SynthesisNeuropsychology review2016
Social Cognition in Multiple Sclerosis: a Meta-Analysis.
Synthesis in Neuropsychology review, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 3 syntheses or guidelines pooled it, 83 citations in OpenAlex.
- Association between emotion recognition and cognitive functioning in multiple sclerosis: a multilevel correlational meta-analysis.Scientific reports · 2026Pooled it
- A systematic review and meta-analysis of socio-cognitive impairments in multiple sclerosis.Scientific reports · 2024Pooled it
- Empathy and Theory of Mind in Multiple Sclerosis: A Meta-Analysis.Frontiers in psychiatry · 2021Pooled it
- Impact of mindfulness training on emotion regulation in multiple sclerosis: Secondary analysis of a pilot randomized controlled trial.Rehabilitation psychology · 2022Trial
- Preservation of positive emotion recognition in patients with multiple sclerosis: Artefact related to methodological issues or real feature of the disorder?Journal of neuropsychology · 2026Article
- A novel ecological approach to assess theory of Mind and social norm understanding for social cognition phenotyping in multiple sclerosis.Scientific reports · 2026Article
- Beyond Physical Disability: The Social Cognition Challenges in Quality of Life Among Multiple Sclerosis Patients.Healthcare (Basel, Switzerland) · 2025Article
- Exploring Social Cognition Sub-Domains and Predictors in Multiple Sclerosis: A Cross-Sectional Study.Brain and behavior · 2025Article
- Cognitive and affective theory of mind in young and elderly patients with multiple sclerosis.Journal of neuropsychology · 2025Article
- Mentalizing self mind but not others: Self-reported mentalization difficulties in multiple sclerosis.Brain and behavior · 2024Article
- Observational
- Relationship between emotion recognition and cognition in multiple sclerosis: a meta-analysis protocol.BMJ neurology open · 2024Article
- Pyruvate Dehydrogenase-Dependent Metabolic Programming Affects the Oligodendrocyte Maturation and Remyelination.Molecular neurobiology · 2024Article
- Social Cognition Impairments in Association to Clinical, Cognitive, Mood, and Fatigue Features in Multiple Sclerosis: A Study Protocol.Neurology international · 2023Article
- Cerebral response to emotional working memory based on vocal cues: an fNIRS study.Frontiers in human neuroscience · 2023Article
- A cultural training for the improvement of cognitive and affective Theory of Mind in people with Multiple Sclerosis: a pilot randomized controlled study.Frontiers in psychology · 2023Article
- Emotional Recognition and Its Relation to Cognition, Mood and Fatigue in Relapsing-Remitting and Secondary Progressive Multiple Sclerosis.International journal of environmental research and public health · 2022Article
- Masked face recognition in patients with relapsing-remitting multiple sclerosis during the ongoing COVID-19 pandemic.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Article
- "What Is Hidden behind the Mask?" Facial Emotion Recognition at the Time of COVID-19 Pandemic in Cognitively Normal Multiple Sclerosis Patients.Diagnostics (Basel, Switzerland) · 2021Article
- Social Cognition in Multiple Sclerosis: A 3-Year Follow-Up MRI and Behavioral Study.Diagnostics (Basel, Switzerland) · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multiple sclerosis (MS) is associated with cognitive decline and impairment in social functioning. Accumulating evidence suggests that patients with MS are impaired in social cognition, including theory of mind (ToM) and emotion recognition. In this meta-analysis of 24 studies, facial emotion recognition and ToM performances of 989 patients with MS and 836 healthy controls were compared. MS was associated with significant impairments with medium effect sizes in ToM (d = 0.57) and facial emotion recognition (d = 0.61). Among individual emotions recognition of fear and anger were particularly impaired. The severity of social cognitive deficits was significantly associated with non-social cognitive impairment. These deficits in social cognition may underpin difficulties in social functioning in MS. However, there is a need for further studies investigating the longitudinal evolution of social cognitive deficits and their neural correlates in MS.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.