ArticleMechanisms of ageing and development2016
Differential effects of leucine supplementation in young and aged mice at the onset of skeletal muscle regeneration.
Article in Mechanisms of ageing and development, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 23 citations in OpenAlex.
- Whey Protein Isolate-Encapsulated Astaxanthin Nanoemulsion More Effectively Mitigates Skeletal Muscle Atrophy in Dexamethasone-Induced Mice.Nutrients · 2025Article
- Leucine Supplementation Exacerbates Morbidity in Male but Not Female Mice with Colorectal Cancer-Induced Cachexia.Nutrients · 2023Article
- Effects of PGC-1α overexpression on the myogenic response during skeletal muscle regeneration.Sports medicine and health science · 2022Article
- The effect of autologous repair and voluntary wheel running on force recovery in a rat model of volumetric muscle loss.Experimental physiology · 2021Article
- Regulation of mitochondrial quality following repeated bouts of hindlimb unloading.Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme · 2020Article
- Evaluation of Hypoglycemic Therapy Through Physical Exercise in n5STZ-Induced Diabetes Rats.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
- Late life maintenance and enhancement of functional exercise capacity in low and high responding rats after low intensity treadmill training.Experimental gerontology · 2019Article
- Roles of mTOR Signaling in Tissue Regeneration.Cells · 2019Review
- Effect of 8-week leucine supplementation and resistance exercise training on muscle hypertrophy and satellite cell activation in rats.Physiological reports · 2018Article
- Mitochondrial degeneration precedes the development of muscle atrophy in progression of cancer cachexia in tumour-bearing mice.Journal of cachexia, sarcopenia and muscle · 2017Article
- The Akt/mTOR pathway: Data comparing young and aged mice with leucine supplementation at the onset of skeletal muscle regeneration.Data in brief · 2016Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Aging decreases the ability of skeletal muscle to respond to injury. Leucine has been demonstrated to target protein synthetic pathways in skeletal muscle thereby enhancing this response. However, the effect of aging on leucine-induced alterations in protein synthesis at the onset of skeletal muscle regeneration has not been fully elucidated. The purpose of this study was to determine if aging alters skeletal muscle regeneration and leucine-induced alterations in markers of protein synthesis. The tibialis anterior of young (3 months) and aged (24 months) female C57BL/6J mice were injected with either bupivacaine or PBS, and the mice were given ad libitum access to leucine-supplemented or normal drinking water. Protein and gene expression of markers of protein synthesis and degradation, respectively, were analyzed at three days post-injection. Following injury in young mice, leucine supplementation was observed to elevate only p-p70S6K. In aged mice, leucine was shown to elicit higher p-mTOR content with and without injury, and p-4EBP-1 content post-injury. Additionally in aged mice, leucine was shown to elicit higher content of relative p70S6K post-injury. Our study shows that leucine supplementation affects markers of protein synthesis at the onset of skeletal muscle regeneration differentially in young and aged mice.
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