ReviewWorld journal of gastrointestinal oncology2016
Genetic risks and familial associations of small bowel carcinoma.
Review in World journal of gastrointestinal oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 53 citations in OpenAlex.
- DNA Content and DNA Damage in Raw and Heat-Processed Foods.Journal of agricultural and food chemistry · 2025Article
- Predisposing conditions in patients with small intestinal adenocarcinomas in the Netherlands: A 20-year nationwide cohort study.International journal of cancer · 2025Article
- The Many Faces of Intestinal Tumors in Adults, Including the Primary Role of CT Imaging in Emergencies and the Important Role of Cross-Sectional Imaging: A Pictorial Review.Healthcare (Basel, Switzerland) · 2025Review
- BRCA2-Related Hereditary Cancer Syndrome-Associated Small Bowel Adenocarcinoma With Multiple BRCA2 Mutations: A Case Report and Review of the Literature.Cancer reports (Hoboken, N.J.) · 2025Review
- Image-enhanced endoscopy in upper gastrointestinal disease: focusing on texture and color enhancement imaging and red dichromatic imaging.Clinical endoscopy · 2025Review
- Mixed neuroendocrine and adenocarcinoma of gastrointestinal tract: A complex diagnosis and therapeutic challenge.World journal of gastrointestinal oncology · 2024Article
- Synchronous gastric and colon cancers: Important to consider hereditary syndromes and chronic inflammatory disease associations.World journal of gastrointestinal oncology · 2024Article
- Immune signature of small bowel adenocarcinoma and the role of tumor microenvironment.World journal of gastroenterology · 2024Article
- Clinical features and distribution of the APC variant in duodenal and ampullary polyps in patients with familial adenomatous polyposis: a multicenter retrospective cohort study in Japan.International journal of clinical oncology · 2024Article
- Hereditary polyposis syndromes remain a challenging disease entity: Old dilemmas and new insights.World journal of gastrointestinal surgery · 2023Review
- Risk factors for small intestinal adenocarcinomas that are common in the proximal small intestine.World journal of gastroenterology · 2022Review
- Small Bowel Adenocarcinoma: 10-Year Experience in a Cancer Center-The Ottawa Hospital (TOH).Current oncology (Toronto, Ont.) · 2022Article
- Review
- Review
- Identification of Lynch Syndrome Carriers among Patients with Small Bowel Adenocarcinoma.Cancers · 2021Article
- Adenocarcinoma of the fourth portion of duodenum presenting as intussusception: an unusual manifestation of rare pathology.BMJ case reports · 2021Article
- Chemopreventive Effect of Dietary Anthocyanins against Gastrointestinal Cancers: A Review of Recent Advances and Perspectives.International journal of molecular sciences · 2020Review
- Article
- A case of small bowel adenocarcinoma wherein nivolumab conferred temporary benefit in disease control.Clinical journal of gastroenterology · 2020Article
- New Insights Into the Indications for Intestinal Transplantation: Consensus in the Year 2019.Transplantation · 2020Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adenocarcinoma of small intestines (SBA) is a relatively rare malignancy with poor outcomes due to delayed diagnosis. Fifty percent of patients have metastases on presentation and therefore early detection and treatment offers the best long term outcomes. Certain genetic polyposis syndromes and familial diseases are associated with increased risks for SBA. These include familial adenomatous polyposis (FAP), Lynch syndromes (LS), Juvenile polyposis syndrome, Peutz-Jeghers syndrome, Crohn's disease (CD) and celiac disease. Mutations in APC gene, Mismatch repair genes, STK11 gene, and SMAD4 gene have been implicated for the genetic diseases respectively. While there are no specific inherited genetic mutations for CD, genome-wide association studies have established over 140 loci associated with CD. CpG island mutations with defects in mismatch repair genes have been identified in celiac disease. Significant diagnostic advances have occurred in the past decade and intuitively, it would seem beneficial to use these advanced modalities for surveillance of these patients. At present it is debatable and no clear data exists to support this approach except for established guidelines to diagnose duodenal polyps in FAP, and LS. Here we discuss the genetic alterations, cancer risks, signaling mechanisms and briefly touch the surveillance modalities available for these genetic and clinical syndromes. English language articles from PubMed/Medline and Embase was searched were collected using the phrases "small-bowel adenocarcinoma, genetics, surveillance, familial adenomatous polyposis, lynch syndromes, Peutz-Jeghers syndrome, juvenile polyposis syndrome, CD and celiac disease". Figures, tables and schematic diagram to illustrate pathways are included in the review.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.