Evidence map›Paper›PMID 27328309›Full record

ReviewNanoscale2016

Photonanomedicine: a convergence of photodynamic therapy and nanotechnology.

Girgis Obaid, Mans Broekgaarden, Anne-Laure Bulin, Huang-Chiao Huang, Jerrin Kuriakose, Joyce Liu, Tayyaba Hasan

Abstract readReview
In one paragraph

Review in Nanoscale, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed.

  1. Review
  2. Article
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  8. Review
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  10. Review
  11. Review
  12. Review
  13. Article
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  15. A Perfusion Model to Evaluate Response to Photodynamic Therapy in 3D Tumors.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
  16. Review
  17. Review
  18. Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Girgis ObaidWellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA.
Mans Broekgaarden
Anne-Laure Bulin
Huang-Chiao Huang
Jerrin Kuriakose
Joyce Liu
Tayyaba Hasan

Funding

Small Molecule Enhancers of Photodynamic Therapy for Skin CancerP01CA084203 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI Tayyaba Hasan · 2001 to 2026
$27.9M
Targeted Photoactivable Nanocells: Image-based Drug Delivery and Dosimetry in GBMR01CA156177 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI HASAN, TAYYABA, POGUE, BRIAN WILLIAM · 2011 to 2015
$2.5M
Ovarian Cancer PDT: Multi-intracellular targeting and Image-guided dosimetryR01CA160998 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI HASAN, TAYYABA · 2011 to 2015
$2.0M
Multifunctional, GBM-Activatable Nanocarriers For Image-Guided PhotochemotherapyR00CA194269 · NCI · UNIV OF MARYLAND, COLLEGE PARK · PI HUANG, HUANG CHIAO · 2018 to 2020
$701k
Multifunctional, GBM-activatable nanocarriers for image-guided photochemotherapyK99CA194269 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI HUANG, HUANG CHIAO · 2016 to 2017
$358k
NCI NIH HHS K99 CA194269NCI NIH HHS P01 CA084203NCI NIH HHS R00 CA194269NCI NIH HHS R01 CA156177NCI NIH HHS R01 CA160998
6 · The paper itself

Abstract

As clinical nanomedicine has emerged over the past two decades, phototherapeutic advancements using nanotechnology have also evolved and impacted disease management. Because of unique features attributable to the light activation process of molecules, photonanomedicine (PNM) holds significant promise as a personalized, image-guided therapeutic approach for cancer and non-cancer pathologies. The convergence of advanced photochemical therapies such as photodynamic therapy (PDT) and imaging modalities with sophisticated nanotechnologies is enabling the ongoing evolution of fundamental PNM formulations, such as Visudyne®, into progressive forward-looking platforms that integrate theranostics (therapeutics and diagnostics), molecular selectivity, the spatiotemporally controlled release of synergistic therapeutics, along with regulated, sustained drug dosing. Considering that the envisioned goal of these integrated platforms is proving to be realistic, this review will discuss how PNM has evolved over the years as a preclinical and clinical amalgamation of nanotechnology with PDT. The encouraging investigations that emphasize the potent synergy between photochemistry and nanotherapeutics, in addition to the growing realization of the value of these multi-faceted theranostic nanoplatforms, will assist in driving PNM formulations into mainstream oncological clinical practice as a necessary tool in the medical armamentarium.

Indexed as

NanomedicinePhotochemotherapyNeoplasmsPhotochemistryTheranostic Nanomedicine

Identifiers

PMID27328309
PMCPMC4956486

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.