ArticleJournal of basic and clinical pharmacy2016
Antibacterial synergy of curcumin with antibiotics against biofilm producing clinical bacterial isolates.
Article in Journal of basic and clinical pharmacy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 129 citations in OpenAlex.
- Emerging roles of combined curcumin and berberine in disease modulation: a comprehensive review of mechanisms and therapeutic relevance.Molecular biology reports · 2026Review
- Curcumin shows promise as an adjunct in changing β-lactam susceptibility status of canine multidrug-resistant Staphylococcus pseudintermedius: an in vitro study.Veterinary research communications · 2026Article
- A review of phytochemicals targeting bacterial biofilm and quorum sensing pathways: molecular, microbiological, and mechanistic insights.Archives of microbiology · 2026Review
- Synergistic antibacterial activity of curcumin and phage against multidrug-resistant Acinetobacter baumannii.Scientific reports · 2025Article
- Comprehensive Overview of Antibacterial Drugs and Natural Antibacterial Compounds Found in Food Plants.Antibiotics (Basel, Switzerland) · 2025Review
- Polymeric Molecular Envelope Technology for Improved Therapeutics Efficacy: A Review.Current medicinal chemistry · 2025Review
- Combination Effect of Phenylalanine-Arginine-Beta-Naphthylamide and Curcumin on the Expression of theHealth science reports · 2024Article
- Antivirulence Effects of Trans-Resveratrol and Curcumin on Methicillin-ResistantLife (Basel, Switzerland) · 2024Article
- Enhancing the Bioavailability and Bioactivity of Curcumin for Disease Prevention and Treatment.Antioxidants (Basel, Switzerland) · 2024Review
- Staphopain mediated virulence and antibiotic resistance alteration in co-infection of Staphylococcus aureus and Pseudomonas aeruginosa: an animal model.BMC biotechnology · 2024Article
- Molecular Aspects of the Functioning of Pathogenic Bacteria Biofilm Based onInternational journal of molecular sciences · 2024Review
- Effect of Resveratrol and Curcumin on Gene Expression of Methicillin-ResistantJournal of microbiology and biotechnology · 2024Article
- In vitro study of nanoliposomes containing curcumin and doxycycline for enhanced antimicrobial photodynamic therapy against Aggregatibacter actinomycetemcomitans.Scientific reports · 2023Article
- Therapeutic potential of curcumin in ARDS and COVID-19.Clinical and experimental pharmacology & physiology · 2023Review
- Susceptibility of periodontal pathogens to a novel target-specific drug delivery system containing self-nanoemulsifying curcumin: An in vitro study.Journal of advanced periodontology & implant dentistry · 2023Article
- Combination drug strategies for biofilm eradication using synthetic and natural agents in KAPE pathogens.Frontiers in cellular and infection microbiology · 2023Review
- Functional liposome loaded curcumin for the treatment ofFrontiers in chemistry · 2023Article
- Demonstration of the efficacy of curcumin on carbapenem-resistant Pseudomonas aeruginosa with Galleria mellonella larvae model.Archives of microbiology · 2022Article
- An Overview of Biofilm Formation-Combating Strategies and Mechanisms of Action of Antibiofilm Agents.Life (Basel, Switzerland) · 2022Review
- Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe role of natural bioactive substances in treating infections has been rediscovered as bacterial resistance become common to most of the antibiotics. Curcumin is a bioactive substance from turmeric. Owing to antimicrobial properties, its prospect as an antibacterial agent is currently under focus. MATERIALS AND
methodsWe have evaluated the in vitro synergy of curcumin with antibiotics against sixty biofilm producing bacterial isolates. Congo red agar method was used to identify the biofilm producing isolates. Curcumin minimum inhibitory concentration (MIC) was determined by agar dilution method. Its antibiotic synergy was identified by the increase in disc diffusion zone size on Mueller-Hinton agar with 32 mg/L curcumin.
resultsThe mean MICs of curcumin against Gram-positive and Gram-negative isolates were 126.9 mg/L and 117.4 mg/L, respectively. Maximum synergy was observed with ciprofloxacin among Gram-positive and amikacin, gentamicin, and cefepime among Gram-negative isolates.
conclusionsCurcumin per se as well as in combination with other antibiotics has a demonstrable antibacterial action against biofilm producing bacterial isolates. It may have a beneficial role in supplementing antibiotic therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.