ArticleJournal of neuroscience methods2016
Automated segmentation and enhancement of optical coherence tomography-acquired images of rodent brain.
Article in Journal of neuroscience methods, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- Endothelial expression of human soluble epoxide hydrolase worsens acute microvascular and tissue injury after stroke in female mice with early-stage diabetes mellitus.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026Article
- Optical coherence tomography (OCT) and OCT angiography: Technological development and applications in brain science.Theranostics · 2025Review
- GPR39 Knockout Worsens Microcirculatory Response to Experimental Stroke in a Sex-Dependent Manner.Translational stroke research · 2023Article
- Non-Invasive Monitoring of Cutaneous Wound Healing in Non-Diabetic and Diabetic Model of Adult Zebrafish Using OCT Angiography.Bioengineering (Basel, Switzerland) · 2023Article
- Sex Difference in Capillary Reperfusion After Transient Middle Cerebral Artery Occlusion in Diabetic Mice.Stroke · 2023Article
- Enhance Safety in Aneurysm Surgery: Strategies for Prevention of Intraoperative Vascular Complications.Acta neurochirurgica. Supplement · 2023Article
- Article
- Role of endothelium-pericyte signaling in capillary blood flow response to neuronal activity.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Article
- Automatic skin lesion area determination of basal cell carcinoma using optical coherence tomography angiography and a skeletonization approach: Preliminary results.Journal of biophotonics · 2019Article
- Review of methods and applications of attenuation coefficient measurements with optical coherence tomography.Journal of biomedical optics · 2019Review
- Pericyte constriction underlies capillary derecruitment during hyperemia in the setting of arterial stenosis.American journal of physiology. Heart and circulatory physiology · 2019Article
- LongitudinalJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019Article
- Optimized depth-resolved estimation to measure optical attenuation coefficients from optical coherence tomography and its application in cerebral damage determination.Journal of biomedical optics · 2019Article
- Attenuation correction assisted automatic segmentation for assessing choroidal thickness and vasculature with swept-source OCT.Biomedical optics express · 2018Article
- Optical coherence tomography angiography of normal skin and inflammatory dermatologic conditions.Lasers in surgery and medicine · 2018Article
- Tail artifact removal in OCT angiography images of rodent cortex.Journal of biophotonics · 2017Article
- Repeatability of vessel density measurement in human skin by OCT-based microangiography.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2017Article
- Whole-body positional manipulators for ocular imaging of anaesthetised mice and rats: a do-it-yourself guide.BMJ open ophthalmology · 2017Article
- Cerebral capillary velocimetry based on temporal OCT speckle contrast.Biomedical optics express · 2016Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundOptical coherence tomography (OCT) is a non-invasive optical imaging method that has proven useful in various fields such as ophthalmology, dermatology and neuroscience. In ophthalmology, significant progress has been made in retinal layer segmentation and enhancement of OCT images. There are also segmentation algorithms to separate epidermal and dermal layers in OCT-acquired images of human skin. NEW
methodWe describe simple image processing methods that allow automatic segmentation and enhancement of OCT images of rodent brain.
resultsWe demonstrate the effectiveness of the proposed methods for OCT-based microangiography (OMAG) and tissue injury mapping (TIM) of mouse cerebral cortex. The results show significant improvement in image contrast, delineation of tissue injury, allowing visualization of different layers of capillary beds. COMPARISON WITH EXISTING
methodsPreviously reported methods for other applications are yet to be used in neuroscience due to the complexity of tissue anatomy, unique physiology and technical challenges.
conclusionsOCT is a promising tool that provides high resolution in vivo microvascular and structural images of rodent brain. By automatically segmenting and enhancing OCT images, structural and microvascular changes in mouse cerebral cortex after stroke can be monitored in vivo with high contrast.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.