ArticleScientific reports2016
Specification of jaw identity by the Hand2 transcription factor.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 33 citations in OpenAlex.
- A Twist1-regulated distal enhancer crucial for Alx1 gene expression and function during craniofacial development.Developmental biology · 2026Article
- Pharyngeal Airway Changes After Functional Orthodontic Treatment in Growing Class II Patients: A Retrospective Cephalometric Comparison of Twin Block, RPE and AMCOPLife (Basel, Switzerland) · 2025Article
- Twist1 Acts Upstream of the Dlx5-Hand2 Pathway to Pattern the Mammalian Jaw.Journal of dental research · 2025Article
- Assessing candidate DLX-regulated genes in the first pharyngeal arch of chick embryos.Developmental dynamics : an official publication of the American Association of Anatomists · 2025Article
- Pleiotropic function of Dlx5/6 in the development of mammalian vocal and auditory organs.PloS one · 2025Article
- A knock-in allele of Hand2 expressing Dre recombinase.Genesis (New York, N.Y. : 2000) · 2024Article
- Identification and characterization of Hand2 upstream genomic enhancers active in developing stomach and limbs.Developmental dynamics : an official publication of the American Association of Anatomists · 2024Article
- Endothelin signaling in development.Development (Cambridge, England) · 2023Review
- Shaping faces: genetic and epigenetic control of craniofacial morphogenesis.Nature reviews. Genetics · 2023Review
- Transcriptome sequencing of facial adipose tissue reveals alterations in mRNAs of hemifacial microsomia.Frontiers in pediatrics · 2023Article
- Disrupted tenogenesis in masseter as a potential cause of micrognathia.International journal of oral science · 2022Article
- Meis2 controls skeletal formation in the hyoid region.Frontiers in cell and developmental biology · 2022Article
- Conserved and unique transcriptional features of pharyngeal arches in the skate (Leucoraja erinacea) and evolution of the jaw.Molecular biology and evolution · 2021Article
- The Mandibular and Hyoid Arches-From Molecular Patterning to Shaping Bone and Cartilage.International journal of molecular sciences · 2021Review
- The Transcription Factor HAND1 Is Involved in Cortical Bone Mass through the Regulation of Collagen Expression.International journal of molecular sciences · 2020Article
- Gli3 utilizes Hand2 to synergistically regulate tissue-specific transcriptional networks.eLife · 2020Article
- Diverse Fate of an Enigmatic Structure: 200 Years of Meckel's Cartilage.Frontiers in cell and developmental biology · 2020Review
- Mandibular dysmorphology due to abnormal embryonic osteogenesis in FGFR2-related craniosynostosis mice.Disease models & mechanisms · 2019Article
- Negative regulation of endothelin signaling by SIX1 is required for proper maxillary development.Development (Cambridge, England) · 2017Article
- Identification of shared and unique gene families associated with oral clefts.International journal of oral science · 2017Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acquisition of the lower jaw (mandible) was evolutionarily important for jawed vertebrates. In humans, syndromic craniofacial malformations often accompany jaw anomalies. The basic helix-loop-helix transcription factor Hand2, which is conserved among jawed vertebrates, is expressed in the neural crest in the mandibular process but not in the maxillary process of the first branchial arch. Here, we provide evidence that Hand2 is sufficient for upper jaw (maxilla)-to-mandible transformation by regulating the expression of homeobox transcription factors in mice. Altered Hand2 expression in the neural crest transformed the maxillae into mandibles with duplicated Meckel's cartilage, which resulted in an absence of the secondary palate. In Hand2-overexpressing mutants, non-Hox homeobox transcription factors were dysregulated. These results suggest that Hand2 regulates mandibular development through downstream genes of Hand2 and is therefore a major determinant of jaw identity. Hand2 may have influenced the evolutionary acquisition of the mandible and secondary palate.
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