SynthesisHuman molecular genetics2016
Genome-wide association study of 40,000 individuals identifies two novel loci associated with bipolar disorder.
Abstract readMeta-Analysis
In one paragraph
Synthesis in Human molecular genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 112 papers, 4 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
112citing papers in PubMed, 4 pooled it
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
112 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology.Nature genetics · 2021Pooled it
- Independent replications and integrative analyses confirm TRANK1 as a susceptibility gene for bipolar disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Pooled it
- Genome-wide association study identifies 30 loci associated with bipolar disorder.Nature genetics · 2019Pooled it
- Common variants at 2q11.2, 8q21.3, and 11q13.2 are associated with major mood disorders.Translational psychiatry · 2017Pooled it
- Association of Polygenic Score for Schizophrenia and HLA Antigen and Inflammation Genes With Response to Lithium in Bipolar Affective Disorder: A Genome-Wide Association Study.JAMA psychiatry · 2018Trial
- Identification of comprehensive genetic factors, pathways, and shared genetic architecture of putamen volume in adolescent cohort.Translational psychiatry · 2026Article
- Does Toxoplasma gondii infection have a causal impact on human psychopathology? A Mendelian randomization analysis.PLoS pathogens · 2026Article
- Integrative multi-omics identifiesPsychological medicine · 2026Article
- Dysregulation of Hippo Signaling Pathway as a Convergent Mechanism Underlying Choroid Plexus Defects in Bipolar Disorder.bioRxiv : the preprint server for biology · 2026Article
- Genome-wide association study of delay discounting identifies 11 loci and reveals transdiagnostic associations across mental and physical health.Molecular psychiatry · 2026Article
- Single-cell Multiome Analysis of Chromatin State and Transcriptome in the Human Basal Ganglia.bioRxiv : the preprint server for biology · 2026Article
- Whole exome sequencing analysis of suicidal thoughts and behaviors in a veteran cohort implicates inflammatory pathways and genes previously associated with psychiatric and neurodegenerative diseases.Journal of affective disorders · 2026Article
- Epigenetic Mechanisms of Suicidal Behavior Formation: A Review.Medical journal of the Islamic Republic of Iran · 2026Review
- POU3F2 regulates canonical Wnt signalling via SOX13 and ADNP to expand the neural progenitor population.Brain : a journal of neurology · 2025Article
- Deciphering causality between social/physical activity and suicide attempt: evidence from Mendelian randomization.European archives of psychiatry and clinical neuroscience · 2025Article
- Artificial Intelligence-Based Methods and Omics for Mental Illness Diagnosis: A Review.Bioengineering (Basel, Switzerland) · 2025Review
- Fine-mapping genomic loci refines bipolar disorder risk genes.Nature neuroscience · 2025Article
- Identification of candidate genes associated with bipolar disorder by whole-exome sequencing of a Chinese multi-affected pedigree.BMC psychiatry · 2025Article
- Phenome-wide investigation of dietary and health outcomes associated with bitter taste receptor gene TAS2R38.European journal of nutrition · 2025Article
- PICK1 links KIBRA and AMPA receptor subunit GluA2 in coiled-coil-driven supramolecular complexes.The Journal of biological chemistry · 2025Article
52 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
139 authors.
Liping HouIntramural Research Program, National Institute of Mental Health, National Institutes of Health,U.S. Department of Health & Human Services, Bethesda, MD, USA.
Sarah E BergenDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Nirmala AkulaIntramural Research Program, National Institute of Mental Health, National Institutes of Health,U.S. Department of Health & Human Services, Bethesda, MD, USA.
Jie SongDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Christina M HultmanDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Mikael LandénInstitute of Neuroscience and Physiology, The Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden.
Mazda AdliDepartment of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Campus Charité Mitte, Berlin, Germany.
Martin AldaDepartment of Psychiatry, Dalhousie University, Halifax, Canada.
Raffaella ArdauUnit of Clinical Pharmacology, Hospital University Agency of Cagliari, Cagliari, Italy.
Bárbara AriasDepartment of Biologia Animal, Unitat d'Antropologia (Dp. Biología Animal), Facultat de Biologia and Institut de Biomedicina (IBUB), Universitat de Barcelona, CIBERSAM, Barcelona, Spain.
