Evidence map›Paper›PMID 27327079›Full record

ReviewTranscription2016

Specialization versus conservation: How Pol I and Pol III use the conserved architecture of the pre-initiation complex for specialized transcription.

Niklas A Hoffmann, Yashar Sadian, Lucas Tafur, Jan Kosinski, Christoph W Müller

Abstract readReview
In one paragraph

Review in Transcription, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Niklas A Hoffmanna European Molecular Biology Laboratory (EMBL) , Structural and Computational Biology Unit , Heidelberg , Germany.
Yashar Sadiana European Molecular Biology Laboratory (EMBL) , Structural and Computational Biology Unit , Heidelberg , Germany.
Lucas Tafura European Molecular Biology Laboratory (EMBL) , Structural and Computational Biology Unit , Heidelberg , Germany.
Jan Kosinskia European Molecular Biology Laboratory (EMBL) , Structural and Computational Biology Unit , Heidelberg , Germany.
Christoph W Müllera European Molecular Biology Laboratory (EMBL) , Structural and Computational Biology Unit , Heidelberg , Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Here, we discuss the overall architecture of the RNA polymerase I (Pol I) and III (Pol III) core enzymes and their associated general transcription factors in the context of models of the Pol I and Pol III pre-initiation complexes, thereby highlighting potential functional adaptations of the Pol I and Pol III enzymes to their respective transcription tasks. Several new insights demonstrate the great degree of specialization of each of the eukaryotic RNA polymerases that is only beginning to be revealed as the structural and functional characterization of all eukaryotic RNA polymerases and their pre-initiation complexes progresses.

Indexed as

Binding SitesConserved SequenceTranscription Initiation, GeneticMultiprotein ComplexesPromoter Regions, GeneticProtein BindingProtein Interaction Domains and MotifsRNA Polymerase IRNA Polymerase IIISubstrate SpecificityTranscription Factors, TFIITranscription Factor TFIIBMultiprotein ComplexesRNA Polymerase IRNA Polymerase IIITranscription Factors, TFIITranscription Factor TFIIBtranscription factor TFIIEtranscription factor TFIIFpre-initiation complexRNA polymerase IRNA polymerase IITFIIBTFIIETFIIFtranscription

Identifiers

PMID27327079
PMCPMC4984676

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.