ArticleGut2017
The TRPA1 ion channel is expressed in CD4+ T cells and restrains T-cell-mediated colitis through inhibition of TRPV1.
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In one paragraph
Article in Gut, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed, 1 pooled it
8.1field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
75 citing papers in PubMed, 1 synthesis or guideline pooled it, 142 citations in OpenAlex.
- The Role of TRP Channels in Colitis and Inflammatory Bowel Disease: A Systematic Review.International journal of molecular sciences · 2025Pooled it
- Article
- Neuro-immune interactions in gastrointestinal oncology: Mechanisms, challenges, and therapeutic potential.Innovation (Cambridge (Mass.)) · 2026Review
- Effects of Thermal Stress on Growth and Reproduction ofAnimals : an open access journal from MDPI · 2026Review
- Immunometabolic and immune regulatory functions of capsaicin in cancer: mechanistic insights and emerging perspectives.Frontiers in immunology · 2026Review
- Dietary targeting of TRPM8 rewires macrophage immunometabolism reducing colitis severity.Cell death & disease · 2025Article
- Febrile temperature-regulated TRPV1 in CD4Journal of neuroinflammation · 2025Article
- Gastric Carcinogenesis and Potential Role of the Transient Receptor Potential Vanilloid 1 (TRPV1) Receptor: An Observational Histopathological Study.International journal of molecular sciences · 2024Observational
- Dynamic Changes in Ion Channels during Myocardial Infarction and Therapeutic Challenges.International journal of molecular sciences · 2024Review
- TRPA1 Covalent Ligand JT010 Modifies T Lymphocyte Activation.Biomolecules · 2024Article
- The Role of TRP Channels in Sepsis and Colitis.International journal of molecular sciences · 2024Review
- Pathophysiological Roles of Ion Channels in Epidermal Cells, Immune Cells, and Sensory Neurons in Psoriasis.International journal of molecular sciences · 2024Review
- TRP Ion Channels in Immune Cells and Their Implications for Inflammation.International journal of molecular sciences · 2024Review
- Research Progress on TRPA1 in Diseases.The Journal of membrane biology · 2023Review
- Mechanosensitive Ion Channels: Their Physiological Importance and Potential Key Role in Cancer.International journal of molecular sciences · 2023Review
- Tumor-derived interleukin-1 receptor antagonist exhibits immunosuppressive functions and promotes pancreatic cancer.Cell & bioscience · 2023Article
- TRPA1 activation and Hsp90 inhibition synergistically downregulate macrophage activation and inflammatory responses in vitro.BMC immunology · 2023Article
- Review
- Ion channel regulation of gut immunity.The Journal of general physiology · 2023Article
- Expression and functions of transient receptor potential channels in liver diseases.Acta pharmaceutica Sinica. B · 2023Review
15 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 4 institutions in 2 countries.
Samuel BertinDivision of Rheumatology, Allergy & Immunology, Department of Medicine, University of California San Diego, La Jolla, California, USA.
Yukari Aoki-NonakaDivision of Rheumatology, Allergy & Immunology, Department of Medicine, University of California San Diego, La Jolla, California, USA.
Jihyung LeeDivision of Rheumatology, Allergy & Immunology, Department of Medicine, University of California San Diego, La Jolla, California, USA.
Petrus R de JongDivision of Rheumatology, Allergy & Immunology, Department of Medicine, University of California San Diego, La Jolla, California, USA.
Peter KimDivision of Rheumatology, Allergy & Immunology, Department of Medicine, University of California San Diego, La Jolla, California, USA.
Tiffany HanDivision of Rheumatology, Allergy & Immunology, Department of Medicine, University of California San Diego, La Jolla, California, USA.
Timothy YuDivision of Rheumatology, Allergy & Immunology, Department of Medicine, University of California San Diego, La Jolla, California, USA.
Keith ToDivision of Rheumatology, Allergy & Immunology, Department of Medicine, University of California San Diego, La Jolla, California, USA.
Naoki TakahashiDivision of Rheumatology, Allergy & Immunology, Department of Medicine, University of California San Diego, La Jolla, California, USA.
Brigid S BolandDivision of Gastroenterology, Department of Medicine, University of California San Diego, La Jolla, California, USA.
John T ChangDivision of Gastroenterology, Department of Medicine, University of California San Diego, La Jolla, California, USA.
Samuel B HoDivision of Gastroenterology, Department of Medicine, University of California San Diego, La Jolla, California, USA.