Jean-Michel AubryDepartment of Mental Health and Psychiatry, Mood Disorders Unit, Geneva University Hospitals, Geneva, Switzerland.
Lena BacklundDepartment of Molecular Medicine and Surgery, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.
Judith A BadnerDepartment of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL, USA.
Thomas B BarrettPortland Veterans Affairs Medical Center, Portland, OR, USA.
Michael BauerDepartment of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität, Dresden, Germany.
Bernhard T BauneDiscipline of Psychiatry, University of Adelaide, Adelaide, Australia.
Frank BellivierINSERM UMR-S 1144 - Université Paris Diderot. Pôle de Psychiatrie, AP-HP, Groupe Hospitalier Lariboisière-F. Widal, Paris, France.
Antonio BenabarreBipolar Disorder Program, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.
Susanne BengesserSpecial Outpatient Center for Bipolar Affective Disorder, Medical University of Graz, Graz, Austria.
Wade H BerrettiniDepartment of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA.
Abesh Kumar BhattacharjeeDepartment of Psychiatry, University of California San Diego, San Diego, CA, USA.
Joanna M BiernackaDepartment of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
Armin BirnerSpecial Outpatient Center for Bipolar Affective Disorder, Medical University of Graz, Graz, Austria.
Cinnamon S BlossScripps Translational Science Institute, La Jolla, CA, USA.
Clara Brichant-PetitjeanINSERM UMR-S 1144 - Université Paris Diderot. Pôle de Psychiatrie, AP-HP, Groupe Hospitalier Lariboisière-F. Widal, Paris, France.
Elise T BuiIntramural Research Program, National Institute of Mental Health, National Institutes of Health,U.S. Department of Health & Human Services, Bethesda, MD, USA.
William ByerleyDepartment of Psychiatry, University of California at San Francisco, San Francisco, CA, USA.
Pablo CervantesMcGill University Health Centre, Mood Disorders Program, Montreal, QC, Canada.
Caterina ChillottiUnit of Clinical Pharmacology, Hospital University Agency of Cagliari, Cagliari, Italy.
Sven CichonInstitute of Human Genetics, University of Bonn, Germany.
Francesc ColomBipolar Disorder Program, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.
William CoryellUniversity of Iowa Hospitals and Clinics, Iowa City, IA, USA.
David W CraigThe Translational Genomics Research Institute, Phoenix, AZ, USA.
Cristiana CruceanuDouglas Mental Health University Institute, McGill University, Montreal, Canada.
Piotr M CzerskiPsychiatric Genetic Unit, Poznan University of Medical Sciences, Poznan, Poland.
Tony DavisDiscipline of Psychiatry, University of Adelaide, Adelaide, Australia.
Alexandre DayerDepartment of Mental Health and Psychiatry, Mood Disorders Unit, Geneva University Hospitals, Geneva, Switzerland.
Franziska DegenhardtInstitute of Human Genetics, University of Bonn, Germany.
Maria Del ZompoDepartment of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
J Raymond DePauloDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Howard J EdenbergDepartment of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA.
Bruno ÉtainINSERM U955, Psychiatrie translationnelle, Université Paris Est Créteil, Pôle de Psychiatrie et d'Addictologie, Hôpitaux Universitaires Henri Mondor, Créteil, France.
Peter FalkaiDepartment of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Munich, Germany.
Tatiana ForoudDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.
Andreas J ForstnerInstitute of Human Genetics, University of Bonn, Germany.
Louise FrisénDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Mark A FryeDepartment of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA.
Janice M FullertonPsychiatric Genetics, Neuroscience Research Australia, Sydney, Australia.
Sébastien GardService de Psychiatrie, Hôpital Charles Perrens, Bordeaux, France.
Julie S GarnhamDepartment of Psychiatry, Dalhousie University, Halifax, Canada.
Elliot S GershonDepartment of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL, USA.
Fernando S GoesDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Tiffany A GreenwoodDepartment of Psychiatry, University of California San Diego, San Diego, CA, USA.
Maria Grigoroiu-SerbanescuBiometric Psychiatric Genetics Research Unit, Alexandru Obregia Clinical Psychiatric Hospital, Bucharest, Romania.
Joanna HauserPsychiatric Genetic Unit, Poznan University of Medical Sciences, Poznan, Poland.
