ArticleAging cell2016
GWAS analysis of handgrip and lower body strength in older adults in the CHARGE consortium.
Registry-linked trialOpen access · goldAbstract read
In one paragraph
Article in Aging cell, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07253714 (THE EFFECT OF PROPRIOCEPTIVE EXERCISE TRAINING ON CERVICAL PROPRIOCEPTION, KINESIOPHOBIA, AND PAIN CATASTROPHIZING LEVELS IN SARCOPENIC GERIATRIC INDIVIDUALS RESIDING IN NURSING HOMES), which is not on this map. Cited by 41 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 2 pooled it
6.0field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The effect of proprioceptive exercise training on cervical proprioception, kinesiophobia, and pain catastrophizing levels in sarcopenic geriatric individuals residing in nursing homes
Who cites it
41 citing papers in PubMed, 2 syntheses or guidelines pooled it, 64 citations in OpenAlex.
- The phenotypic and genotypic association of grip strength with frailty, physical performance and functional limitations over time in older adults.Age and ageing · 2023Pooled it
- Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women.Nature communications · 2021Pooled it
- Loss ofiScience · 2026Article
- CRISPR-Cas9: bridging the gap between aging mechanisms and therapeutic advances in neurodegenerative disorders.Frontiers in cellular neuroscience · 2025Review
- TheMetabolites · 2024Article
- A GWAS for grip strength in cohorts of children-Advantages of analysing young participants for this trait.Genes, brain, and behavior · 2024Article
- Enhanced fracture risk prediction: a novel multi-trait genetic approach integrating polygenic scores of fracture-related traits.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2024Article
- Whole Genome Linkage and Association Analyses Identify DLG Associated Protein-1 as a Novel Positional and Biological Candidate Gene for Muscle Strength: The Long Life Family Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- A genome-wide association study identifies a locus associated with knee extension strength in older Japanese individuals.Communications biology · 2024Article
- Epigenome-wide association study identifies DNA methylation loci associated with handgrip strength in Chinese monozygotic twins.Frontiers in cell and developmental biology · 2024Article
- The ROSMAP project: aging and neurodegenerative diseases through omic sciences.Frontiers in neuroinformatics · 2024Review
- Familial Correlation and Heritability of Hand Grip Strength in Korean Adults (Korea National Health and Nutrition Examination Survey 2014 to 2019).Endocrinology and metabolism (Seoul, Korea) · 2023Article
- Causal associations between hand grip strength and pulmonary function: a two-sample Mendelian randomization study.BMC pulmonary medicine · 2023Article
- The Health, Aging, and Body Composition (Health ABC) Study-Ground-Breaking Science for 25 Years and Counting.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Review
- Genes and Athletic Performance: The 2023 Update.Genes · 2023Review
- Review
- Grip strength is inversely associated with DNA methylation age acceleration.Journal of cachexia, sarcopenia and muscle · 2023Article
- Lifetime serum concentration of 25-hydroxyvitamin D 25(OH) is associated with hand grip strengths: insight from a Mendelian randomisation.Age and ageing · 2022Article
- Epigenome-wide association study of sarcopenia: findings from the Hertfordshire Sarcopenia Study (HSS).Journal of cachexia, sarcopenia and muscle · 2022Article
- The genetics of human performance.Nature reviews. Genetics · 2022Review
Corrections and comments
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Authors and funding
67 authors at 20 institutions in 10 countries.
Amy M MatteiniDivision of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Toshiko TanakaLongitudinal Studies Section, Translational Gerontology Branch, Gerontology Research Center, National Institute on Aging, Baltimore, MD, USA.
David KarasikInstitute for Aging Research, Hebrew SeniorLife, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.
Gil AtzmonInstitute for Aging Research Departments of Medicine and Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY, USA.
Wen-Chi ChouInstitute for Aging Research, Hebrew SeniorLife, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.
John D EicherNational Heart, Lung and Blood Institute, Population Sciences Branch, Bethesda, MD, USA.
Andrew D JohnsonNational Heart, Lung and Blood Institute, Population Sciences Branch, Bethesda, MD, USA.
Alice M ArnoldDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
Michele L CallisayaStroke and Ageing Research Group, Department of Medicine, School of Clinical Sciences, Monash University, Clayton, Vic., Australia.
