ArticlePeerJ2016
Geriatric syndromes are potential determinants of the medication adherence status in prevalent dialysis patients.
Article in PeerJ, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Pooled it
- Frailty in Focus: A Scoping Review of Frailty Instruments from the Kidney Disease Aging Research Collaborative.Clinical journal of the American Society of Nephrology : CJASN · 2026Article
- Promoting Medication Adherence in the Elderly: Factors and Insights From a Cross-Sectional Study.Aging medicine (Milton (N.S.W)) · 2025Article
- Medication Use by Older Adults with Frailty: A Scoping Review.Pharmacy (Basel, Switzerland) · 2025Review
- The Influence of Frailty on Pharmacotherapy Adherence and Adverse Drug Reactions in Older Psychiatric Patients.Geriatrics (Basel, Switzerland) · 2025Article
- Narrative Review: Clinical Implications and Assessment of Frailty in Patients With Advanced CKD.Kidney international reports · 2024Review
- Use of frailty assessment instruments in nephrology populations: a scoping review.BMC geriatrics · 2023Article
- Development of a Predictive Nomogram for Estimating Medication Nonadherence in Hemodialysis Patients.Medical science monitor : international medical journal of experimental and clinical research · 2022Article
- Phosphate binders usage, patients knowledge, and adherence. A cross-sectional study in 4 centers at Qassim, Saudi Arabia.Saudi medical journal · 2020Article
- Covid-19 Pandemic: Maximizing Future Vaccination Treatments Considering Aging and Frailty.Frontiers in medicine · 2020Article
- How May Coexisting Frailty Influence Adherence to Treatment in Elderly Hypertensive Patients?International journal of hypertension · 2019Article
- Organizational Readiness to Implement the Chronic Disease Self-Management Program in Dialysis Facilities.Geriatrics (Basel, Switzerland) · 2018Article
- Adherence to pharmacological and non-pharmacological treatment of frail hypertensive patients.Journal of geriatric cardiology : JGC · 2018Article
- Psychometric evaluation of the Polish version of the Adherence to Refills and Medications Scale (ARMS) in adults with hypertension.Patient preference and adherence · 2018Article
- Phosphate-control adherence in hemodialysis patients: current perspectives.Patient preference and adherence · 2018Review
- Hypertension and Frailty Syndrome in Old Age: Current Perspectives.Cardiac failure review · 2017Article
- Effect of frailty syndrome on treatment compliance in older hypertensive patients.Clinical interventions in aging · 2017Article
- The influence of frailty syndrome on medication adherence among elderly patients with hypertension.Clinical interventions in aging · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background. Geriatric syndromes (GS) exhibit high prevalence in patients with end-stage renal disease (ESRD) under chronic dialysis irrespective of age. We sought to determine whether GS influences medication adherence in ESRD patients. Methods. A prospective cohort of chronic dialysis patients was assembled. The presence of GS components, including frailty/prefrailty, polypharmacy, and malnutrition, were ascertained through a validated questionnaire, electronic records and chart abstraction, and laboratory tests. The severity of medication non-adherence was defined using the eight-item Morisky Medication Adherence Scale (MMAS). Multiple logistic regression analysis was performed targeting MMAS results and incorporating relevant clinical features and GS. Results. The prevalence of frailty/pre-frailty, polypharmacy, and hypoalbuminemia/ malnutrition among the enrolled participants was 66.7%, 94%, and 14%, respectively. The average MMAS scores in these dialysis patients were 2 ± 1.7 (range, 0-6), with only 15.7% exhibiting high medication adherence. Multiple regression analyses showed that the absence of frailty/pre-frailty (P = 0.01) were significantly associated with poorer medication adherence, while the presence of polypharmacy (P = 0.02) and lower serum albumin, a potential sign of malnutrition (P = 0.03), were associated with poor adherence in another model. Conclusion. This study is among the very few reports addressing GS and medication adherence, especially in ESRD patients. Interventions targeting frailty, polypharmacy, and malnutrition might potentially improve the medication non-adherence and symptom control in these pill-burdened patients.
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Registered trials
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