Evidence map›Paper›PMID 27324836›Full record

ArticleeLife2016

Admixture into and within sub-Saharan Africa.

George Bj Busby, Gavin Band, Quang Si Le, Muminatou Jallow, Edith Bougama, Valentina D Mangano, Lucas N Amenga-Etego, Anthony Enimil, Tobias Apinjoh, Carolyne M Ndila and 7 more

Abstract read
In one paragraph

Article in eLife, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
89citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

89 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Genomic origin ofHorticulture research · 2025
    Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. FGFR2 genetic variants in women with breast cancer.Molecular medicine reports · 2023
    Article

29 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

George Bj BusbyWellcome Trust Centre for Human Genetics, Oxford, United Kingdom.ORCID 0000-0003-4148-6222
Gavin BandWellcome Trust Centre for Human Genetics, Oxford, United Kingdom.
Quang Si LeWellcome Trust Centre for Human Genetics, Oxford, United Kingdom.
Muminatou JallowMedical Research Council Unit, Serrekunda, The Gambia.
Edith BougamaCentre National de Recherche et de Formation sur le Paludisme, Ouagadougou, Burkina Faso.
Valentina D ManganoDipartimento di Sanita Publica e Malattie Infettive, University of Rome La Sapienza, Rome, Italy.
Lucas N Amenga-EtegoNavrongo Health Research Centre, Navrongo, Ghana.
Anthony EnimilKomfo Anokye Teaching Hospital, Kumasi, Ghana.
Tobias ApinjohDepartment of Biochemistry and Molecular Biology, University of Buea, Buea, Cameroon.
Carolyne M NdilaKEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.
Alphaxard ManjuranoJoint Malaria Programme, Kilimanjaro Christian Medical College, Moshi, Tanzania.
Vysaul NyirongoMalawi-Liverpool Wellcome Trust Clinical Research Programme, College of Medicine, University of Malawi, Blantyre, Malawi.
Ogobara DoumbaMalaria Research and Training Centre, University of Bamako, Bamako, Mali.
Kirk A RockettWellcome Trust Centre for Human Genetics, Oxford, United Kingdom.ORCID 0000-0002-6369-9299
Dominic P KwiatkowskiWellcome Trust Centre for Human Genetics, Oxford, United Kingdom.
Chris Ca SpencerWellcome Trust Centre for Human Genetics, Oxford, United Kingdom.
Malaria Genomic Epidemiology Network

Funding

Medical Research Council G0600718Medical Research Council MC_UP_A900_1118Medical Research Council MR/M006212/1Wellcome Trust 077383Wellcome Trust 084538Wellcome Trust 090532Wellcome Trust 090770Wellcome Trust 097364Wellcome Trust 098051
6 · The paper itself

Abstract

Similarity between two individuals in the combination of genetic markers along their chromosomes indicates shared ancestry and can be used to identify historical connections between different population groups due to admixture. We use a genome-wide, haplotype-based, analysis to characterise the structure of genetic diversity and gene-flow in a collection of 48 sub-Saharan African groups. We show that coastal populations experienced an influx of Eurasian haplotypes over the last 7000 years, and that Eastern and Southern Niger-Congo speaking groups share ancestry with Central West Africans as a result of recent population expansions. In fact, most sub-Saharan populations share ancestry with groups from outside of their current geographic region as a result of gene-flow within the last 4000 years. Our in-depth analysis provides insight into haplotype sharing across different ethno-linguistic groups and the recent movement of alleles into new environments, both of which are relevant to studies of genetic epidemiology.

Indexed as

Black PeopleGenome, HumanHuman MigrationAfrica South of the SaharaGene FlowGenetic VariationHaplotypesHumansadmixtureAfricachromosome paintingevolutionary biologygene-flowgenomicshuman

Identifiers

PMID27324836
PMCPMC4915815

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.