Evidence map›Paper›PMID 27328058›Full record

ReviewBrain pathology (Zurich, Switzerland)2016

Physical Exercise and Brain Mitochondrial Fitness: The Possible Role Against Alzheimer's Disease.

T C Bernardo, I Marques-Aleixo, J Beleza, P J Oliveira, A Ascensão, J Magalhães

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Brain pathology (Zurich, Switzerland), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  6. Nutrition and longevity - diet in centenarians.Journal of translational medicine · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

T C BernardoCIAFEL-Research Centre in Physical Activity, , Health and Leisure, Faculty of Sport, University of Porto, Porto, Portugal. telmasbernardo@gmail.com.
I Marques-AleixoCIAFEL-Research Centre in Physical Activity, , Health and Leisure, Faculty of Sport, University of Porto, Porto, Portugal.
J BelezaCIAFEL-Research Centre in Physical Activity, , Health and Leisure, Faculty of Sport, University of Porto, Porto, Portugal.
P J OliveiraCNC-Centre for Neuroscience and Cell Biology, UC-Biotech, Biocant Park, University of Coimbra, Coimbra, Portugal.
A AscensãoCIAFEL-Research Centre in Physical Activity, , Health and Leisure, Faculty of Sport, University of Porto, Porto, Portugal.
J MagalhãesCIAFEL-Research Centre in Physical Activity, , Health and Leisure, Faculty of Sport, University of Porto, Porto, Portugal.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exercise is one of the most effective strategies to maintain a healthy body and mind, with particular beneficial effects of exercise on promoting brain plasticity, increasing cognition and reducing the risk of cognitive decline and dementia in later life. Moreover, the beneficial effects resulting from increased physical activity occur at different levels of cellular organization, mitochondria being preferential target organelles. The relevance of this review article relies on the need to integrate the current knowledge of proposed mechanisms, focus mitochondria, to explain the protective effects of exercise that might underlie neuroplasticity and seeks to synthesize these data in the context of exploring exercise as a feasible intervention to delay cognitive impairment associated with neurodegenerative conditions, particularly Alzheimer disease.

Indexed as

Alzheimer DiseaseAnimalsBrainExerciseExercise TherapyHumansMitochondriaMitochondrial Diseasestau Proteinstau ProteinsAlzheimer's diseaseexercisemitochondria

Identifiers

PMID27328058
PMCPMC8029062

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.