Trial reportBrain : a journal of neurology2016
Orthostatic tremor: a cerebellar pathology?
Trial report in Brain : a journal of neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 4 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- Tremor in multiple system atrophy: a systematic literature review.Journal of neural transmission (Vienna, Austria : 1996) · 2026Pooled it
- Clinical and Electrophysiological Heterogeneity of Orthostatic Tremor: An Individual Patient Data Analysis.Tremor and other hyperkinetic movements (New York, N.Y.) · 2026Pooled it
- Altered brain connectivity in hyperkinetic movement disorders: A review of resting-state fMRI.NeuroImage. Clinical · 2023Pooled it
- Deep brain stimulation in uncommon tremor disorders: indications, targets, and programming.Journal of neurology · 2018Pooled it
- Zona incerta deep-brain stimulation in orthostatic tremor: efficacy and mechanism of improvement.Journal of neurology · 2019Trial
- Increased susceptibility and volume reduction in deep brain nuclei in primary orthostatic tremor.BMJ neurology open · 2026Article
- Cortical response to proprioceptive stimulation in primary orthostatic tremor - a magnetoencephalography study.Clinical neurophysiology practice · 2025Article
- Measurement of Functional Brain Network Connectivity in People with Orthostatic Tremor.Brain sciences · 2024Article
- The Phenomenology of Primary Orthostatic Tremor.Movement disorders clinical practice · 2022Article
- Associated co-morbidities in a retrospective cohort of orthostatic tremor.Journal of neurology · 2021Article
- Transcranial Magnetic Stimulation in Tremor Syndromes: Pathophysiologic Insights and Therapeutic Role.Frontiers in neurology · 2021Review
- Ataxia Prevalence in Primary Orthostatic Tremor.Tremor and other hyperkinetic movements (New York, N.Y.) · 2020Article
- The gait disorder in primary orthostatic tremor.Journal of neurology · 2020Article
- Deep brain stimulation for orthostatic tremor: A single-center case series.Neurology. Clinical practice · 2020Article
- A data mining approach for classification of orthostatic and essential tremor based on MRI-derived brain volume and cortical thickness.Annals of clinical and translational neurology · 2019Article
- Diffusion tensor imaging in orthostatic tremor: a tract-based spatial statistics study.Annals of clinical and translational neurology · 2019Article
- Orthostatic tremor and behavioral frontotemporal dementia: a case report with 7 years of follow-up.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019Article
- Towards computerized diagnosis of neurological stance disorders: data mining and machine learning of posturography and sway.Journal of neurology · 2019Article
- Neuropathology and pathogenesis of extrapyramidal movement disorders: a critical update. II. Hyperkinetic disorders.Journal of neural transmission (Vienna, Austria : 1996) · 2019Review
- Fully automated leg tracking of Drosophila neurodegeneration models reveals distinct conserved movement signatures.PLoS biology · 2019Article
Corrections and comments
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Authors and funding
15 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
SEE MUTHURAMAN ET AL DOI101093/AWW164 FOR A SCIENTIFIC COMMENTARY ON THIS ARTICLE: Primary orthostatic tremor is characterized by high frequency tremor affecting the legs and trunk during the standing position. Cerebellar defects were suggested in orthostatic tremor without direct evidence. We aimed to characterize the anatomo-functional defects of the cerebellar motor pathways in orthostatic tremor. We used multimodal neuroimaging to compare 17 patients with orthostatic tremor and 17 age- and gender-matched healthy volunteers. Nine of the patients with orthostatic tremor underwent repetitive transcranial stimulation applied over the cerebellum during five consecutive days. We quantified the duration of standing position and tremor severity through electromyographic recordings. Compared to healthy volunteers, grey matter volume in patients with orthostatic tremor was (i) increased in the cerebellar vermis and correlated positively with the duration of the standing position; and (ii) increased in the supplementary motor area and decreased in the lateral cerebellum, which both correlated with the disease duration. Functional connectivity between the lateral cerebellum and the supplementary motor area was abnormally increased in patients with orthostatic tremor, and correlated positively with tremor severity. After repetitive transcranial stimulation, tremor severity and functional connectivity between the lateral cerebellum and the supplementary motor area were reduced. We provide an explanation for orthostatic tremor pathophysiology, and demonstrate the functional relevance of cerebello-thalamo-cortical connections in tremor related to cerebellar defects.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.