Evidence map›Paper›PMID 27325752›Full record

ArticleThorax2017

Latrophilin receptors: novel bronchodilator targets in asthma.

A Faiz, C Donovan, M Ae Nieuwenhuis, M van den Berge, D S Postma, S Yao, C Y Park, R Hirsch, J J Fredberg, G Tjin and 14 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Thorax, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Runx2 Regulated Airway Homeostasis Is Disrupted in Asthma.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Integrative Genomics of Emphysema-Associated Genes Reveals Potential Disease Biomarkers.American journal of respiratory cell and molecular biology · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 14 institutions in 5 countries.

A FaizWoolcock Institute of Medical Research, The University of Sydney, Glebe, New South Wales, Australia.
C DonovanDepartment of Pharmacology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
M Ae NieuwenhuisUniversity of Groningen, University Medical Center Groningen, Department of Pulmonary Diseases, Groningen, The Netherlands.
M van den BergeUniversity of Groningen, University Medical Center Groningen, Department of Pulmonary Diseases, Groningen, The Netherlands.
D S PostmaUniversity of Groningen, University Medical Center Groningen, Department of Pulmonary Diseases, Groningen, The Netherlands.
S YaoCenter for Vascular Biology Research, Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
C Y ParkProgram in Molecular and Integrative Physiological Sciences, Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
R HirschProgram in Molecular and Integrative Physiological Sciences, Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
J J FredbergProgram in Molecular and Integrative Physiological Sciences, Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
G TjinWoolcock Institute of Medical Research, The University of Sydney, Glebe, New South Wales, Australia.
A J HalaykoManitoba Institute of Child Health, University of Manitoba, Winnipeg, Manitoba, Canada.
K L RempelManitoba Institute of Child Health, University of Manitoba, Winnipeg, Manitoba, Canada.
J P T WardKings College London, London, UK.
T LeeKings College London, London, UK.
Y BosséDepartment of Molecular Medicine, Institut universitaire de cardiologie et de pneumologie de Québec, Laval University, Québec, Quebec, Canada.
D C NickleMerck Research Laboratories, Genetics and Pharmacogenomics, Boston, Massachusetts, USA.
M ObeidatCentre for Heart Lung Innovation, University of British Columbia, St. Paul's Hospital, Vancouver, British Columbia, Canada.
Judith M VonkUniversity of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, The Netherlands.
J L BlackWoolcock Institute of Medical Research, The University of Sydney, Glebe, New South Wales, Australia.
B G OliverWoolcock Institute of Medical Research, The University of Sydney, Glebe, New South Wales, Australia.
R KrishnanCenter for Vascular Biology Research, Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
B McParlandDiscipline of Pharmacology, Faculty of Medicine, The University of Sydney, Sydney, New South Wales, Australia.
J E BourkeDepartment of Pharmacology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
J K BurgessWoolcock Institute of Medical Research, The University of Sydney, Glebe, New South Wales, Australia.
University Medical Center Groningen · NLUniversity of Groningen · NLKing's College London · GBThe University of Sydney · AUWoolcock Institute of Medical Research · AUAustralian Regenerative Medicine Institute · AUBeth Israel Deaconess Medical Center · USCenter for Vascular Biology Research · USChildren's Hospital Research Institute of Manitoba · CAInstitut universitaire de cardiologie et de pneumologie de Québec · CAMerck & Co., Inc., Rahway, NJ, USA (United States) · USThe University of Melbourne · AUUniversity of British Columbia · CAUniversity of Manitoba · CA

Funding

Physics of collective cellular migration in lung health and diseaseP01HL120839 · NHLBI · HARVARD SCHOOL OF PUBLIC HEALTH · PI FREDBERG, JEFFREY J · 2014 to 2018
$12.2M
NHLBI NIH HHS P01 HL120839
6 · The paper itself

Abstract

backgroundAsthma affects 300 million people worldwide. In asthma, the major cause of morbidity and mortality is acute airway narrowing, due to airway smooth muscle (ASM) hypercontraction, associated with airway remodelling. However, little is known about the transcriptional differences between healthy and asthmatic ASM cells.

objectivesTo investigate the transcriptional differences between asthmatic and healthy airway smooth muscle cells (ASMC) in culture and investigate the identified targets using in vitro and ex vivo techniques.

methodsHuman asthmatic and healthy ASMC grown in culture were run on Affymetrix_Hugene_1.0_ST microarrays. Identified candidates were confirmed by PCR, and immunohistochemistry. Functional analysis was conducted using in vitro ASMC proliferation, attachment and contraction assays and ex vivo contraction of mouse airways.

resultsWe suggest a novel role for latrophilin (LPHN) receptors, finding increased expression on ASMC from asthmatics, compared with non-asthmatics in vivo and in vitro, suggesting a role in mediating airway function. A single nucleotide polymorphism in LPHN1 was associated with asthma and with increased LPHN1 expression in lung tissue. When activated, LPHNs regulated ASMC adhesion and proliferation in vitro, and promoted contraction of mouse airways and ASMC.

conclusionsGiven the need for novel inhibitors of airway remodelling and bronchodilators in asthma, the LPHN family may represent promising novel targets for future dual therapeutic intervention.

Indexed as

AcetylcholineAnimalsAsthmaCase-Control StudiesCell AdhesionCell ProliferationCells, CulturedHumansMaleMembrane GlycoproteinsMembrane ProteinsMiceMice, Inbred BALB CMuscle ContractionMyocytes, Smooth MuscleOligonucleotide Array Sequence AnalysisAcetylcholineADGRL1 protein, humanAdgrl1 protein, mouseADGRL3 protein, humanAdgrl3 protein, mousealpha-latrotoxinFLRT3 protein, humanMembrane GlycoproteinsMembrane ProteinsReceptors, G-Protein-CoupledReceptors, PeptideSpider VenomsAsthmaAsthma Genetics

Identifiers

PMID27325752
PMCPMC5329048
OpenAlexW2469676477

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.