ArticleThe Journal of pediatrics2016
Using Multiplex Molecular Testing to Determine the Etiology of Acute Gastroenteritis in Children.
Article in The Journal of pediatrics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Clinical Impact of Multiplex Molecular Diagnostic Testing in Children With Acute Gastroenteritis Presenting to an Emergency Department: A Multicenter Prospective Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024Trial
- Comparison of a Rapid Multiplex Gastrointestinal Panel with Standard Laboratory Testing in the Management of Children with Hematochezia in a Pediatric Emergency Department: Randomized Controlled Trial.Microbiology spectrum · 2023Trial
- A randomized trial evaluating virus-specific effects of a combination probiotic in children with acute gastroenteritis.Nature communications · 2020Trial
- Prevalence and Genetic Diversity of Adenovirus 40/41, Astrovirus, and Sapovirus in Children With Acute Gastroenteritis in Kansas City, 2011-2016.The Journal of infectious diseases · 2025Article
- Detection and Characterization of Bacterial and Viral Acute Gastroenteritis among Outpatient Children under 5 Years Old in Guangzhou, China.The American journal of tropical medicine and hygiene · 2024Article
- Variation in stool testing for children with acute gastrointestinal infections.Journal of hospital medicine · 2023Article
- Multiplex PCR Pathogen Detection in Acute Gastroenteritis Among Hospitalized US Children Compared With Healthy Controls During 2011-2016 in the Post-Rotavirus Vaccine Era.Open forum infectious diseases · 2021Article
- Two-step Testing for Clostridioides Difficile is Inadequate in Differentiating Infection From Colonization in Children.Journal of pediatric gastroenterology and nutrition · 2021Article
- The Changing Landscape of Pediatric Viral Enteropathogens in the Post-Rotavirus Vaccine Era.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Human Bocavirus in Brazil: Molecular Epidemiology, Viral Load and Co-Infections.Pathogens (Basel, Switzerland) · 2020Article
- Defining a Molecular Signature for Uropathogenic versus Urocolonizing Escherichia coli: The Status of the Field and New Clinical Opportunities.Journal of molecular biology · 2020Article
- Evaluation of viral co-infections among patients with community-associated Clostridioides difficile infection.PloS one · 2020Article
- Comparative Evaluation of Enteric Bacterial Culture and a Molecular Multiplex Syndromic Panel in Children with Acute Gastroenteritis.Journal of clinical microbiology · 2019Article
- Pigment Visibility on Rectal Swabs Used To Detect Enteropathogens: a Prospective Cohort Study.Journal of clinical microbiology · 2019Article
- The GenMark ePlexFuture microbiology · 2018Review
- Comparative Transcriptomic Response of Primary and Immortalized Macrophages to Murine Norovirus Infection.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Norovirus Loads in Stool Specimens of Cancer Patients with Norovirus Gastroenteritis.The Journal of molecular diagnostics : JMD · 2017Article
- Strategies for Optimizing the Diagnostic Predictive Value of Clostridium difficile Molecular Diagnostics.Journal of clinical microbiology · 2017Article
- Astrovirus Diagnostics.Viruses · 2017Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
objectiveTo detect the etiologic agents of acute gastroenteritis (AGE) in children using broad molecular-based techniques, and compare clinical presentations among etiologies. STUDY
designThis was a prospective population-based surveillance study of children aged <6 years with AGE conducted between 2008 and 2011 as part of the New Vaccine Surveillance Network. Stools from patients and healthy controls were tested for 21 gastrointestinal pathogens using the analyte-specific reagent Gastrointestinal Pathogen Panel and an additional reverse transcription real-time polymerase chain reaction assay for sapovirus and astrovirus.
resultsOf the 216 stool samples from patients with AGE, 152 (70.4%) tested positive for a pathogen, with norovirus genogroup II (n = 78; 36.1%) and Clostridium difficile (n = 35; 16.2%) the most common pathogens detected. Forty-nine patients (22.7%) tested positive for more than 1 pathogen, including 25 (71%) with a C difficile detection. There were no significant clinical differences among the patients with no pathogen detected, those with a single pathogen detected, and those with ≥2 pathogens detected.
conclusionUsing a broad molecular testing approach, high rates of enteropathogens were detected in children with AGE, dominated by norovirus genogroup II and C difficile. Coinfections were common but had no identifiable impact on clinical manifestations. As routine diagnostics of AGE progressively evolve toward nucleic acid-based pathogen detection, ongoing systematic studies are needed to better analyze the clinical significance of results.
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