ArticlePlant molecular biology2016
SUMO proteases ULP1c and ULP1d are required for development and osmotic stress responses in Arabidopsis thaliana.
Article in Plant molecular biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 48 citations in OpenAlex.
- The C-terminal SUMOylation-dependent regulation of αKNL2 governs its centromere targeting and interaction with CENH3.Plant communications · 2026Article
- SIZ1 SUMOylates and stabilizes WRI1 to safeguard seed filling and fatty acid biosynthesis under high-temperature stress.The Plant cell · 2025Article
- Identification and characterization of novelPeerJ · 2025Article
- Plants' Physio-Biochemical and Phyto-Hormonal Responses to Alleviate the Adverse Effects of Drought Stress: A Comprehensive Review.Plants (Basel, Switzerland) · 2022Review
- Current perspectives of ubiquitination and SUMOylation in abiotic stress tolerance in plants.Frontiers in plant science · 2022Review
- Article
- Plant protease as regulator and signaling molecule for enhancing environmental stress-tolerance.Plant cell reports · 2021Review
- The converging path of protein SUMOylation in phytohormone signalling: highlights and new frontiers.Plant cell reports · 2021Review
- SUMO mediated regulation of transcription factors as a mechanism for transducing environmental cues into cellular signaling in plants.Cellular and molecular life sciences : CMLS · 2021Review
- An Insight into the Factors Influencing Specificity of the SUMO System in Plants.Plants (Basel, Switzerland) · 2020Review
- The Role of Proteases in Determining Stomatal Development and Tuning Pore Aperture: A Review.Plants (Basel, Switzerland) · 2020Review
- SUMOylation in fungi: A potential target for intervention.Computational and structural biotechnology journal · 2020Review
- PERPETUAL FLOWERING2 coordinates the vernalization response and perennial flowering in Arabis alpina.Journal of experimental botany · 2019Article
- Dealing With Stress: A Review of Plant SUMO Proteases.Frontiers in plant science · 2019Review
- Revised nomenclature and functional overview of the ULP gene family of plant deSUMOylating proteases.Journal of experimental botany · 2018Article
- Arabidopsis thaliana SPF1 and SPF2 are nuclear-located ULP2-like SUMO proteases that act downstream of SIZ1 in plant development.Journal of experimental botany · 2018Article
- Exploiting protein modification systems to boost crop productivity: SUMO proteases in focus.Journal of experimental botany · 2018Article
- Fifty shades of SUMO: its role in immunity and at the fulcrum of the growth-defence balance.Molecular plant pathology · 2018Review
- Overexpression of the rice gene OsSIZ1 in Arabidopsis improves drought-, heat-, and salt-tolerance simultaneously.PloS one · 2018Article
- Post-translational modifications of Arabidopsis E3 SUMO ligase AtSIZ1 are controlled by environmental conditions.FEBS open bio · 2017Article
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Authors and funding
11 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sumoylation is an essential post-translational regulator of plant development and the response to environmental stimuli. SUMO conjugation occurs via an E1-E2-E3 cascade, and can be removed by SUMO proteases (ULPs). ULPs are numerous and likely to function as sources of specificity within the pathway, yet most ULPs remain functionally unresolved. In this report we used loss-of-function reverse genetics and transcriptomics to functionally characterize Arabidopsis thaliana ULP1c and ULP1d SUMO proteases. GUS reporter assays implicated ULP1c/d in various developmental stages, and subsequent defects in growth and germination were uncovered using loss-of-function mutants. Microarray analysis evidenced not only a deregulation of genes involved in development, but also in genes controlled by various drought-associated transcriptional regulators. We demonstrated that ulp1c ulp1d displayed diminished in vitro root growth under low water potential and higher stomatal aperture, yet leaf transpirational water loss and whole drought tolerance were not significantly altered. Generation of a triple siz1 ulp1c ulp1d mutant suggests that ULP1c/d and the SUMO E3 ligase SIZ1 may display separate functions in development yet operate epistatically in response to water deficit. We provide experimental evidence that Arabidopsis ULP1c and ULP1d proteases act redundantly as positive regulators of growth, and operate mainly as isopeptidases downstream of SIZ1 in the control of water deficit responses.
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