ArticleScientific reports2016
Microfluidic neurite guidance to study structure-function relationships in topologically-complex population-based neural networks.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Functional discrimination of CSF from Alzheimer's patients in a brain on chip platform.Scientific reports · 2025Article
- Electrophysiological features of cortical 3D networks are deeply modulated by scaffold properties.APL bioengineering · 2024Article
- Connectivity and network burst properties of in-vitro neuronal networks induced by a clustered structure with alginate hydrogel patterning.Biomedical engineering letters · 2023Article
- Proof-of-Concept Human Organ-on-Chip Study: First Step of Platform to Assess Neuro-Immunological Communication Involved in Inflammatory Bowel Diseases.International journal of molecular sciences · 2023Article
- Human Brain Organoids-on-Chip: Advances, Challenges, and Perspectives for Preclinical Applications.Pharmaceutics · 2022Review
- Microfluidics for Neuronal Cell and Circuit Engineering.Chemical reviews · 2022Review
- Neurons-on-a-Chip:Molecules and cells · 2022Review
- Deposition chamber technology as building blocks for a standardized brain-on-chip framework.Microsystems & nanoengineering · 2022Article
- Interaction of micropatterned topographical and biochemical cues to direct neurite growth from spiral ganglion neurons.Hearing research · 2021Article
- Hydrogels as artificial matrices for cell seeding in microfluidic devices.RSC advances · 2020Review
- Microphysiological Systems for Neurodegenerative Diseases in Central Nervous System.Micromachines · 2020Review
- Micropatterned nanolayers immobilized with nerve growth factor for neurite formation of PC12 cells.International journal of nanomedicine · 2019Article
- The Need for Physiological Micro-Nanofluidic Systems of the Brain.Frontiers in bioengineering and biotechnology · 2019Review
- Simple and Inexpensive Paper-Based Astrocyte Co-culture to Improve Survival of Low-Density Neuronal Networks.Frontiers in neuroscience · 2018Article
- A Microfluidic Platform for the Characterisation of CNS Active Compounds.Scientific reports · 2017Article
- Design of Cultured Neuron Networks in vitro with Predefined Connectivity Using Asymmetric Microfluidic Channels.Scientific reports · 2017Article
- Neural Circuits on a Chip.Micromachines · 2016Review
Corrections and comments
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Authors and funding
5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The central nervous system is a dense, layered, 3D interconnected network of populations of neurons, and thus recapitulating that complexity for in vitro CNS models requires methods that can create defined topologically-complex neuronal networks. Several three-dimensional patterning approaches have been developed but none have demonstrated the ability to control the connections between populations of neurons. Here we report a method using AC electrokinetic forces that can guide, accelerate, slow down and push up neurites in un-modified collagen scaffolds. We present a means to create in vitro neural networks of arbitrary complexity by using such forces to create 3D intersections of primary neuronal populations that are plated in a 2D plane. We report for the first time in vitro basic brain motifs that have been previously observed in vivo and show that their functional network is highly decorrelated to their structure. This platform can provide building blocks to reproduce in vitro the complexity of neural circuits and provide a minimalistic environment to study the structure-function relationship of the brain circuitry.
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