ArticleBiology letters2016
Effects of protein malnutrition on tolerance to helminth infection.
Article in Biology letters, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Environmental factors that regulate host-helminth interactions.Trends in parasitology · 2026Review
- Host resources and parasite traits interact to determine the optimal combination of host parasite-mitigation strategies.Ecology and evolution · 2024Article
- Starving for nutrients: anorexia during infection with parasites in broilers is affected by diet composition.Poultry science · 2022Article
- Growth, body condition and contest performance after early-life food restriction in a long-lived tropical fish.Ecology and evolution · 2021Article
- Embracing nature's complexity: Immunoparasitology in the wild.Seminars in immunology · 2021Review
- Supplemented nutrition decreases helminth burden and increases drug efficacy in a natural host-helminth system.Proceedings. Biological sciences · 2021Article
- Parasite-Mediated Anorexia and Nutrition Modulate Virulence Evolution.Integrative and comparative biology · 2019Article
- Exogenous glucocorticoids amplify the costs of infection by reducing resistance and tolerance, but effects are mitigated by co-infection.Proceedings. Biological sciences · 2019Article
- Fueling Defense: Effects of Resources on the Ecology and Evolution of Tolerance to Parasite Infection.Frontiers in immunology · 2018Review
- Chronic early life stress induced by limited bedding and nesting (LBN) material in rodents: critical considerations of methodology, outcomes and translational potential.Stress (Amsterdam, Netherlands) · 2017Article
- Parasites, nutrition, immune responses and biology of metabolic tissues.Parasite immunology · 2017Review
- Increased hepatic Th2 and Treg subsets are associated with biliary fibrosis in different strains of mice caused by Clonorchis sinensis.PloS one · 2017Article
- Environmental Enteropathy: Elusive but Significant Subclinical Abnormalities in Developing Countries.EBioMedicine · 2016Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Infection tolerance is the ability of a host to limit the health effects of a given parasite load. A few recent studies have demonstrated genetic variation for tolerance, but little is known about how environmental factors affect tolerance. Here, we used the intestinal nematode Heligmosomoides polygyrus in laboratory mice to test for effects of protein malnutrition on tolerance. We performed an experiment where two different mouse strains (CBA and BALB/c) were fed either adequate-protein food or low-protein food, and trickle-infected with different doses of H. polygyrus larvae during four weeks. We found that protein malnutrition decreases tolerance measured as intestinal barrier function, but only in one of the strains (BALB/c); that is, there was a host genotype-by-environment interaction for tolerance. We conclude that nutritional status can affect tolerance and that sensitivity of tolerance to malnutrition may differ between host genotypes.
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