Gail DaviesCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
Daniel S EvansCalifornia Pacific Medical Center Research Institute, San Francisco, CA, USA.
Birte HoltfreterUnit of Periodontology, Department of Restorative Dentistry, Periodontology and Endodontology, Centre of Oral Health, University Medicine Greifswald, Greifswald, Germany.
Kurt LohmanCenter for Human Genetics, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Kathryn L LunettaNational Heart, Lung and Blood Institute's The Framingham Heart Study, Framingham, MA, USA.
Massimo ManginoDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Albert V SmithIcelandic Heart Association, Kopavogur, Iceland.
Jennifer A SmithDepartment of Epidemiology, University of Michigan, Ann Arbor, MI, USA.
Alexander TeumerInstitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Lei YuRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
Dan E ArkingMcKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Aron S BuchmanRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
Lori B ChibinikProgram in Translational NeuroPsychiatric Genomics, Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA.
Philip L De JagerProgram in Translational NeuroPsychiatric Genomics, Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA.
Denis A EvansInstitute of Healthy Aging and Department of Internal Medicine, Rush University Medical Center, Chicago, IL, USA.
Jessica D FaulSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
Melissa E GarciaLaboratory of Epidemiology and Population Science, National Institute on Aging, Bethesda, MD, USA.
Irina Gillham-NasenyaDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Vilmundur GudnasonIcelandic Heart Association, Kopavogur, Iceland.
Albert HofmanDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
Yi-Hsiang HsuInstitute for Aging Research, Hebrew SeniorLife, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.
Till IttermannInstitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Lies LahousseDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
David C LiewaldCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
Yongmei LiuCenter for Human Genetics, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Lorna LopezDepartment of Psychology, University of Edinburgh, Edinburgh, UK.
Fernando RivadeneiraDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
Jerome I RotterDivision of Genomic Outcome, Departments of Pediatrics and Medicine, Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, University of California Los Angeles, Los Angeles, CA, USA.
Kristin SiggeirsdottirIcelandic Heart Association, Kopavogur, Iceland.
John M StarrCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
Russell ThomsonMenzies Institute for Medical Research, University of Tasmania, Hobart, Tas., Australia.
Gregory J TranahCalifornia Pacific Medical Center Research Institute, San Francisco, CA, USA.
André G UitterlindenDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
Uwe VölkerInterfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.
Henry VölzkeInstitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
David R WeirSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
Kristine YaffeDepartments of Neurology, Psychiatry and Epidemiology & Biostatistics, University of California, San Francisco and the San Francisco Veterans Affairs Medical Center, San Francisco, CA, USA.
Wei ZhaoDepartment of Epidemiology, University of Michigan, Ann Arbor, MI, USA.
Wei Vivian ZhuangPublic Health Program, Center for Health Policy and Ethics, Creighton University School of Medicine, Omaha, NE, USA.
Joseph M ZmudaDepartment of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA.
David A BennettRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
Steven R CummingsCalifornia Pacific Medical Center Research Institute, San Francisco, CA, USA.
Ian J DearyCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
Luigi FerrucciLongitudinal Studies Section, Translational Gerontology Branch, Gerontology Research Center, National Institute on Aging, Baltimore, MD, USA.
Tamara B HarrisLaboratory of Epidemiology and Population Science, NIA, Bethesda, MD, USA.
Sharon L R KardiaDepartment of Epidemiology, University of Michigan, Ann Arbor, MI, USA.
Thomas KocherUnit of Periodontology, Department of Restorative Dentistry, Periodontology and Endodontology, Centre of Oral Health, University Medicine Greifswald, Greifswald, Germany.
Stephen B KritchevskySticht Center on Aging, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Bruce M PsatyCardiovascular Health Research Unit and Department of Medicine, University of Washington and Group Health Research Institute, Group Health Cooperative, Seattle, WA, USA.
Sudha SeshadriNational Heart, Lung and Blood Institute's The Framingham Heart Study, Framingham, MA, USA.
Timothy D SpectorDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Velandai K SrikanthStroke and Ageing Research Group, Department of Medicine, School of Clinical Sciences, Monash University, Clayton, Vic., Australia.
