Evidence map›Paper›PMID 27328008›Full record

ArticleNature immunology2016

Innate lymphoid cell function in the context of adaptive immunity.

Jennifer K Bando, Marco Colonna

Abstract read
In one paragraph

Article in Nature immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed.

  1. Innate Immune Protection Against HIV in the Female Genital Tract.American journal of reproductive immunology (New York, N.Y. : 1989) · 2026
    Review
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  12. Humanized mouse models for immuno-oncology research.Nature reviews. Clinical oncology · 2023
    Review
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  14. Article
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  16. Article
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  19. Article
  20. Article

6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jennifer K BandoDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.
Marco ColonnaDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.

Funding

Mucosal Immune Defense Mechanisms of the Urinary BladderU01AI095542 · NIAID · WASHINGTON UNIVERSITY · PI COLONNA, MARCO, HULTGREN, SCOTT J. · 2011 to 2020
$9.8M
THE ROLE OF NK-22 CELLS IN ANTI-HIV-1 MUCOSAL IMMUNITYR01DE021255 · NIDCR · WASHINGTON UNIVERSITY · PI COLONNA, MARCO · 2010 to 2014
$1.9M
CRTAM-CADM1 INTERACTION IN THE BIOLOGY OF GUT LYMPHOCYTESR01DK103039 · NIDDK · WASHINGTON UNIVERSITY · PI COLONNA, MARCO · 2015 to 2018
$1.4M
NIAID NIH HHS U01 AI095542NIDCR NIH HHS R01 DE021255NIDDK NIH HHS R01 DK103039
6 · The paper itself

Abstract

Innate lymphoid cells (ILCs) are a family of innate immune cells that have diverse functions during homeostasis and disease. Subsets of ILCs have phenotypes that mirror those of polarized helper T cell subsets in their expression of core transcription factors and effector cytokines. Given the similarities between these two classes of lymphocytes, it is important to understand which functions of ILCs are specialized and which are redundant with those of T cells. Here we discuss genetic mouse models that have been used to delineate the contributions of ILCs versus those of T cells and review the current understanding of the specialized in vivo functions of ILCs.

Indexed as

Immunity, InnateAnimalsAnimals, Genetically ModifiedCytokinesDisease Models, AnimalHomeostasisHumansInflammationLymphocytesMiceTh1 CellsTh2 CellsCytokines

Identifiers

PMID27328008
PMCPMC5156404

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.