ReviewWiley interdisciplinary reviews. Systems biology and medicine2016
The reverse control of irreversible biological processes.
Review in Wiley interdisciplinary reviews. Systems biology and medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed.
- Reverse control of biological networks to restore phenotype landscapes.Science advances · 2025Article
- miRNAs from Zebrafish Embryo Extracts Inhibit Breast Cancer Invasiveness and Migration by Modulating miR-218-5p/PI3K Pathway.International journal of molecular sciences · 2025Article
- Control of Cellular Differentiation Trajectories for Cancer Reversion.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Critical transition and reversion of tumorigenesis.Experimental & molecular medicine · 2023Review
- NETISCE: a network-based tool for cell fate reprogramming.NPJ systems biology and applications · 2022Article
- Diabetes mellitus can cause cardiomyopathy disorders by inducing the aging pathway.Iranian journal of basic medical sciences · 2021Article
- Of mitogens and morphogens: modelling Sonic Hedgehog mechanisms in vertebrate development.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- Boolean Feedforward Neural Network Modeling of Molecular Regulatory Networks for Cellular State Conversion.Frontiers in physiology · 2020Article
- Reconciling periodic rhythms of large-scale biological networks by optimal control.Royal Society open science · 2020Article
- Signal flow control of complex signaling networks.Scientific reports · 2019Article
- Next Generation Networks: Featuring the Potential Role of Emerging Applications in Translational Oncology.Journal of clinical medicine · 2019Article
- The phenotype control kernel of a biomolecular regulatory network.BMC systems biology · 2018Article
- ATLANTIS - Attractor Landscape Analysis Toolbox for Cell Fate Discovery and Reprogramming.Scientific reports · 2018Article
- Quantitative evaluation and reversion analysis of the attractor landscapes of an intracellular regulatory network for colorectal cancer.BMC systems biology · 2017Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most biological processes have been considered to be irreversible for a long time, but some recent studies have shown the possibility of their reversion at a cellular level. How can we then understand the reversion of such biological processes? We introduce a unified conceptual framework based on the attractor landscape, a molecular phase portrait describing the dynamics of a molecular regulatory network, and the phenotype landscape, a map of phenotypes determined by the steady states of particular output molecules in the attractor landscape. In this framework, irreversible processes involve reshaping of the phenotype landscape, and the landscape reshaping causes the irreversibility of processes. We suggest reverse control by network rewiring which changes network dynamics with constant perturbation, resulting in the restoration of the original phenotype landscape. The proposed framework provides a conceptual basis for the reverse control of irreversible biological processes through network rewiring. WIREs Syst Biol Med 2016, 8:366-377. doi: 10.1002/wsbm.1346 For further resources related to this article, please visit the WIREs website.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.