Evidence map›Paper›PMID 27327842›Full record

ArticleSteroids2016

Further evidence for a membrane receptor that binds glucocorticoids in the rodent hypothalamus.

Jebun Nahar, Jennifer R Rainville, Gary P Dohanich, Jeffrey G Tasker

Open access · greenAbstract read
In one paragraph

Article in Steroids, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.9field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. Actions of Steroids: New Neurotransmitters.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016
    Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jebun NaharDepartment of Cell and Molecular Biology, Tulane University, New Orleans, LA 70118, United States.
Jennifer R RainvilleDepartment of Cell and Molecular Biology, Tulane University, New Orleans, LA 70118, United States.
Gary P DohanichDepartment of Psychology, Tulane University, New Orleans, LA 70118, United States; Neuroscience Program, Tulane University, New Orleans, LA 70118, United States.
Jeffrey G TaskerDepartment of Cell and Molecular Biology, Tulane University, New Orleans, LA 70118, United States; Neuroscience Program, Tulane University, New Orleans, LA 70118, United States. Electronic address: tasker@tulane.edu.
Tulane University · US

Funding

Acute Corticosteriod Actions in the HypothalamusR01MH066958 · NIMH · TULANE UNIVERSITY OF LOUISIANA · PI TASKER, JEFFREY G · 2003 to 2013
$3.3M
Cellular Plasticity and HPA Axis DysfunctionR01MH069879 · NIMH · TULANE UNIVERSITY OF LOUISIANA · PI TASKER, JEFFREY G · 2004 to 2009
$1.9M
NIMH NIH HHS R01 MH066958NIMH NIH HHS R01 MH069879
6 · The paper itself

Abstract

In parallel with their well-characterized delayed genomic effects, steroid hormones exhibit rapid, non-genomic effects at molecular, cellular and behavioral levels. We have proposed a model of rapid, non-genomic glucocorticoid inhibition of hypothalamic neuroendocrine cells through a putative membrane-associated glucocorticoid receptor (GR). Here we tested for plasma membrane GR immunoreactivity and binding in the hypothalamic supraoptic and paraventricular nuclei. Selective cross-linking of membrane proteins with membrane-impermeant BS

Indexed as

AnimalsBlotting, WesternCell MembraneCorticosteroneCytosolDexamethasoneGlucocorticoidsHypothalamusIn Vitro TechniquesMaleMiceProtein BindingRatsReceptors, GlucocorticoidCorticosteroneDexamethasoneGlucocorticoidsReceptors, GlucocorticoidCorticosteroidGlucocorticoid receptorHPAHypothalamusMembrane cross-linkingStress

Identifiers

PMID27327842
PMCPMC5053862
OpenAlexW2423587663

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.