ArticlePloS one2016
The Degradation Interface of Magnesium Based Alloys in Direct Contact with Human Primary Osteoblast Cells.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 62 citations in OpenAlex.
- Biomedical Applications of Gadolinium-Containing Biomaterials: Not Only MRI Contrast Agent.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Towards Correlative Raman Spectroscopy-STEM Investigations Performed on a Magnesium-Silver Alloy FIB Lamella.Nanomaterials (Basel, Switzerland) · 2025Article
- Towards Accurate Biocompatibility: Rethinking Cytotoxicity Evaluation for Biodegradable Magnesium Alloys in Biomedical Applications.Journal of functional biomaterials · 2024Article
- Gene regulatory network analysis identifies MYL1, MDH2, GLS, and TRIM28 as the principal proteins in the response of mesenchymal stem cells to MgComputational and structural biotechnology journal · 2024Article
- Article
- Multiscale morphological analysis of bone microarchitecture around Mg-10Gd implants.Bioactive materials · 2023Article
- Advances in Bioresorbable Triboelectric Nanogenerators.Chemical reviews · 2023Review
- Article
- High-resolutionBioactive materials · 2022Article
- Influence of Surface Roughness on Biodegradability and Cytocompatibility of High-Purity Magnesium.Materials (Basel, Switzerland) · 2022Article
- Compositional Tailoring of Mg-2Zn-1Ca Alloy Using Manganese to Enhance Compression Response and In-Vitro Degradation.Materials (Basel, Switzerland) · 2022Article
- Influences of Extrusion and Silver Content on the Degradation of Mg-Ag AlloysBioinorganic chemistry and applications · 2022Article
- An ex vivo physiologic and hyperplastic vessel culture model to study intra-arterial stent therapies.Biomaterials · 2021Article
- Mg Biodegradation Mechanism Deduced from the Local Surface Environment under Simulated Physiological Conditions.Advanced healthcare materials · 2021Article
- Optimizing an Osteosarcoma-Fibroblast Coculture Model to Study Antitumoral Activity of Magnesium-Based Biomaterials.International journal of molecular sciences · 2020Article
- Comparative Study of the Structure, Properties, and Corrosion Behavior of Sr-Containing Biocoatings on Mg0.8Ca.Materials (Basel, Switzerland) · 2020Article
- Investigation of a cyanine dye assay for the evaluation of the biocompatibility of magnesium alloys by direct and indirect methods.Bioactive materials · 2020Article
- Alloying and Processing Effects on the Microstructure, Mechanical Properties, and Degradation Behavior of Extruded Magnesium Alloys Containing Calcium, Cerium, or Silver.Materials (Basel, Switzerland) · 2020Article
- Proteome analysis of human mesenchymal stem cells undergoing chondrogenesis when exposed to the products of various magnesium-based materials degradation.Bioactive materials · 2019Article
- Magnesium degradation under physiological conditions - Best practice.Bioactive materials · 2018Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Magnesium alloys have been identified as a new generation material of orthopaedic implants. In vitro setups mimicking physiological conditions are promising for material / degradation analysis prior to in vivo studies however the direct influence of cell on the degradation mechanism has never been investigated. For the first time, the direct, active, influence of human primary osteoblasts on magnesium-based materials (pure magnesium, Mg-2Ag and Mg-10Gd alloys) is studied for up to 14 days. Several parameters such as composition of the degradation interface (directly beneath the cells) are analysed with a scanning electron microscope equipped with energy dispersive X-ray and focused ion beam. Furthermore, influence of the materials on cell metabolism is examined via different parameters like active mineralisation process. The results are highlighting the influences of the selected alloying element on the initial cells metabolic activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.