Evidence map›Paper›PMID 27325434›Full record

ArticleThe Journal of allergy and clinical immunology2017

Follicular helper T cells mediate IgE antibody response to airborne allergens.

Takao Kobayashi, Koji Iijima, Alexander L Dent, Hirohito Kita

Abstract read
In one paragraph

Article in The Journal of allergy and clinical immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 125 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
125citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

125 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. A Comprehensive Review of Kimura Disease.Head and neck pathology · 2025
    Pooled it
  2. Context-dependent regulation of mast cell-mediated food allergy in C57BL/6J mice.The Journal of allergy and clinical immunology · 2026
    Article
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  15. Sex Differences in Lung B Cell Responses in a Murine Model of Asthma.International archives of allergy and immunology · 2026
    Article
  16. Circulating TFH2 Cell Expansion and GZMKJournal of asthma and allergy · 2026
    Article
  17. Article
  18. Article
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  20. Article

65 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Takao KobayashiDepartment of Medicine and Immunology, Mayo Clinic Rochester, Rochester, Minn.
Koji IijimaDepartment of Medicine and Immunology, Mayo Clinic Rochester, Rochester, Minn.
Alexander L DentDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Ind.
Hirohito KitaDepartment of Medicine and Immunology, Mayo Clinic Rochester, Rochester, Minn. Electronic address: kita.hirohito@mayo.edu.

Funding

Alternaria and ribonucleases in Th2-type immunityR01AI071106 · NIAID · MAYO CLINIC ROCHESTER · PI KITA, HIROHITO · 2008 to 2017
$4.0M
NIAID NIH HHS R01 AI071106
6 · The paper itself

Abstract

backgroundT

objectiveWe sought to investigate the roles of T

methodsNaive mice were exposed to cytokines or natural allergens through the airways. Development of allergic immune responses was analyzed by collecting draining lymph nodes and sera and by challenging the animals. Cytokine reporter mice and gene-deficient mice were used to dissect the immunologic mechanisms.

resultsWe observed the development of IL-4-producing T

conclusionT

Indexed as

Air PollutantsAllergensAnimalsBronchoalveolar Lavage FluidCell CountCytokinesFemaleImmunoglobulin EImmunoglobulin GLungMice, Inbred BALB CMice, Inbred C57BLMice, TransgenicOvalbuminRespiratory HypersensitivityT-Lymphocytes, Helper-InducerAir PollutantsAllergensCytokinesImmunoglobulin EImmunoglobulin GOvalbuminallergensallergyFollicular T cellsIgEIL-4T(H)2 cells

Identifiers

PMID27325434
PMCPMC5115999

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.