Urs HeilbronnerInstitute of Psychiatric Phenomics and Genomics, Ludwig-Maximilians-University Munich, Munich, Germany.
Stefanie Heilmann-HeimbachInstitute of Human Genetics, University of Bonn, Germany.
Stefan HermsInstitute of Human Genetics, University of Bonn, Germany.
Maria HipolitoDepartment of Psychiatry and Behavioral Sciences, Howard University Hospital, Washington, DC, USA.
Shashi HitturlingappaDiscipline of Psychiatry, University of Adelaide, Adelaide, Australia.
Per HoffmannInstitute of Human Genetics, University of Bonn, Germany.
Andrea HofmannInstitute of Human Genetics, University of Bonn, Germany.
Stephane JamainINSERM U955, Psychiatrie translationnelle, Université Paris Est Créteil, Pôle de Psychiatrie et d'Addictologie, Hôpitaux Universitaires Henri Mondor, Créteil, France.
Esther JiménezBipolar Disorder Program, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.
Jean-Pierre KahnService de Psychiatrie et Psychologie Clinique, Centre Psychothérapique de Nancy - Université de Lorraine, Nancy, France.
Layla KassemIntramural Research Program, National Institute of Mental Health, National Institutes of Health,U.S. Department of Health & Human Services, Bethesda, MD, USA.
John R KelsoeDepartment of Psychiatry, University of California San Diego, San Diego, CA, USA.
Sarah Kittel-SchneiderDepartment of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt, Germany.
Sebastian KliwickiDepartment of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland.
Daniel L KollerDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.
Barbara KönigDepartment of Psychiatry and Psychotherapeuthic Medicine, Landesklinikum Neunkirchen, Neunkirchen, Austria.
Nina LacknerSpecial Outpatient Center for Bipolar Affective Disorder, Medical University of Graz, Graz, Austria.
Gonzalo LajeIntramural Research Program, National Institute of Mental Health, National Institutes of Health,U.S. Department of Health & Human Services, Bethesda, MD, USA.
Maren LangDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Catharina LavebrattDepartment of Molecular Medicine and Surgery, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.
William B LawsonDepartment of Psychiatry and Behavioral Sciences, Howard University Hospital, Washington, DC, USA.
Marion LeboyerINSERM U955, Psychiatrie translationnelle, Université Paris Est Créteil, Pôle de Psychiatrie et d'Addictologie, Hôpitaux Universitaires Henri Mondor, Créteil, France.
Susan G LeckbandDepartment of Pharmacy, VA San Diego Healthcare System, San Diego, CA, USA.
Chunyu LiuDepartment of Psychiatry, University of Illinois at Chicago, Chicago, IL, USA.
Anna MaaserInstitute of Human Genetics, University of Bonn, Germany.
Pamela B MahonDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Wolfgang MaierDepartment of Psychiatry, University of Bonn, Germany.
Mario MajDepartment of Psychiatry, University of Naples SUN, Naples, Italy.
Mirko ManchiaDepartment of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
Lina MartinssonDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Michael J McCarthyDepartment of Psychiatry, VA San Diego Healthcare System, San Diego, CA, USA.
Susan L McElroyLindner Center of HOPE, University of Cincinnati College of Medicine, Mason, OH, USA.
Melvin G McInnisDepartment of Psychiatry, University of Michigan, Ann Arbor, MI, USA.
Rebecca McKinneyDepartment of Psychiatry, University of California San Diego, San Diego, CA, USA.
Philip B MitchellSchool of Psychiatry, University of New South Wales, and Black Dog Institute, Sydney, Australia.
Marina MitjansDepartment of Biologia Animal, Unitat d'Antropologia (Dp. Biología Animal), Facultat de Biologia and Institut de Biomedicina (IBUB), Universitat de Barcelona, CIBERSAM, Barcelona, Spain.
Francis M MondimoreDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Palmiero MonteleoneDepartment of Psychiatry, University of Naples SUN, Naples, Italy.
Thomas W MühleisenInstitute of Human Genetics, University of Bonn, Germany.
Caroline M NievergeltDepartment of Psychiatry, University of California San Diego, San Diego, CA, USA.
Markus M NöthenInstitute of Human Genetics, University of Bonn, Germany.
