SynthesisHuman brain mapping2016
Neuroanatomical and neurofunctional markers of social cognition in autism spectrum disorder.
Synthesis in Human brain mapping, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
99 citing papers in PubMed, 8 syntheses or guidelines pooled it.
- Regional Brain Volume Differences Were Associated With Behavioural Outcomes in Children Born Preterm: A Systematic Review.Acta paediatrica (Oslo, Norway : 1992) · 2026Pooled it
- Naturalistic stimuli in neuroimaging studies of autism spectrum disorder: a systematic review.Frontiers in human neuroscience · 2026Pooled it
- Systematic review and meta-analysis: multimodal functional and anatomical neural alterations in autism spectrum disorder.Molecular autism · 2024Pooled it
- Coactivation of Autonomic and Central Nervous Systems During Processing of Socially Relevant Information in Autism Spectrum Disorder: A Systematic Review.Neuropsychology review · 2024Pooled it
- Gray matter covariations in autism: out-of-sample replication using the ENIGMA autism cohort.Molecular autism · 2024Pooled it
- An updated systematic review on the maternal exposure to environmental pesticides and involved mechanisms of autism spectrum disorder (ASD) progression risk in children.Reviews on environmental health · 2023Pooled it
- Meta-analytic connectivity modelling of functional magnetic resonance imaging studies in autism spectrum disorders.Brain imaging and behavior · 2023Pooled it
- Ethnicity, minority status, and inter-group bias: A systematic meta-analysis on fMRI studies.Frontiers in human neuroscience · 2022Pooled it
- Transcranial Direct Current Stimulation of the Temporoparietal Junction in Autism Spectrum Disorder: Results of a Phase-IIa Randomized, Double-Blind, Sham-Controlled Feasibility Study.Autism research : official journal of the International Society for Autism Research · 2025Trial
- Case Report: Sustained Cognitive Improvement and Reversible Brain Hypoperfusion in the Context of Posterior Fossa Arachnoid Cyst Shunting Procedure in KBG Syndrome.Cerebellum (London, England) · 2026Article
- Alteration of individual morphological brain networks in preschool children with autism spectrum disorder.Brain imaging and behavior · 2026Article
- Integrating Multimodal Neuroimaging and Physical-Health Markers for Autism Spectrum Disorder in the ABCD Study.Journal of integrative neuroscience · 2026Article
- Offenders with Autism Spectrum Disorder: A Clinical Case Series and Diagnostic Considerations in Forensic Psychiatry.Psychology research and behavior management · 2026Article
- Autistic traits and proneness to shame and guilt: The mediating role of functional connectivity of cortical midline structures.Personality neuroscience · 2026Article
- Enhancing MRI accessibility through community engagement for autistic young adults.Discover psychology · 2026Article
- Specific Association Patterns Between Brain Glutathione Levels, Myelination, and Functional Connectivity in Adults With Autism Spectrum Disorder.Autism research : official journal of the International Society for Autism Research · 2025Article
- Ultra-high resolution imaging of laminar thickness in face-selective cortex in autism.Cognitive, affective & behavioral neuroscience · 2025Article
- Multimodal Morphometric Similarity Network Analysis of Autism Spectrum Disorder.Brain sciences · 2025Article
- Links between brain structure and function in children with autism spectrum disorder by parallel independent component analysis.Brain imaging and behavior · 2025Article
- Alterations of triple network dynamic connectivity and repetitive behaviors after mini-basketball training program in children with autism spectrum disorder.Scientific reports · 2025Article
39 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Social impairments in autism spectrum disorder (ASD), a hallmark feature of its diagnosis, may underlie specific neural signatures that can aid in differentiating between those with and without ASD. To assess common and consistent patterns of differences in brain responses underlying social cognition in ASD, this study applied an activation likelihood estimation (ALE) meta-analysis to results from 50 neuroimaging studies of social cognition in children and adults with ASD. In addition, the group ALE clusters of activation obtained from this was used as a social brain mask to perform surface-based cortical morphometry (SBM) in an empirical structural MRI dataset collected from 55 ASD and 60 typically developing (TD) control participants. Overall, the ALE meta-analysis revealed consistent differences in activation in the posterior superior temporal sulcus at the temporoparietal junction, middle frontal gyrus, fusiform face area (FFA), inferior frontal gyrus (IFG), amygdala, insula, and cingulate cortex between ASD and TD individuals. SBM analysis showed alterations in the thickness, volume, and surface area in individuals with ASD in STS, insula, and FFA. Increased cortical thickness was found in individuals with ASD, the IFG. The results of this study provide functional and anatomical bases of social cognition abnormalities in ASD by identifying common signatures from a large pool of neuroimaging studies. These findings provide new insights into the quest for a neuroimaging-based marker for ASD. Hum Brain Mapp 37:3957-3978, 2016. © 2016 Wiley Periodicals, Inc.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.