Evidence map›Paper›PMID 27328960›Full record

ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2016

High relative density of lymphatic vessels predicts poor survival in tongue squamous cell carcinoma.

Miia Seppälä, Konsta Pohjola, Jussi Laranne, Markus Rautiainen, Heini Huhtala, Risto Renkonen, Karl Lemström, Timo Paavonen, Sanna Toppila-Salmi

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 3 pooled it
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 3 syntheses or guidelines pooled it, 14 citations in OpenAlex.

  1. The prognostic value of lymphatic vessel density in squamous cell carcinoma of the tongue: a systematic review and meta-analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Lymphatic Vessel Density or Area Are Not Reliable Prognostic Factors in Oral Cancer.Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology · 2026
    Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Miia SeppäläHaartman Institute, University of Helsinki, Haartmaninkatu 3, PO Box 21, 00014, Helsinki, Finland. miia.seppala@helsinki.fi.
Konsta PohjolaDepartment of Pathology, University of Tampere, Biokatu 10, 33520, Tampere, Finland.
Jussi LaranneDepartment of Otorhinolaryngology, Head and Neck Surgery, Tampere University Hospital, Teiskontie 35, PO Box 2000, 33521, Tampere, Finland.
Markus RautiainenDepartment of Otorhinolaryngology, Head and Neck Surgery, Tampere University Hospital, Teiskontie 35, PO Box 2000, 33521, Tampere, Finland.
Heini HuhtalaSchool of Health Sciences, University of Tampere, Medisiinarinkatu 3, 33520, Tampere, Finland.
Risto RenkonenTransplantation Laboratory, Haartman Institute, University of Helsinki, Haartmaninkatu 3, PO Box 21, 00014, Helsinki, Finland.
Karl LemströmTransplantation Laboratory, Haartman Institute, University of Helsinki, Haartmaninkatu 3, PO Box 21, 00014, Helsinki, Finland.
Timo PaavonenDepartment of Pathology, University of Tampere, Biokatu 10, 33520, Tampere, Finland.
Sanna Toppila-SalmiTransplantation Laboratory, Haartman Institute, University of Helsinki, Haartmaninkatu 3, PO Box 21, 00014, Helsinki, Finland.
Tampere University · FIUniversity of Helsinki · FIHelsinki University Hospital · FITampere University Hospital · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tongue cancer has a poor prognosis due to its early metastasis via lymphatic vessels. The present study aimed at evaluating lymphatic vessel density, relative density of lymphatic vessel, and diameter of lymphatic vessels and its predictive role in tongue cancer. Paraffin-embedded tongue and lymph node specimens (n = 113) were stained immunohistochemically with a polyclonal antibody von Willebrand factor, recognizing blood and lymphatic endothelium and with a monoclonal antibody podoplanin, recognizing lymphatic endothelium. The relative density of lymphatic vessels was counted by dividing the mean number of lymphatic vessels per microscopic field (podoplanin) by the mean number of all vessels (vWf) per microscopic field. The high relative density of lymphatic vessels (≥80 %) was associated with poor prognosis in tongue cancer. The relative density of lymphatic vessels predicted poor prognosis in the group of primary tumor size T1-T2 and in the group of non-metastatic cancer. The lymphatic vessel density and diameter of lymphatic vessels were not associated with tongue cancer survival. The relative density of lymphatic vessels might have clinically relevant prognostic impact. Further studies with increased number of patients are needed.

Indexed as

AdolescentAdultAgedAged, 80 and overAntibodies, MonoclonalBlood VesselsCarcinoma, Squamous CellFemaleHumansHyperplasiaLymphatic MetastasisLymphatic VesselsMaleMembrane GlycoproteinsMiddle AgedPodoplaninAntibodies, MonoclonalMembrane GlycoproteinsPDPN protein, humanPodoplaninVon Willebrand antigenvon Willebrand FactorHead and neck cancerImmunohistochemistryLymphatic vesselsSurvivalTongue cancer

Identifiers

PMID27328960
OpenAlexW2469202702

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.