · 2023
    Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 3 countries.

Frank LeypoldtPost doctoral Research Fellow, Catalan Institution for Research and Advanced Studies (ICREA), August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain; Junior Attending Physician, Department of Neurology, University Medical Centre Hamburg-Eppendorf, Germany.
Klaus-Peter WandingerAttending Physician, Institute of Clinical Chemistry, University Medical-Centre Schleswig-Holstein Campus Lübeck, Germany; Attending Physician, Department of Neurology, University Medical-Centre Schleswig-Holstein Campus Lübeck, Germany.
Christian G BienHead of Department, Epilepsy Centre Bethel, Mara-Clinic Bethel, Bielefeld, Germany.
Josep DalmauPost doctoral Research Fellow, Catalan Institution for Research and Advanced Studies (ICREA), August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain.
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer · ESHospital Clínic de Barcelona · ESUniversität Hamburg · DEUniversity Hospital Schleswig-Holstein · DE

Funding

Paraneoplastic Disorders of the CNS: Autoantigen ProfilingR01NS077851 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI DALMAU, JOSEP O. · 2011 to 2015
$1.9M
Autoimmunity Against Novel Antigens in Neuropsychiatric DysfunctionR01MH094741 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI BALICE-GORDON, RITA J., DALMAU, JOSEP O. · 2011 to 2014
$1.3M
NIMH NIH HHS R01 MH094741NINDS NIH HHS R01 NS077851
6 · The paper itself

Abstract

The term autoimmune encephalitis is used to describe a group of disorders characterised by symptoms of limbic and extra-limbic dysfunction occurring in association with antibodies against synaptic antigens and proteins localised on the neuronal cell surface. In recent years there has been a rapidly expanding knowledge of these syndromes resulting in a shift in clinical paradigms and new insights into pathogenic mechanisms. Since many patients respond well to immunosuppressive treatment, the recognition of these disorders is of utmost importance. In general, there are no brain-imaging modalities or biomarkers specific of these disorders other than the demonstration of the neuronal antibodies. A disease classification based on these antibodies provides information on prognosis and paraneoplastic aetiology. This article focuses on recent clinical advances, newly characterised antibodies and treatment approaches to these disorders.

Indexed as

AMPA receptor antibodyanti-NMDA-receptor encephalitisbasal ganglia encephalitisdopamine D2 receptor encephalitisEncephalitisGABA(b) receptor antibodyglycine receptor antibodyHashimoto encephalopathylimbic encephalitisneuronal surface antigen antibodySREATstiff-person-syndromesynaptic autoimmunityVGKC complex antibody

Identifiers

PMID27330568
PMCPMC4910513
OpenAlexW4237722204

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.