Trial reportInternational journal of biometeorology2016
Effects of sulfur bath on hip osteoarthritis: a randomized, controlled, single-blind, follow-up trial: a pilot study.
Trial report in International journal of biometeorology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 6 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Evidence-based balneotherapy in Hungary. Updated systematic review and meta-analysis of the Hungarian clinical trials.International journal of biometeorology · 2026Pooled it
- Efficacy and safety of balneotherapy in rheumatology: a systematic review and meta-analysis.BMJ open · 2025Pooled it
- Balneotherapy for osteoarthritis: a systematic review.Rheumatology international · 2023Pooled it
- Pooled it
- The role of mineral elements and other chemical compounds used in balneology: data from double-blind randomized clinical trials.International journal of biometeorology · 2017Pooled it
- EQ-5D studies in musculoskeletal and connective tissue diseases in eight Central and Eastern European countries: a systematic literature review and meta-analysis.Rheumatology international · 2017Pooled it
- Does balneotherapy provide additive effects to physical therapy in patients with subacute supraspinatus tendinopathy? A randomized, controlled, single-blind study.International journal of biometeorology · 2021Trial
- Spa therapy adjunct to pharmacotherapy is beneficial in rheumatoid arthritis: a crossover randomized controlled trial.International journal of biometeorology · 2018Trial
- Effectiveness and Safety of Mud Therapy (Pelotherapy) for Musculoskeletal Disorders: A Systematic Review and Meta-Analysis.Journal of lifestyle medicine · 2026Review
- Natural Sulfur Compounds in Mineral Waters: Implications for Human Health and Disease.International journal of molecular sciences · 2025Review
- Challenges of blinding in clinical balneology trials: a scoping review.BMC complementary medicine and therapies · 2025Article
- The Potential Role of Spa Therapy in Managing Frailty in Rheumatic Patients: A Scoping Review.Healthcare (Basel, Switzerland) · 2023Article
- Characteristics of patients with knee and/or hip osteoarthritis undergoing spa treatment: the prospective KHOALA cohort study.International journal of biometeorology · 2022Article
- Sulfurous-arsenical-ferruginous balneotherapy for osteoarthritis of the hand: results from a retrospective observational study.International journal of biometeorology · 2020Observational
- Spa therapy and rehabilitation of musculoskeletal pathologies: a proposal for best practice in Italy.International journal of biometeorology · 2020Article
- Hydrogen sulfide biosynthesis is impaired in the osteoarthritic joint.International journal of biometeorology · 2020Article
- Effect of balneotherapy in sulfurous water on an in vivo murine model of osteoarthritis.International journal of biometeorology · 2020Article
- A Qualitative Study of Patients' Beliefs and Perception on Medicinal Properties of Natural Hot Spring Bath for Musculoskeletal Problems.Journal of environmental and public health · 2020Article
- Outpatient balneological treatment of osteoarthritis in older persons : A retrospective study.Zeitschrift fur Gerontologie und Geriatrie · 2019Observational
- Investigation of Lake Hévíz Mineral Water Balneotherapy and Hévíz Mud Treatment in Murine Osteoarthritis and Rheumatoid Arthritis Models.Evidence-based complementary and alternative medicine : eCAM · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effects of balneotherapy were evaluated in patients with osteoarthritis of the hip. This randomized, controlled, investigator-blinded study enrolled outpatients with hip osteoarthritis according to ACR criteria. In addition to home exercise therapy, one patient group received balneotherapy for 3 weeks on 15 occasions. The mineral water used in this study is one of the mineral waters with the highest sulfide ion content (13.2 mg/L) in Hungary. The control group received exercise therapy alone. The WOMAC Likert 3.1 index and the EQ-5D quality of life self-administered questionnaire were completed three times during the study: prior to first treatment, at the end of the 3-week treatment course, and 12 weeks later. The main endpoint was achievement of Minimal Clinically Important Improvement (MCII) at 12 weeks, defined as ≥7.9 points in a normalized WOMAC function score. The intention to treat analysis included 20 controls and 21 balneotherapy patients. At 12 weeks, 17 (81 %) balneotherapy group patients had Minimal Clinically Important Improvement and 6 (30 %) of controls (p = 0.001). Comparing the results of the two groups at the end of treatment, there was a significant difference in the WOMAC stiffness score only, whereas after 12 weeks, the WOMAC pain, stiffness, function, and total scores also showed a significant difference in favor of the balneotherapy group. The difference between the two groups was significant after 12 weeks in point of EQVAS score, too. The results of our study suggest that the combination of balneotherapy and exercise therapy achieves more sustained improvement of joint function and decreases in pain than exercise therapy alone.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.