Tomas NovákNational Institute of Mental Health, Klecany, Czech Republic.
John I NurnbergerDepartment of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA.
Evaristus A NwuliaDepartment of Psychiatry and Behavioral Sciences, Howard University Hospital, Washington, DC, USA.
Urban ÖsbyDepartment of Neurobiology, Care Sciences, and Society, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.
Andrea PfennigDepartment of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität, Dresden, Germany.
James B PotashDepartment of Psychiatry, Carver College of Medicine, University of Iowa School of Medicine, Iowa City, IA, USA.
Peter ProppingInstitute of Human Genetics, University of Bonn, Germany.
Andreas ReifDepartment of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt, Germany.
Eva ReininghausSpecial Outpatient Center for Bipolar Affective Disorder, Medical University of Graz, Graz, Austria.
John RiceDepartment of Psychiatry, Washington University School of Medicine in St. Louis.
Marcella RietschelDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Guy A RouleauMontreal Neurological Institute and Hospital, McGill University, Montreal, Canada.
Janusz K RybakowskiDepartment of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland.
Martin SchallingDepartment of Molecular Medicine and Surgery, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.
William A ScheftnerRush University Medical Center, Chicago, IL, USA.
Peter R SchofieldSchool of Medical Sciences, University of New South Wales, Sydney, NSW, 2052, Australia.
Nicholas J SchorkScripps Translational Science Institute, La Jolla, CA, USA.
Thomas G SchulzeIntramural Research Program, National Institute of Mental Health, National Institutes of Health,U.S. Department of Health & Human Services, Bethesda, MD, USA.
Johannes SchumacherInstitute of Human Genetics, University of Bonn, Germany.
Barbara W SchweizerDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Giovanni SeverinoDepartment of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
Tatyana ShekhtmanDepartment of Psychiatry, University of California San Diego, San Diego, CA, USA.
Paul D ShillingDepartment of Psychiatry, University of California San Diego, San Diego, CA, USA.
Christian SimhandlBipolar Center Wiener Neustadt, Wiener Neustadt, Austria and.
Claire M SlaneyDepartment of Psychiatry, Dalhousie University, Halifax, Canada.
Erin N SmithScripps Translational Science Institute, La Jolla, CA, USA.
Alessio SquassinaDepartment of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
Thomas StammDepartment of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Campus Charité Mitte, Berlin, Germany.
Pavla StopkovaNational Institute of Mental Health, Klecany, Czech Republic.
Fabian StreitDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Jana StrohmaierDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Szabolcs SzelingerThe Translational Genomics Research Institute, Phoenix, AZ, USA.
Sarah K TigheDepartment of Psychiatry, Carver College of Medicine, University of Iowa School of Medicine, Iowa City, IA, USA.
Alfonso TortorellaDepartment of Psychiatry, University of Naples SUN, Naples, Italy.
Gustavo TureckiDouglas Mental Health University Institute, McGill University, Montreal, Canada.
Eduard VietaBipolar Disorder Program, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.
Julia VolkertDepartment of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt, Germany.
Stephanie H WittDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Adam WrightSchool of Psychiatry, University of New South Wales, and Black Dog Institute, Sydney, Australia.
Peter P ZandiDepartment of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Peng ZhangDepartment of Psychiatry, University of Michigan, Ann Arbor, MI, USA.
Sebastian ZollnerDepartment of Psychiatry, University of Michigan, Ann Arbor, MI, USA.
Francis J McMahonIntramural Research Program, National Institute of Mental Health, National Institutes of Health,U.S. Department of Health & Human Services, Bethesda, MD, USA, mcmahonf@mail.nih.gov.
