ReviewAnnals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc2016
Electrocardiographic Presentation, Cardiac Arrhythmias, and Their Management in β-Thalassemia Major Patients.
Review in Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 37 citations in OpenAlex.
- Article
- Multimodal evidence chain of iron overload, inflammation, and dysfunction: an integrated predictive model of early cardiac injury in pediatric transfusion-dependentFrontiers in cardiovascular medicine · 2026Article
- Cardiac Dysfunction in β-Thalassemia: A Narrative Review.Research in heart yield and translational medicine · 2025Review
- Antioxidative effects of N-acetylcysteine in patients with β-thalassemia: A quick review on clinical trials.Health science reports · 2024Article
- Association Between β-thalassemia and Atrial Fibrillation: Insights from the United States National Inpatient Sample.The Journal of innovations in cardiac rhythm management · 2023Article
- Article
- Electrophysiological properties and heart rate variability of patients with thalassemia major in Jakarta, Indonesia.PloS one · 2023Article
- Atrial Fibrillation in β-Thalassemia: Overview of Mechanism, Significance and Clinical Management.Biology · 2022Review
- Genotypic groups as risk factors for cardiac magnetic resonance abnormalities and complications in thalassemia major: a large, multicentre study.Blood transfusion = Trasfusione del sangue · 2021Article
- Evolution of electrocardiographic abnormalities and arrhythmias in adult patients with beta-thalassemia major during a short-term follow-up.American journal of cardiovascular disease · 2021Article
- Left Atrial Strain Identifies Increased Atrial Ectopy in Patients with Beta-Thalassemia Major.Diagnostics (Basel, Switzerland) · 2020Article
- Twelve-lead and signal-averaged electrocardiographic parameters among beta-thalassemia major patients.Journal of arrhythmia · 2020Article
- The Role of Heart Rate Variability and Fragmented QRS for Determination of Subclinical Cardiac Involvement in Beta-Thalassemia Major.Pulse (Basel, Switzerland) · 2020Article
- Atrial fibrillation in β-thalassemia patients with a focus on the role of iron-overload and oxidative stress: A review.Journal of cellular physiology · 2019Review
- Iron overload and arrhythmias: Influence of confounding factors.Journal of arrhythmia · 2019Review
- Economic Evaluation of Chelation Regimens for β-Thalassemia Major: a Systematic Review.Mediterranean journal of hematology and infectious diseases · 2019Review
- Arrhythmias and Sudden Cardiac Death in Beta-Thalassemia Major Patients: Noninvasive Diagnostic Tools and Early Markers.Cardiology research and practice · 2019Review
- Cardiac complications in beta-thalassemia: From mice to men.Experimental biology and medicine (Maywood, N.J.) · 2017Review
- Relationship between Hepatitis C Virus Infection and Iron Overload.Chinese medical journal · 2017Review
- The role of the atrial electromechanical delay in predicting atrial fibrillation in beta-thalassemia major patients.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Beta-thalassemia major (β-TM) is a genetic hemoglobin disorder characterized by an absent synthesis of globin chains that are essential for hemoglobin formation, causing chronic hemolytic anemia. Clinical management of thalassemia major consists in regular long-life red blood cell transfusions and iron chelation therapy to remove iron introduced in excess with transfusions. Iron deposition in combination with inflammatory and immunogenic factors is involved in the pathophysiology of cardiac dysfunction in these patients. Heart failure and arrhythmias, caused by myocardial siderosis, are the most important life-limiting complications of iron overload in beta-thalassemia patients. Cardiac complications are responsible for 71% of global death in the beta-thalassemia major patients. The aim of this review was to describe the most frequent electrocardiographic abnormalities and arrhythmias observed in β-TM patients, analyzing their prognostic impact and current treatment strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.