Evidence map›Paper›PMID 27329438›Full record

ArticleBMJ open2016

Tranexamic acid in hip fracture patients: a protocol for a randomised, placebo controlled trial on the efficacy of tranexamic acid in reducing blood loss in hip fracture patients.

Elizabeth Bishop Gausden, Matthew R Garner, Stephen J Warner, Ashley Levack, Andrew M Nellestein, Tiffany Tedore, Eva Flores, Dean G Lorich

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01940536 (The Effect of Tranexamic Acid on Transfusion Rates in Intertrochanteric Hip Fractures), which is not on this map. Cited by 13 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 3 pooled it
1.9field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01940536 phase4withdrawnnot on this map

The Effect of Tranexamic Acid on Transfusion Rates in Intertrochanteric Hip Fractures: A Prospective, Double-Blind, Randomized Controlled Trial

TypeinterventionalSponsorHospital for Special Surgery, New YorkRan2015 to 2019Enrolled0ConditionsHip Fracture, Blood LossArmsTranexamic Acid, Placebo
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 3 syntheses or guidelines pooled it, 38 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Review
  6. Global mapping of institutional and hospital-based (Level II-IV) arthroplasty registries: a scoping review.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2024
    Article
  7. Article
  8. Article
  9. Article
  10. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Elizabeth Bishop GausdenDepartment of Orthopaedics, Hospital for Special Surgery, New York, New York, USA.
Matthew R GarnerDepartment of Orthopaedics, Harborview Medical Center, Seattle, Washington, USA.
Stephen J WarnerDepartment of Orthopaedics, Hospital for Special Surgery, New York, New York, USA.
Ashley LevackDepartment of Orthopaedics, Hospital for Special Surgery, New York, New York, USA.
Andrew M NellesteinDepartment of Orthopaedic Trauma, New York Presbyterian Hospital, New York, New York, USA.
Tiffany TedoreDepartment of Anesthesiology, New York Presbyterian Hospital, New York, New York, USA.
Eva FloresDepartment of Internal Medicine, New York Presbyterian Hospital, New York, New York, USA.
Dean G LorichDepartment of Orthopaedic Trauma, New York Presbyterian Hospital, New York, New York, USA.
NewYork–Presbyterian Hospital · USHospital for Special Surgery · USHarborview Medical Center · US

Funding

Center for Clinical and Translational Sciences (CCTS)UL1TR000371 · NCATS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MCPHERSON, DAVID D · 2012 to 2016
$13.4M
NCATS NIH HHS UL1 TR000371
6 · The paper itself

Abstract

introductionThere is a high incidence of blood transfusion following hip fractures in elderly patients. Tranexamic acid (TXA) has proven efficacy in decreasing blood loss in general trauma patients as well as patients undergoing elective orthopaedic surgery. A randomised controlled trial will measure the effect of TXA in a population of patients undergoing hip fracture surgery.

methodsThis is a double-blinded, randomised placebo-controlled trial. Patients admitted through the emergency room that are diagnosed with an intertrochanteric or femoral neck fracture will be eligible for enrolment and randomised to either treatment with 1 g of intravenous TXA or intravenous saline at the time of skin incision. Patients undergoing percutaneous intervention for non-displaced or minimally displaced femoral neck fractures will not be eligible for enrolment. Postoperative transfusion rates will be recorded and blood loss will be calculated from serial haematocrits. ETHICS AND DISSEMINATION: This protocol was approved by the Institutional Review Board (IRB) and is registered with clinicaltrials.gov. The findings of the trial will be disseminated through peer-reviewed journals and conference presentations. TRIAL REGISTRATION NUMBER: NCT01940536.

Indexed as

Arthroplasty, Replacement, HipAgedAntifibrinolytic AgentsBlood Loss, SurgicalBlood TransfusionClinical ProtocolsDouble-Blind MethodFemaleHip FracturesHumansTranexamic AcidTreatment OutcomeUnited StatesAntifibrinolytic AgentsTranexamic Acidblood transfusionhip fracturetranexamic acid

Identifiers

PMID27329438
PMCPMC4916621
OpenAlexW2460522178

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.