ReviewEmerging microbes & infections2016
Has Rift Valley fever virus evolved with increasing severity in human populations in East Africa?
Review in Emerging microbes & infections, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 64 citations in OpenAlex.
- Contemporary epidemiological data of Rift Valley fever virus in humans, mosquitoes and other animal species in Africa: A systematic review and meta-analysis.Veterinary medicine and science · 2023Pooled it
- Clinical manifestations of Rift Valley fever in humans: Systematic review and meta-analysis.PLoS neglected tropical diseases · 2022Pooled it
- A Scoping Review of African Health Histories from the Pre-Colonial to SDG Eras: Insights for Future Health Systems.Healthcare (Basel, Switzerland) · 2026Review
- Serologic Evidence of Circulation of Six Arboviruses (Dengue Virus, Chikungunya Virus, Zika Virus, Rift Valley Virus, Yellow Fever Virus, Crimean-Congo Hemorrhagic Fever Virus) in Four Regions of Burkina Faso, West Africa.Tropical medicine and infectious disease · 2025Article
- Rift Valley fever virus and Coxiella burnetii infections among febrile patients, Eastern Ethiopia.PLoS neglected tropical diseases · 2025Article
- Detection and Molecular Characterization of Rift Valley Fever Virus in Apparently Healthy Cattle in Uganda.Pathogens (Basel, Switzerland) · 2025Article
- Rift Valley fever: A zoonotic disease with global potential.Open veterinary journal · 2025Review
- Real-Time Polymerase Chain Reaction Systems for Detection and Differentiation of Unclassified Viruses of theMethods and protocols · 2025Article
- Achievement of one health multi-sectoral collaboration in containment of Rift Valley Fever outbreak, Sudan, Red Sea State 2019.European journal of public health · 2025Article
- The socioeconomic impacts of Rift Valley fever: A rapid review.PLoS neglected tropical diseases · 2024Review
- Severe morbidity and hospital-based mortality from Rift Valley fever disease between November 2017 and March 2020 among humans in Uganda.Virology journal · 2024Article
- Identification of a negative-strand RNA virus with natural plant and fungal hosts.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Safety and immunogenicity of a ChAdOx1 vaccine against Rift Valley fever in UK adults: an open-label, non-randomised, first-in-human phase 1 clinical trial.The Lancet. Infectious diseases · 2023Article
- Mechanistic insight into the efficient packaging of antigenomic S RNA into Rift Valley fever virus particles.Frontiers in cellular and infection microbiology · 2023Article
- Understanding knowledge, attitude and perception of Rift Valley fever in Baringo South, Kenya: A cross-sectional study.PLOS global public health · 2023Article
- Entomological survey of the potential vectors of Rift Valley fever virus and absence of detection of the virus genome from the vectors in various niches in the southern half of the Great Rift Valley of Ethiopia.Veterinary medicine and science · 2022Article
- Serological evidence of the circulation of the Rift Valley fever virus in sheep and goats slaughtered in Yaoundé, Cameroon.Veterinary medicine and science · 2022Article
- Tick-borne pathogens, including Crimean-Congo haemorrhagic fever virus, at livestock markets and slaughterhouses in western Kenya.Transboundary and emerging diseases · 2021Article
- Identification of Bunyamwera and Possible OtherThe American journal of tropical medicine and hygiene · 2020Article
- Rift Valley Fever: Important Considerations for Risk Mitigation and Future Outbreaks.Tropical medicine and infectious disease · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rift Valley fever (RVF) outbreaks have occurred across eastern Africa from 1912 to 2010 approximately every 4-15 years, most of which have not been accompanied by significant epidemics in human populations. However, human epidemics during RVF outbreaks in eastern Africa have involved 478 deaths in 1998, 1107 reported cases with 350 deaths from 2006 to 2007 and 1174 cases with 241 deaths in 2008. We review the history of RVF outbreaks in eastern Africa to identify the epidemiological factors that could have influenced its increasing severity in humans. Diverse ecological factors influence outbreak frequency, whereas virus evolution has a greater impact on its virulence in hosts. Several factors could have influenced the lack of information on RVF in humans during earlier outbreaks, but the explosive nature of human RVF epidemics in recent years mirrors the evolutionary trend of the virus. Comparisons between isolates from different outbreaks have revealed an accumulation of genetic mutations and genomic reassortments that have diversified RVF virus genomes over several decades. The threat to humans posed by the diversified RVF virus strains increases the potential public health and socioeconomic impacts of future outbreaks. Understanding the shifting RVF epidemiology as determined by its evolution is key to developing new strategies for outbreak mitigation and prevention of future human RVF casualties.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.