ArticleProceedings of the National Academy of Sciences of the United States of America2016
Decoding and disrupting left midfusiform gyrus activity during word reading.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 2 of them syntheses that pooled it.
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Who cites it
70 citing papers in PubMed, 2 syntheses or guidelines pooled it, 141 citations in OpenAlex.
- Pooled it
- A contemporary framework of language processing in the human brain in the context of preoperative and intraoperative language mapping.Neuroradiology · 2017Pooled it
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- The reading brain - Transforming vision into language.Progress in neurobiology · 2026Review
- Medial Pulvinar Nucleus as a Causal Hub for Heteromodal Naming.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Posterior Cortical Atrophy: Altered Language Processing System Connectivity and Its Implications on Language Comprehension and Production.Brain sciences · 2025Article
- Neural correlates of reading aloud on the autism spectrum.Scientific reports · 2025Article
- Article
- Memorability of novel words correlates with anterior fusiform activity during reading.Nature communications · 2025Article
- Intracerebral Electrical Stimulation of the Left Occipito-Temporal Cortex Induces Pure Alexia.Neurobiology of language (Cambridge, Mass.) · 2025Article
- Bilateral Word Selectivity Gradients in the Visual Word Form System in Skilled Deaf Readers.Neurobiology of language (Cambridge, Mass.) · 2025Article
- Functional imaging derived ADHD biotypes based on deep clustering: a study on personalized medication therapy guidance.EClinicalMedicine · 2024Article
- Binding of cortical functional modules by synchronous high-frequency oscillations.Nature human behaviour · 2024Article
- Dissociation of reading and naming in ventral occipitotemporal cortex.Brain : a journal of neurology · 2024Article
- Interacting ventral temporal gradients of timescales and functional connectivity and their relationships to visual behavior.iScience · 2024Article
- The language network as a natural kind within the broader landscape of the human brain.Nature reviews. Neuroscience · 2024Review
- Investigating lexical categorization in reading based on joint diagnostic and training approaches for language learners.NPJ science of learning · 2024Article
- Linguistic and attentional factors - Not statistical regularities - Contribute to word-selective neural responses with FPVS-oddball paradigms.Cortex; a journal devoted to the study of the nervous system and behavior · 2024Article
- Dissociation between Selecting and Orienting Attentional Reading Deficits: A Study in Adults with Epilepsy.Brain sciences · 2024Article
- Better Together: Integrating Multivariate with Univariate Methods, and MEG with EEG to Study Language Comprehension.Language, cognition and neuroscience · 2024Article
10 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The nature of the visual representation for words has been fiercely debated for over 150 y. We used direct brain stimulation, pre- and postsurgical behavioral measures, and intracranial electroencephalography to provide support for, and elaborate upon, the visual word form hypothesis. This hypothesis states that activity in the left midfusiform gyrus (lmFG) reflects visually organized information about words and word parts. In patients with electrodes placed directly in their lmFG, we found that disrupting lmFG activity through stimulation, and later surgical resection in one of the patients, led to impaired perception of whole words and letters. Furthermore, using machine-learning methods to analyze the electrophysiological data from these electrodes, we found that information contained in early lmFG activity was consistent with an orthographic similarity space. Finally, the lmFG contributed to at least two distinguishable stages of word processing, an early stage that reflects gist-level visual representation sensitive to orthographic statistics, and a later stage that reflects more precise representation sufficient for the individuation of orthographic word forms. These results provide strong support for the visual word form hypothesis and demonstrate that across time the lmFG is involved in multiple stages of orthographic representation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.