Evidence map›Paper›PMID 27330489›Full record

ArticleIntegrative medicine (Encinitas, Calif.)2016

Anxiety and Methylenetetrahydrofolate Reductase Mutation Treated With S-Adenosyl Methionine and Methylated B Vitamins.

Shanna Anderson, Jacob Panka, Robin Rakobitsch, Kaitlin Tyre, Kerry Pulliam

Open access · greenAbstract readCase Reports
PubMed Full text at PMC
In one paragraph

Article in Integrative medicine (Encinitas, Calif.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Pharmacogenetic Testing in Treatment-resistant Panic Disorder: a Preliminary Analysis.Clinical practice and epidemiology in mental health : CP & EMH · 2024
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Shanna AndersonShanna Anderson, ba ; Jacob Panka, ba ; Robin Rakobitsch, ba ; and Kaitlin Tyre, ba , are students at the National College of Natural Medicine (NCNM) in Portland, Oregon. Kerry Pulliam, MD, is a family medicine practitioner in private practice in Portland, Oregon.
Jacob PankaShanna Anderson, ba ; Jacob Panka, ba ; Robin Rakobitsch, ba ; and Kaitlin Tyre, ba , are students at the National College of Natural Medicine (NCNM) in Portland, Oregon. Kerry Pulliam, MD, is a family medicine practitioner in private practice in Portland, Oregon.
Robin RakobitschShanna Anderson, ba ; Jacob Panka, ba ; Robin Rakobitsch, ba ; and Kaitlin Tyre, ba , are students at the National College of Natural Medicine (NCNM) in Portland, Oregon. Kerry Pulliam, MD, is a family medicine practitioner in private practice in Portland, Oregon.
Kaitlin TyreShanna Anderson, ba ; Jacob Panka, ba ; Robin Rakobitsch, ba ; and Kaitlin Tyre, ba , are students at the National College of Natural Medicine (NCNM) in Portland, Oregon. Kerry Pulliam, MD, is a family medicine practitioner in private practice in Portland, Oregon.
Kerry PulliamShanna Anderson, ba ; Jacob Panka, ba ; Robin Rakobitsch, ba ; and Kaitlin Tyre, ba , are students at the National College of Natural Medicine (NCNM) in Portland, Oregon. Kerry Pulliam, MD, is a family medicine practitioner in private practice in Portland, Oregon.
National University of Natural Medicine · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This case report highlights challenges faced in the clinical management of patients with methylenetetrahydrofolate reductase (MTHFR) gene mutations and the importance of precise dosage when recommending methylated B vitamins to compensate for deficiencies caused by the polymorphism or symptoms related to the polymorphism. It also underscores the importance of obtaining ongoing objective assessments of anxiety (eg, Patient Reported Outcomes Measurement Information System, or PROMIS) to help gauge patient response.

Identifiers

PMID27330489
PMCPMC4898281
OpenAlexW2460964913

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.