B Gwen WindhamDepartment of Medicine/Division of Geriatrics, University of Mississippi Medical Center, Jackson, MS, USA.
M Carola ZillikensDepartment of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands.
Anne B NewmanDepartment of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA.
Jeremy D WalstonDivision of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Douglas P KielInstitute for Aging Research, Hebrew SeniorLife, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.
Joanne M MurabitoNational Heart, Lung and Blood Institute's The Framingham Heart Study, Framingham, MA, USA.
Universitätsmedizin Greifswald · DEUniversity of Edinburgh · GBCalifornia Pacific Medical Center · USErasmus MC · NLUniversity of Michigan · USNational Heart Lung and Blood Institute · USNational Institute on Aging · USRush University Medical Center · USHebrew SeniorLife · USIcelandic Heart Association · ISJohns Hopkins University · USKing's College London · GBUniversity of Pittsburgh · USUniversity of Tasmania · AUWake Forest University · USAlbert Einstein College of Medicine · USBar-Ilan University · ILBoston University · USBrigham and Women's Hospital · USBroad Institute · US
Funding
HRS Yrs29-34: Y33 SSA CoFundingU01AG009740 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jessica Faul, KENNETH M LANGA · 1990 to 2026
$555.8MUCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1MSystems BiologyU19AG023122 · NIA · TRANSLATIONAL GENOMICS RESEARCH INST · PI NICHOLAS Joseph SCHORK · 2004 to 2026
$102.6MTHE FRAMINGHAM HEART STUDYN01HC25195 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI RAMACHANDRAN, VASAN S · 2007 to 2014
$83.8MInstitute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8MOREGON CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR024140 · NCRR · OREGON HEALTH & SCIENCE UNIVERSITY · PI ORWOLL, ERIC S. · 2006 to 2011
$61.1MUCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0MSUPPLEMENT TO RUSH ALZHEIMERS DISEASE CENTER COREP30AG010161 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI GLOVER, CRYSTAL M · 1991 to 2020
$49.1MEPIDEMIOLOGY OF NEURAL RESERVE AND NEUROBIOLOGY IN AGINGR01AG017917 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2001 to 2023
$43.3MTransgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PETER J TONTONOZ · 2003 to 2026
$40.4MTechnological Assessment and Solutions Core - RC4P30AG021334 · NIA · JOHNS HOPKINS UNIVERSITY · PI Jeremy D Walston · 2003 to 2026
$33.2MVARIABILITY, STABILITY & SMOOTHNESS OF WALKINGP30AG024827 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JENNIFER S BRACH · 2004 to 2026
$28.6MBiotechnology and Biological Sciences Research CouncilMedical Research Council MR/K026992/1NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1 TR001881NCRR NIH HHS UL1 RR024140NCRR NIH HHS UL1 RR025005NHGRI NIH HHS HHSN268200782096CNHGRI NIH HHS U01 HG004402NHLBI NIH HHS HHSN268200800007CNHLBI NIH HHS HHSN268201100005CNHLBI NIH HHS HHSN268201100006CNHLBI NIH HHS HHSN268201100007CNHLBI NIH HHS HHSN268201100008CNHLBI NIH HHS HHSN268201100009CNHLBI NIH HHS HHSN268201100010CNHLBI NIH HHS HHSN268201100011CNHLBI NIH HHS HHSN268201100012CNHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS N01 HC025195NHLBI NIH HHS N01 HC055222NHLBI NIH HHS N01 HC085079NHLBI NIH HHS N01 HC085080NHLBI NIH HHS N01 HC085081NHLBI NIH HHS N01 HC085082NHLBI NIH HHS N01 HC085083NHLBI NIH HHS N01 HC085086NHLBI NIH HHS N01HC25195NHLBI NIH HHS N01HC55222NHLBI NIH HHS N01HC85079NHLBI NIH HHS N01HC85080NHLBI NIH HHS N01HC85081NHLBI NIH HHS N01HC85082NHLBI NIH HHS N01HC85083NHLBI NIH HHS N02 HL064278NHLBI NIH HHS N02 HL64278NHLBI NIH HHS R01 HL059367NHLBI