Evidence map›Paper›PMID 27329335›Full record

ArticleNeuroscience2016

GABAergic mechanisms contributing to categorical amygdala responses to chemosensory signals.

Jenne M Westberry, Michael Meredith

Open access · greenAbstract read
In one paragraph

Article in Neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Amygdala Intercalated Cells: Gate Keepers and Conveyors of Internal State to the Circuits of Emotion.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Review
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Jenne M WestberryProgram in Neuroscience and Department Biological Science, Florida State University, Tallahassee, FL 32306-4295, USA. Electronic address: west6427@stthomas.edu.
Michael MeredithProgram in Neuroscience and Department Biological Science, Florida State University, Tallahassee, FL 32306-4295, USA. Electronic address: mmered@neuro.fsu.edu.
Florida State University · US

Funding

Chemosensory Training Program (CTP)T32DC000044 · NIDCD · FLORIDA STATE UNIVERSITY · PI DEBRA Ann FADOOL · 1995 to 2026
$5.3M
Chemosensory Processing in Chemical CommunicationR01DC005813 · NIDCD · FLORIDA STATE UNIVERSITY · PI MEREDITH, MICHAEL · 2003 to 2010
$1.7M
Central Processing of Chemosensory SignalsF31DC005725 · NIDCD · FLORIDA STATE UNIVERSITY · PI WESTBERRY, JENNE MITCHELL · 2002 to 2002
$26k
NIDCD NIH HHS F31 DC005725NIDCD NIH HHS R01 DC005813NIDCD NIH HHS T32 DC000044
6 · The paper itself

Abstract

Chemosensory stimuli from conspecific and heterospecific animals, elicit categorically different immediate-early gene response-patterns in medial amygdala in male hamsters and mice. We previously showed that conspecific signals activate posterior (MeP) as well as anterior medial amygdala (MeA), and especially relevant heterospecific signals such as chemosensory stimuli from potential predators also activate MeP in mice. Other heterospecific chemosignals activate MeA, but not MeP. Here we show that male hamster amygdala responds significantly differentially to different conspecific signals, by activating different proportions of cells of different phenotype, possibly leading to differential activation of downstream circuits. Heterospecific signals that fail to activate MeP do activate GABA-immunoreactive cells in the adjacent caudal main intercalated nucleus (mICNc) and elicit selective suppression of MeP cells bearing GABA-Receptors, suggesting GABA inhibition in MeP by GABAergic cells in mICNc. Overall, work presented here suggests that medial amygdala may discriminate between important conspecific social signals, distinguish them from the social signals of other species and convey that information to brain circuits eliciting appropriate social behavior.

Indexed as

Social PerceptionAmygdalaAnimalsCell CountDiscrimination, PsychologicalGABAergic Neuronsgamma-Aminobutyric AcidImmunohistochemistryMaleMesocricetusOdorantsOlfactory PerceptionPattern Recognition, PhysiologicalPhysical StimulationReceptors, GABASpecies Specificitygamma-Aminobutyric AcidReceptors, GABAchemosignalcircuitGABAmedial amygdalaolfactoryvomeronasal

Identifiers

PMID27329335
PMCPMC4955787
OpenAlexW2429975388

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.