Scott HerdmanDivision of Rheumatology, Allergy & Immunology, Department of Medicine, University of California San Diego, La Jolla, California, USA.
Maripat CorrDivision of Rheumatology, Allergy & Immunology, Department of Medicine, University of California San Diego, La Jolla, California, USA.
Alessandra FrancoDepartment of Pediatrics, University of California San Diego, La Jolla, California, USA.
Sonia SharmaLa Jolla Institute for Allergy and Immunology, La Jolla, California, USA.
Hui DongDivision of Gastroenterology, Department of Medicine, University of California San Diego, La Jolla, California, USA.
Armen N AkopianDepartment of Endodontics, UTHSCSA, San Antonio, Texas, USA.
Eyal RazDivision of Rheumatology, Allergy & Immunology, Department of Medicine, University of California San Diego, La Jolla, California, USA.
University of California, San Diego · USLa Jolla Institute for Immunology · USNiigata University · JPThe University of Texas Health Science Center at San Antonio · US
Funding
VirologyP30AI036214 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI David Mitchell Smith · 1994 to 2026
$78.4MTL MOLECULES AND GAMMA-DELTA T CELLSP01DK035108 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI RAZ, EYAL · 1986 to 2013
$19.2MUC San Diego Clinical and Translational Research InstituteKL2TR001444 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DEPP, COLIN A. · 2015 to 2024
$15.4MU of Calif, San Diego Neuroscience Microscopy ImagingP30NS047101 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GLEESON, JOSEPH G, ZHENG, BINHAI · 2003 to 2022
$9.0MTraining Grant in GastroenterologyT32DK007202 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GHOSH, PRADIPTA · 1985 to 2022
$7.7MRegulation and Function of Polarity and Asymmetric Cell Division in ImmunityR01AI095277 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHANG, JOHN T · 2012 to 2016
$2.6MControl of mucosal immunity by Gas- vs Gai-linked GPCR signaling in dendritic cellsU01AI125860 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI RAZ, EYAL · 2016 to 2020
$2.3MTargeting tumor endothelium for cancer surveillance and immunotherapyR01CA199376 · NCI · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI SHARMA, SONIA · 2015 to 2019
$2.0MRole of atypical Protein Kinase C in Inflammatory Bowel DiseaseR01DK093507 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHANG, JOHN T · 2012 to 2016
$1.7MTh17 subsets: Differential roles in immune defense mechanisms at the G-I mucosaU01AI095623 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI RAZ, EYAL · 2011 to 2015
$1.6MProlactin regulation of postoperative pain in males and femalesR01GM112747 · NIGMS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI AKOPIAN, ARMEN N · 2015 to 2018
$1.2MMechanisms of airway neurogenic inflammation by asthma-inducing allergensR21AI101325 · NIAID · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI AKOPIAN, ARMEN N · 2012 to 2013
$362kNCATS NIH HHS KL2 TR001444NCI NIH HHS R01 CA199376NIAID NIH HHS P30 AI036214NIAID NIH HHS R01 AI095277NIAID NIH HHS R21 AI101325NIAID NIH HHS U01 AI095623NIAID NIH HHS U01 AI125860NIDDK NIH HHS P01 DK035108NIDDK NIH HHS R01 DK093507NIDDK NIH HHS T32 DK007202NIGMS NIH HHS R01 GM112747NINDS NIH HHS P30 NS047101
Abstract
objectiveTransient receptor potential ankyrin-1 (TRPA1) and transient receptor potential vanilloid-1 (TRPV1) are calcium (Ca
designWe evaluated the role of
resultsWe identified a protective role for TRPA1 in T-cell-mediated colitis. We demonstrated the functional expression of TRPA1 on the plasma membrane of CD4+ T cells and identified that
conclusionsOur study indicates that TRPA1 inhibits TRPV1 channel activity in CD4+ T cells, and consequently restrains CD4+ T-cell activation and colitogenic responses. These findings may therefore have therapeutic implications for human IBD.
Indexed as
ColitisInflammatory Bowel DiseasesTransient Receptor Potential ChannelsTRPV Cation ChannelsAnimalsBiopsyCD4-Positive T-LymphocytesCells, CulturedColonDisease Models, AnimalGene ExpressionHumansMiceProtective FactorsStatistics as TopicTRPA1 Cation ChannelTransient Receptor Potential ChannelsTRPA1 Cation ChannelTrpa1 protein, mouseTRPV1 protein, mouseTRPV Cation ChannelsCALCIUMEXPERIMENTAL COLITISIBDION CHANNELST LYMPHOCYTES
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.