NIH HHS R01 HL086694NHLBI NIH HHS R01 HL087641NHLBI NIH HHS R01 HL103612NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL120393NHLBI NIH HHS U01 HL080295NIAMS NIH HHS R01 AR035582NIAMS NIH HHS R01 AR035583NIAMS NIH HHS R01 AR035584NIAMS NIH HHS R01 AR041398NIAMS NIH HHS R01 AR051124NIAMS NIH HHS RC2 AR058973NIAMS NIH HHS U01 AR045580NIAMS NIH HHS U01 AR045583NIAMS NIH HHS U01 AR045614NIAMS NIH HHS U01 AR045632NIAMS NIH HHS U01 AR045647NIAMS NIH HHS U01 AR045654NIAMS NIH HHS U01 AR066160NIA NIH HHS HHSN271201200022CNIA NIH HHS N01 AG012100NIA NIH HHS N01 AG062101NIA NIH HHS N01 AG062103NIA NIH HHS N01 AG062106NIA NIH HHS N01AG12100NIA NIH HHS P30 AG010161NIA NIH HHS P30 AG021334NIA NIH HHS P30 AG024827NIA NIH HHS R01 AG005394NIA NIH HHS R01 AG005407NIA NIH HHS R01 AG008122NIA NIH HHS R01 AG015819NIA NIH HHS R01 AG016495NIA NIH HHS R01 AG017917NIA NIH HHS R01 AG023629NIA NIH HHS R01 AG024480NIA NIH HHS R01 AG027574NIA NIH HHS R01 AG027576NIA NIH HHS R01 AG029451NIA NIH HHS R01 AG030146NIA NIH HHS R01 AG032098NIA NIH HHS R01 AG033193NIA NIH HHS R01 AG040039NIA NIH HHS R56 AG029451NIA NIH HHS RC1 AG035835NIA NIH HHS RC2 AG036495NIA NIH HHS RF1 AG015819NIA NIH HHS U01 AG009740NIA NIH HHS U01 AG018197NIA NIH HHS U01 AG027810NIA NIH HHS U19 AG023122NIA NIH HHS U24 AG051129NIDDK NIH HHS P30 DK063491NIMHD NIH HHS R01 MD009164Wellcome TrustWellcome Trust FP7/2007–2013
Abstract
Decline in muscle strength with aging is an important predictor of health trajectory in the elderly. Several factors, including genetics, are proposed contributors to variability in muscle strength. To identify genetic contributors to muscle strength, a meta-analysis of genomewide association studies of handgrip was conducted. Grip strength was measured using a handheld dynamometer in 27 581 individuals of European descent over 65 years of age from 14 cohort studies. Genomewide association analysis was conducted on ~2.7 million imputed and genotyped variants (SNPs). Replication of the most significant findings was conducted using data from 6393 individuals from three cohorts. GWAS of lower body strength was also characterized in a subset of cohorts. Two genomewide significant (P-value< 5 × 10(-8) ) and 39 suggestive (P-value< 5 × 10(-5) ) associations were observed from meta-analysis of the discovery cohorts. After meta-analysis with replication cohorts, genomewide significant association was observed for rs752045 on chromosome 8 (β = 0.47, SE = 0.08, P-value = 5.20 × 10(-10) ). This SNP is mapped to an intergenic region and is located within an accessible chromatin region (DNase hypersensitivity site) in skeletal muscle myotubes differentiated from the human skeletal muscle myoblasts cell line. This locus alters a binding motif of the CCAAT/enhancer-binding protein-β (CEBPB) that is implicated in muscle repair mechanisms. GWAS of lower body strength did not yield significant results. A common genetic variant in a chromosomal region that regulates myotube differentiation and muscle repair may contribute to variability in grip strength in the elderly. Further studies are needed to uncover the mechanisms that link this genetic variant with muscle strength.
Indexed as
Genome-Wide Association StudyAdultAgedChromatin ImmunoprecipitationCohort StudiesEpigenesis, GeneticHand StrengthHumansMolecular Sequence AnnotationMuscle StrengthPolymorphism, Single NucleotideQuantitative Trait LociReproducibility of Resultsaginggenomewide associationmeta-analysismuscle strengtholder adultsSNP
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Registered trials
NCT07253714ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.