Funding
Mapping genes that contribute to bipolar disorderZIAMH002810 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI MCMAHON, FRANCIS J · 2009 to 2025
$31.2MIdentification of Genes Involved in Major Mood DisordersZIAMH002843 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI MCMAHON, FRANCIS J · 2009 to 2025
$24.5MIndiana Clinical and Translational Sciences InstituteUL1TR001108 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI DENNE, SCOTT C., SHEKHAR, ANANTHA · 2013 to 2017
$23.3MThe Collaborative Genetic Study of Nicotine DependenceP01CA089392 · NCI · WASHINGTON UNIVERSITY · PI BIERUT, LAURA J. · 2001 to 2012
$17.3MLIMBIC &MEDULLARY MECH. IN COCAINE-RELATED SUDDEN DEATHR01DA006227 · NIDA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI MASH, DEBORAH C. · 1990 to 2012
$3.7MEpigenetic Marks of Cocaine AddictionR01DA033684 · NIDA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI MASH, DEBORAH C., TURECKI, GUSTAVO · 2011 to 2015
$3.6MCOLLABORATIVE GENOMIC STUDY OF BIPOLAR DISORDERR01MH059534 · NIMH · WASHINGTON UNIVERSITY · PI RICE, JOHN P. · 1998 to 2007
$3.1MCOLLABORATIVE GENOMIC STUDY OF BIPOLAR DISORDERR01MH059545 · NIMH · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI NURNBERGER, JOHN I · 1998 to 2007
$2.6MCOLLABORATIVE GENOMIC STUDY OF BIPOLAR DISORDERR01MH059533 · NIMH · JOHNS HOPKINS UNIVERSITY · PI MACKINNON, DEAN FREDERICK · 1998 to 2007
$2.4MMethods for high-resolution analysis of genetic effects on gene expressionR01MH101814 · NIMH · UNIVERSITY OF GENEVA · PI BUSTAMANTE, CARLOS DANIEL, DERMITZAKIS, EMMANOUIL · 2013 to 2016
$2.3MHarnessing GTEx to Create Transcriptome Knowledge and Inform Disease BiologyR01MH101820 · NIMH · UNIVERSITY OF CHICAGO · PI COX, NANCY J, NICOLAE, DAN LIVIU · 2013 to 2015
$2.3MCOLLABORATIVE GENOMIC STUDY OF BIPOLAR DISORDERR01MH060068 · NIMH · UNIVERSITY OF CALIFORNIA IRVINE · PI BYERLEY, WILLIAM · 1998 to 2007
$2.1MCCR NIH HHS HHSN261200800001CIntramural NIH HHS Z01 MH002810NCATS NIH HHS UL1 TR001108NCI NIH HHS HHSN261200800001ENCI NIH HHS P01 CA089392NHLBI NIH HHS HHSN268201000029CNIDA NIH HHS K02 DA021237NIDA NIH HHS R01 DA006227NIDA NIH HHS R01 DA033684NIMH NIH HHS R01 MH059533NIMH NIH HHS R01 MH059534NIMH NIH HHS R01 MH059535NIMH NIH HHS R01 MH059545NIMH NIH HHS R01 MH059548NIMH NIH HHS R01 MH059553NIMH NIH HHS R01 MH059556NIMH NIH HHS R01 MH059567NIMH NIH HHS R01 MH060068NIMH NIH HHS R01 MH090936NIMH NIH HHS R01 MH090937NIMH NIH HHS R01 MH090941NIMH NIH HHS R01 MH090948NIMH NIH HHS R01 MH090951NIMH NIH HHS R01 MH101782NIMH NIH HHS R01 MH101810NIMH NIH HHS R01 MH101814NIMH NIH HHS R01 MH101819NIMH NIH HHS R01 MH101820NIMH NIH HHS R01 MH101822NIMH NIH HHS R01 MH101825Wellcome Trust
Abstract
Bipolar disorder (BD) is a genetically complex mental illness characterized by severe oscillations of mood and behaviour. Genome-wide association studies (GWAS) have identified several risk loci that together account for a small portion of the heritability. To identify additional risk loci, we performed a two-stage meta-analysis of >9 million genetic variants in 9,784 bipolar disorder patients and 30,471 controls, the largest GWAS of BD to date. In this study, to increase power we used ∼2,000 lithium-treated cases with a long-term diagnosis of BD from the Consortium on Lithium Genetics, excess controls, and analytic methods optimized for markers on the X-chromosome. In addition to four known loci, results revealed genome-wide significant associations at two novel loci: an intergenic region on 9p21.3 (rs12553324, P = 5.87 × 10
Indexed as
Genome-Wide Association StudyBipolar DisorderChromosomes, Human, XErb-b2 Receptor Tyrosine KinasesFemaleHumansMaleERBB2 protein, humanErb-b2 Receptor Tyrosine Kinases
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