ArticleJapanese journal of ophthalmology2016
Age-related differences in corneal epithelial thickness measurements with anterior segment optical coherence tomography.
Article in Japanese journal of ophthalmology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 43 citations in OpenAlex.
- Evaluation of epithelial, stromal, and corneal thickness maps in the distinction between pellucid marginal degeneration and inferior keratoconus (pellucid-like).BMC ophthalmology · 2026Article
- Discrepancy Between Preoperative and Intraoperative Central Corneal Epithelial Thickness During Alcohol-Assisted PRK.Journal of ophthalmology · 2026Article
- Investigation of postmortem change in the human corneal epithelium via impression cytology.Scientific reports · 2025Article
- Effect of lid-wiper epitheliopathy on the corneal epithelial thickness distribution: a novel semiautomatic quantitative method.BMC ophthalmology · 2025Article
- Repeatability of Corneal Epithelial Thickness Map Using Anterior-Segment Optical Coherence Tomography in Normal and Corneal Disease Patients.Korean journal of ophthalmology : KJO · 2024Article
- Article
- Blepharoptosis and corneal epithelial thickness alterations, is there any relation?BMC ophthalmology · 2024Article
- Intraoperative variability of corneal epithelium thickness in photorefractive keratectomy.International ophthalmology · 2024Article
- Corneal stromal mapping characteristics in normal corneas using anterior segment SD-OCT.Frontiers in medicine · 2024Article
- Assessment of corneal epithelial thickness mapping by spectral-domain optical coherence tomography.Frontiers in medicine · 2024Article
- Corneal Epithelial Thickness Mapping: A Major Review.Journal of ophthalmology · 2024Review
- Demographics Prediction and Heatmap Generation From OCT Images of Anterior Segment of the Eye: A Vision Transformer Model Study.Translational vision science & technology · 2022Article
- Biometric Determinants of Epithelial Thickness Profile Across a Wide Range of Refractive Errors.Ophthalmology and therapy · 2022Article
- Corneal Epithelial Mapping Characteristics in Normal Eyes Using Anterior Segment Spectral Domain Optical Coherence Tomography.Translational vision science & technology · 2022Article
- A cross-sectional study to compare the normal corneal epithelial thickness in various age groups of Indian population using 9 mm wide optical coherence tomography scans.Indian journal of ophthalmology · 2022Observational
- Wide Corneal Epithelial Thickness Mapping in Eyes With Topical Antiglaucoma Therapy Using Optical Coherence Tomography.Translational vision science & technology · 2022Article
- Predicting demographic characteristics from anterior segment OCT images with deep learning: A study protocol.PloS one · 2022Article
- Age-Related Changes in Corneal Epithelial Thickness Measured with an Ultrasound Pachymeter.Clinical interventions in aging · 2022Article
- Evolution of corneal epithelial remodeling after myopic laserIndian journal of ophthalmology · 2021Article
- Changes in Corneal Epithelial Thickness Induced by Topical Antiglaucoma Medications.Journal of clinical medicine · 2021Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo measure corneal epithelial thickness (CET) in healthy adults and to investigate its variation with age by use of anterior segment optical coherence tomography (OCT).
methodsA total of 210 healthy individuals were enrolled and divided into four, almost equally sized groups on the basis of age: 18-29 years (group 1), 30-44 years (group 2), 45-59 years (group 3), and 60-80 years (group 4). The CET and total corneal thickness in the central area (diameter 6.0 mm) of each patient were obtained by Fourier-domain OCT, and the regional thickness and topographic variability were compared among the age groups. In addition, the correlations between the CET and age, gender, and refractive status were analyzed using partial correlation tests and multiple regression analysis.
resultsThe CET of the central segment (diameter 2 mm) in groups 1, 2, 3, and 4 were 53.74 ± 3.82, 54.48 ± 3.33, 53.89 ± 3.73, and 53.30 ± 3.36 µm, respectively, demonstrating no significant change with age (P = 0.416). In most of the paracentral and all of the midperipheral zones (annuli 2-5 and 5-6 mm from the center, respectively), the CET differed significantly among the four groups. Correlation analysis suggested that the CET is greater in men than in women and that the CET of both the paracentral and the midperipheral zones is inversely correlated with age. Topographic variability was also inversely correlated with age.
conclusionsThe CET became thinner with age in the paracentral and midperipheral zones, while the central CET seems to remain constant. Gender differences should be considered in the assessment of CET.
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