Evidence map›Paper›PMID 27324463›Full record

ArticleEpidemiology and infection2016

Antibiotic-associated diarrhoea in emergency department observation unit patients.

J P Haran, G Wu, V Bucci, A Fischer, L Keang, E W Boyer, P L Hibberd

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epidemiology and infection, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact, top 94% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Contemporary clinical trials communications · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

J P HaranDepartment of Emergency Medicine,University of Massachusetts Medical School,Worcester,MA,USA.
G WuDepartment of Emergency Medicine,University of Massachusetts Medical School,Worcester,MA,USA.
V BucciDepartment of Biology,University of Massachusetts Dartmouth,North Dartmouth,MA,USA.
A FischerDepartment of Emergency Medicine,University of Massachusetts Medical School,Worcester,MA,USA.
L KeangDepartment of Emergency Medicine,University of Massachusetts Medical School,Worcester,MA,USA.
E W BoyerDepartment of Emergency Medicine,University of Massachusetts Medical School,Worcester,MA,USA.
P L HibberdDepartment of Pediatrics and Division of Global Health,Harvard Medical School,Boston,MA,USA.
University of Massachusetts Chan Medical School · USHarvard University · USUniversity of Massachusetts Dartmouth · US

Funding

Midcareer Investigator Award in Patient-Oriented Research (K24)K24AT003683 · NCCIH · TUFTS MEDICAL CENTER · PI HIBBERD, PATRICIA L · 2006 to 2015
$1.9M
Mentoring in Advanced mHealth Technologies and Machine Learning for HIV/Drug Abuse ResearchK24DA037109 · NIDA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI BOYER, EDWARD W · 2014 to 2025
$1.9M
NCCIH NIH HHS K24 AT003683NIDA NIH HHS K24 DA037109
6 · The paper itself

Abstract

Clostridium difficile diarrhoea is an urgent threat to patients, but little is known about the role of antibiotic administration that starts in emergency department observation units (EDOUs). We studied risk factors for antibiotic-associated diarrhoea (AAD) and C. difficile infection (CDI) in EDOU patients. This prospective cohort study enrolled adult patients discharged after EDOU antibiotic treatment between January 2013 and 2014. We obtained medical histories, EDOU treatment and occurrence of AAD and CDI over 28 days after discharge. We enrolled and followed 275 patients treated with antibiotics in the EDOU. We found that 52 (18·6%) developed AAD and four (1·5%) had CDI. Patients treated with vancomycin [relative risk (RR) 0·52, 95% confidence interval (CI) 0·3-0·9] were less likely to develop AAD. History of developing diarrhoea with antibiotics (RR 3·11, 95% CI 1·92-5·03) and currently failing antibiotics (RR 1·90, 95% CI 1·14-3·16) were also predictors of AAD. Patients with CDI were likely to be treated with clindamycin. In conclusion, AAD occurred in almost 20% of EDOU patients with risk factors including a previous history of diarrhoea with antibiotics and prior antibiotic therapy, while the risk of AAD was lower in patients receiving treatment regimens utilizing intravenous vancomycin.

Indexed as

Drug Resistance, BacterialAdultAgedAnti-Bacterial AgentsClostridioides difficileDiarrheaEmergency Service, HospitalEnterocolitis, PseudomembranousFemaleHumansMaleMassachusettsMiddle AgedProspective StudiesRisk FactorsYoung AdultAnti-Bacterial AgentsAntibioticsClostridium difficilediarrhoeagastrointestinal infectionsinfectious disease

Identifiers

PMID27324463
PMCPMC7495347
OpenAlexW2472742882

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.