Evidence map›Paper›PMID 27325435›Full record

ArticleThe Journal of allergy and clinical immunology2016

Ozone primes alveolar macrophage-derived innate immunity in healthy human subjects.

Benjamin W Frush, Zhuowei Li, Jane V Stiles, Sarah F Cotter, Scott L Shofer, W Michael Foster, John W Hollingsworth, Robert M Tighe

Abstract readLetter
In one paragraph

Article in The Journal of allergy and clinical immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Role of Macrophages in Air Pollution Exposure Related Asthma.International journal of molecular sciences · 2022
    Review
  9. Role of Innate Immune System in Environmental Lung Diseases.Current allergy and asthma reports · 2021
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Advances in environmental and occupational disorders in 2016.The Journal of allergy and clinical immunology · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Benjamin W FrushDepartment of Medicine, Duke University Medical Center, Durham, NC.
Zhuowei LiDepartment of Medicine, Duke University Medical Center, Durham, NC.
Jane V StilesDepartment of Medicine, Duke University Medical Center, Durham, NC.
Sarah F CotterDepartment of Medicine, Duke University Medical Center, Durham, NC.
Scott L ShoferDepartment of Medicine, Duke University Medical Center, Durham, NC.
W Michael FosterDepartment of Medicine, Duke University Medical Center, Durham, NC.
John W HollingsworthDepartment of Medicine, Duke University Medical Center, Durham, NC.
Robert M TigheDepartment of Medicine, Duke University Medical Center, Durham, NC. Electronic address: robert.tighe@duke.edu.

Funding

Surfactant Protein-A Regulation of Innate Immunityin AsthmaP01AI081672 · NIAID · DUKE UNIVERSITY · PI KRAFT, MONICA · 2009 to 2013
$7.4M
OZONE PRIMES PULMONARY INNATE IMMUNITYR01ES016126 · NIEHS · OHIO STATE UNIVERSITY · PI HOLLINGSWORTH, JOHN W · 2008 to 2012
$2.3M
EXTRACELLULAR MATRIX, INNATE IMMUNITY, AND OZONE-INDUCED AIRWAYS DISEASER01ES020350 · NIEHS · OHIO STATE UNIVERSITY · PI WEWERS, MARK DAMIAN · 2012 to 2016
$2.0M
Regulation of Lung Fibrosis by Alternatively Activated Macrophages and Arginase-1K08HL105537 · NHLBI · DUKE UNIVERSITY · PI TIGHE, ROBERT MATTHEW · 2012 to 2016
$492k
NHLBI NIH HHS K08 HL105537NIAID NIH HHS P01 AI081672NIEHS NIH HHS R01 ES016126NIEHS NIH HHS R01 ES020350
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Administration, InhalationAdultAnimalsFemaleHealthy VolunteersHumansImmunity, InnateIn Vitro TechniquesLipopolysaccharide ReceptorsLipopolysaccharidesMacrophages, AlveolarMaleMiceOzoneRNA, MessengerTetradecanoylphorbol AcetateLipopolysaccharide ReceptorsLipopolysaccharidesOzoneRNA, MessengerTetradecanoylphorbol AcetateTLR4 protein, humanToll-Like Receptor 4

Identifiers

PMID27325435
PMCPMC5056795

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.