Evidence map›Paper›PMID 27325930›Full record

ArticleHeart Asia2010

Roles of ghrelin in left-ventricular remodelling after acute myocardial infarction.

Hideyuki Kondo, Yukihiro Hojo, Nozomu Takahashi, Tomokazu Ikemoto, Hirotaka Aoki, Katsuya Dezaki, Kazuomi Kario, Takaaki Katsuki, Toshihiko Yada, Kazuyuki Shimada

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heart Asia, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 88% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Hideyuki KondoDepartment of Cardiology, Jichi Medical University, Shimotsuke-city, Tochigi, Japan.
Yukihiro HojoDepartment of Cardiology, Jichi Medical University, Shimotsuke-city, Tochigi, Japan.
Nozomu TakahashiDepartment of Cardiology, Jichi Medical University, Shimotsuke-city, Tochigi, Japan.
Tomokazu IkemotoDepartment of Cardiology, Jichi Medical University, Shimotsuke-city, Tochigi, Japan.
Hirotaka AokiDepartment of Cardiology, Jichi Medical University, Shimotsuke-city, Tochigi, Japan.
Katsuya DezakiDivision of Integrative Physiology, Department of Physiology, Jichi Medical University, Shimotsuke-city, Tochigi, Japan.
Kazuomi KarioDepartment of Cardiology, Jichi Medical University, Shimotsuke-city, Tochigi, Japan.
Takaaki KatsukiDepartment of Cardiology, Jichi Medical University, Shimotsuke-city, Tochigi, Japan.
Toshihiko YadaDivision of Integrative Physiology, Department of Physiology, Jichi Medical University, Shimotsuke-city, Tochigi, Japan.
Kazuyuki ShimadaDepartment of Cardiology, Jichi Medical University, Shimotsuke-city, Tochigi, Japan.
Jichi Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe purpose of this study was to elucidate the role of ghrelin after acute myocardial infarction (AMI) in left ventricular (LV) remodelling.

designProspective observational study.

settingJichi Medical University Hospital. PATIENTS: Fifty consecutive patients experiencing their first AMI.

interventionsGhrelin was measured on the day of admission, day 7, day 14 and 6 months after AMI. Patients were treated by percutaneous coronary intervention, and successful myocardial reperfusion was accomplished within 12 h after onset. To analyse LV remodelling, the authors performed left ventriculographies on the day of admission and 6 months after AMI.

main outcome measuresChanges in LV volume.

resultsPlasma ghrelin increased significantly after AMI (admission: 40.9±7.3; day 7: 89.5±11.0; day 14: 92.6±11.8 fmol/ml, p<0.0001). There was a significant correlation between ghrelin on day 14 and changes in LV volume over 6 months (r=+0.46, p<0.001). Multivariate regression analysis showed that ghrelin on day 14 is a significant predictor of LV remodelling after AMI (β=+0.44, p=0.001).

conclusionTo our knowledge, this is the first report that shows a relation between circulating ghrelin after AMI and the progression of LV remodelling in the chronic phase. The elevation of ghrelin after AMI might be a compensatory mechanism to attenuate LV remodelling.

Indexed as

Acute coronary syndromeAcute coronary syndromesacute myocardial infarctionAMIBMIbody mass indexCPK-AUCC-reactive proteincreatine phosphokinase-area under the curveCRPGHGhrelingrowth hormoneIGF-1insulin-like growth factor-1left ventricularleft ventricular ejection fractionleft ventricular end-diastolic volume indexLVLVEDVILVEFMetabolismMyocardial ischaemiaPCIpercutaneous coronary interventionVentricular remodelling

Identifiers

PMID27325930
PMCPMC4898497
OpenAlexW2072056597

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.