ArticleProceedings of the National Academy of Sciences of the United States of America2016
BBX21, an Arabidopsis B-box protein, directly activates HY5 and is targeted by COP1 for 26S proteasome-mediated degradation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 125 papers, 1 of them a synthesis that pooled it.
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Who cites it
125 citing papers in PubMed, 1 synthesis or guideline pooled it, 284 citations in OpenAlex.
- Precise scheduling of B-box transcription factors: the core network for balancing plant growth, metabolism and stress resistance.Frontiers in plant science · 2026Pooled it
- BR-ENHANCED EXPRESSION 1/2/3 fine-tune plant photomorphogenesis by regulating the phyA/B-SPA1 cascade.The Plant cell · 2026Article
- Genome-Wide Characterization and Light-Responsive Expression Patterns of B-Box Transcription Factors inPlants (Basel, Switzerland) · 2026Article
- Functional Characterization ofInternational journal of molecular sciences · 2026Article
- SmYABBY1, a Light-Inducible Transcription Factor, Positively Regulates Anthocyanin Biosynthesis in Eggplant (International journal of molecular sciences · 2026Article
- Multifaceted roles of BBX transcription factors: impacts on key agronomical traits and environmental resilience.The New phytologist · 2026Review
- Identification of Novel Regulators of Fruit Sugar Accumulation Based on Transcriptome and WGCNA inInternational journal of molecular sciences · 2025Article
- Integrated transcriptomic and metabolomic analysis reveals regulatory mechanisms underlying coloration differences in the pericarps of two Litchi cultivars.Food chemistry. Molecular sciences · 2025Article
- The PavDREB1E-PavD8-PavHY5 module integrates light and gibberellin signals to regulate sweet cherry anthocyanin biosynthesis.Plant physiology · 2025Article
- Genome-wide analysis of PfBBXs transcription factors in Perilla frutescens and their expression responses to different light intensities.Plant molecular biology · 2025Article
- Genome-Wide Identification of the Litchi BBX Gene Family and Analysis of Its Potential Role in Pericarp Coloring.International journal of molecular sciences · 2025Article
- Gibberellin transport affects lateral root growth through HY5 in response to far-red light.The Plant cell · 2025Article
- Sensory Perception of Fluctuating Light in Arabidopsis.Plant, cell & environment · 2025Article
- Article
- Sporophyte-directed gametogenesis in Arabidopsis.Nature plants · 2025Article
- Unequal Genetic Redundancies Among MYC bHLH Transcription Factors Underlie Seedling Photomorphogenesis in Arabidopsis.Plant direct · 2025Article
- Revisiting the role of light signaling in plant responses to salt stress.Horticulture research · 2025Article
- The role of mediator subunit MED7 in Arabidopsis development.Frontiers in plant science · 2025Article
- A truncated B-box zinc finger transcription factor confers drought sensitivity in modern cultivated tomatoes.Nature communications · 2024Article
- Elucidating the Role ofInternational journal of molecular sciences · 2024Article
65 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 4 institutions in 2 countries.
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Abstract
BBX21 (also known as SALT TOLERANCE HOMOLOG 2), a B-box (BBX)-containing protein, has been previously identified as a positive regulator of light signaling; however, the precise role of BBX21 in regulating seedling photomorphogenesis remains largely unclear. In this study, we report that CONSTITUTIVELY PHOTOMORPHOGENIC 1 (COP1) interacts with BBX21 in vivo and is able to ubiquitinate BBX21 in vitro. Thus, BBX21 is targeted for 26S proteasome-mediated degradation in dark-grown Arabidopsis seedlings in a COP1-dependent manner. Moreover, we show that BBX21 binds to the T/G-box in the ELONGATED HYPOCOTYL 5 (HY5) promoter and directly activates HY5 expression in the light. Transgenic seedlings overexpressing BBX21 exhibit dramatically shortened hypocotyls in the light, and this phenotype is dependent on a functional HY5. Taken together, our data suggest a molecular base underlying BBX21-mediated seedling photomorphogenesis, indicating that BBX21 is a pivotal component involved in the COP1-HY5 regulatory hub.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.