ArticleWorld journal of emergency surgery : WJES2016
International normalized ratio and serum C-reactive protein are feasible markers to predict complicated appendicitis.
Article in World journal of emergency surgery : WJES, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03723642 (Investigation of Oxidative Stress - Open Appendectomy), which is not on this map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Investigation of Oxidative Stress - Open Appendectomy (OAE) Versus Laparoscopic Appendectomy (LAE) in Childhood and Adolescence - A Pilot Study
Who cites it
10 citing papers in PubMed, 23 citations in OpenAlex.
- Complicated appendicitis: value of inflammatory markers based on EAES 2015 guidelines.Surgical endoscopy · 2025Article
- Acute Appendicitis in Children During War Conflict: Results from a Multicenter Study.Journal of clinical medicine · 2025Article
- C-Reactive Protein, International Normalized Ratio, and Fibrinogen in Diagnostic Scale of Complicated Acute Appendicitis.Clinics and practice · 2025Article
- Changes in the frequency, presentation and surgical outcomes of complicated appendicitis during the pandemic.Northern clinics of Istanbul · 2024Article
- Predicting complicated appendicitis is possible without the use of sectional imaging-presenting the NoCtApp score.International journal of colorectal disease · 2023Article
- Effectiveness of pre-operative routine blood tests in predicting complicated acute appendicitis.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2022Article
- Clinical characteristics of older Japanese patients with acute appendicitis: A post hoc analysis.Journal of general and family medicine · 2022Article
- Predictive Efficacy of Delta Neutrophil Index in Diagnosis of Acute and Complicated Appendicitis.Cureus · 2021Article
- An observational study of innate immune responses in patients with acute appendicitis.Scientific reports · 2020Observational
- Clinical prediction of complicated appendicitis: A case-control study utilizing logistic regression.World journal of clinical cases · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDiagnostic approach for complicated appendicitis is still controversial. We planned this study to analyze preoperative laboratory markers that may predict complications of appendicitis.
methodsPatients who underwent appendectomy were retrospectively recruited. They were divided into complicated appendicitis and non-complicated appendicitis groups and their preoperative laboratory results were reviewed.
resultsA total of 234 patients were included. Elevated international normalized ratio (INR) and serum C-reactive protein (CRP) were associated with complicated appendicitis (p = 0.001). On ROC curve analysis, area under the curve (AUC) of CRP and INR were 0.796 and 0.723, respectively.
conclusionsINR and CRP increased significantly in patients with complicated appendicitis. Further studies evaluating INR and CRP in patients undergoing conservative management for appendicitis are required.
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