ArticleJournal of bacteriology2016
A Suppressor Mutation That Creates a Faster and More Robust σE Envelope Stress Response.
Article in Journal of bacteriology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- ModelingbioRxiv : the preprint server for biology · 2025Article
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- Heat stress induces phage tolerance ineLife · 2025Article
- Analysis of Osmotic Tolerance, Physiological Characteristics, and Gene Expression ofACS omega · 2023Article
- Time-Dependent Biosensor Fluorescence as a Measure of Bacterial Arsenic Uptake Kinetics and Its Inhibition by Dissolved Organic Matter.Applied and environmental microbiology · 2022Article
- Homeostasis of the Gram-negative cell envelope.Current opinion in microbiology · 2021Review
- Countering Gram-Negative Antibiotic Resistance: Recent Progress in Disrupting the Outer Membrane with Novel Therapeutics.Antibiotics (Basel, Switzerland) · 2019Review
- Envelope stress responses: balancing damage repair and toxicity.Nature reviews. Microbiology · 2019Review
- Fine-Tuning of σJournal of bacteriology · 2019Article
- The Synthetic Phenotype of ΔmBio · 2019Article
- Improper Coordination of BamA and BamD Results in Bam Complex Jamming by a Lipoprotein Substrate.mBio · 2019Article
- Article
- Inhibitor of intramembrane protease RseP blocks the σProceedings of the National Academy of Sciences of the United States of America · 2018Article
- Outer Membrane Biogenesis.Annual review of microbiology · 2017Review
- Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
unlabelledThe σE envelope stress response is an essential signal transduction pathway which detects and removes mistargeted outer membrane (OM) β-barrel proteins (OMPs) in the periplasm of Escherichia coli It relies on σE, an alternative sigma factor encoded by the rpoE gene. Here we report a novel mutation, a nucleotide change of C to A in the third base of the second codon, which increases levels of σE (rpoE_S2R). The rpoE_S2R mutation does not lead to the induction of the stress response during normal growth but instead changes the dynamics of induction upon periplasmic stress, resulting in a faster and more robust response. This allows cells to adapt faster to the periplasmic stress, avoiding lethal accumulation of unfolded OMPs in the periplasm caused by severe defects in the OMP assembly pathway. IMPORTANCE: Survival of bacteria under conditions of external or internal stresses depends on timely induction of stress response signaling pathways to regulate expression of appropriate genes that function to maintain cellular homeostasis. Previous studies have shown that strong preinduction of envelope stress responses can allow bacteria to survive a number of lethal genetic perturbations. In our paper, we describe a unique mutation that enhances kinetics of the σE envelope stress response pathway rather than preinducing the response. This allows bacteria to quickly adapt to sudden and severe periplasmic stress.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.