SynthesisAnnals of biomedical engineering2017
3D Printing of Calcium Phosphate Ceramics for Bone Tissue Engineering and Drug Delivery.
Synthesis in Annals of biomedical engineering, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 102 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
102 citing papers in PubMed.
- 3D-Printed Vancomycin- and Gentamicin-Loaded Bone Grafts for Osteomyelitis Treatment: Drug Release and Antibacterial Efficacy.ACS omega · 2026Article
- Comprehensive Toxicological Evaluation of 3D-Printed Hydroxyapatite (3DPHA) for Bone Grafting Applications.International journal of molecular sciences · 2026Article
- Ultra-Short Peptide Hydrogels as 3D Bioprinting Materials.Gels (Basel, Switzerland) · 2026Review
- Precision immunopharmacology in peri-implantitis management: from molecular mechanisms to advanced therapeutic strategies.Frontiers in immunology · 2026Review
- Microfluidic synthesis of alumina particle-laden beads via capillary number tuning for varying particle concentrations.Microfluidics and nanofluidics · 2026Article
- 3D Printed Patient-Specific Resorbable Bone Scaffolds for Alveolar Bone Regeneration.Tissue engineering and regenerative medicine · 2026Review
- Bone regenerative efficacy of binder-jet fabricated hydroxyapatite granules with and without biomimetic octacalcium phosphate-coated modification in a rat critical-sized calvarial defect model.Regenerative biomaterials · 2026Article
- Three-Dimensional Printing of Calcium Phosphate-Mesoporous Bioactive Glass Scaffolds for Bone Tissue Engineering.Journal of functional biomaterials · 2025Article
- The Impact of Post-Printing Hydration in NaCl Solution on the Properties of Binder Jet 3D-Printed Calcium Sulfate and Its Converted Hydroxyapatite.Journal of functional biomaterials · 2025Article
- Dose-dependent osteoimmunomodulatory effects of amorphous calcium phosphate nanoparticles promote 3D-printed scaffold-mediated bone regeneration.Bioactive materials · 2025Article
- Calcium Phosphate Honeycomb Scaffolds with Tailored Microporous Walls Using Phase Separation-Assisted Digital Light Processing.Materials (Basel, Switzerland) · 2025Article
- Development and Comparison of Two 3D-Printed Scaffolds of Biosilica from Marine Sponges for Bone Tissue Engineering.ACS omega · 2025Article
- Gingerol-zinc complex loaded 3D-printed calcium phosphate for controlled release application.Drug delivery and translational research · 2025Article
- Bioactive Inorganic Materials for Innervated Multi-Tissue Regeneration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Global Advancements in Bioactive Material Manufacturing for Drug Delivery: A Comprehensive Study.ACS omega · 2025Article
- A Systematic Review of the Contribution of Additive Manufacturing toward Orthopedic Applications.ACS omega · 2024Review
- Personalized bioceramic grafts for craniomaxillofacial bone regeneration.International journal of oral science · 2024Review
- Development of Bioinspired Biphasic Calcium Phosphate Inks for Manufacturing Bone Scaffolds by Robocasting.3D printing and additive manufacturing · 2024Article
- Silica 3D printed scaffolds as pH stimuli-responsive drug release platform.Materials today. Bio · 2024Article
- Article
42 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Additive manufacturing, also known as 3D printing, has emerged over the past 3 decades as a disruptive technology for rapid prototyping and manufacturing. Vat polymerization, powder bed fusion, material extrusion, and binder jetting are distinct technologies of additive manufacturing, which have been used in a wide variety of fields, including biomedical research and tissue engineering. The ability to print biocompatible, patient-specific geometries with controlled macro- and micro-pores, and to incorporate cells, drugs and proteins has made 3D-printing ideal for orthopaedic applications, such as bone grafting. Herein, we performed a systematic review examining the fabrication of calcium phosphate (CaP) ceramics by 3D printing, their biocompatibility in vitro, and their bone regenerative potential in vivo, as well as their use in localized delivery of bioactive molecules or cells. Understanding the advantages and limitations of the different 3D printing approaches, CaP materials, and bioactive additives through critical evaluation of in vitro and in vivo evidence of efficacy is essential for developing new classes of bone graft substitutes that can perform as well as autografts and allografts or even surpass the performance of these clinical standards.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.