ArticleNature communications2016
Faecal bile acids are natural ligands of the mouse accessory olfactory system.
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Transcriptional regulation of the main olfactory epithelium by environmental olfactory exposures.Scientific reports · 2026Article
- Bile acid chemosensation in mammals supports species and gut microbiome evaluation.bioRxiv : the preprint server for biology · 2026Article
- Transcriptional regulation of the main olfactory epithelium by environmental olfactory exposures.bioRxiv : the preprint server for biology · 2026Article
- Combinatorial responsiveness of chemosensory neurons in mouse explants revealed by DynamicNeuroTracker.Cell reports methods · 2025Article
- Article
- Systematic identification of secondary bile acid production genes in global microbiome.mSystems · 2025Article
- Microbiome: A Key Regulator of Body-Brain Interactions.Advances in experimental medicine and biology · 2025Review
- Article
- The influence of olfactory experience on the birthrates of olfactory sensory neurons with specific odorant receptor identities.Genesis (New York, N.Y. : 2000) · 2024Review
- Article
- Type 2 vomeronasal receptor-A4 subfamily: Potential predator sensors in mice.Genesis (New York, N.Y. : 2000) · 2024Review
- Stimulus-Induced Theta-Band LFP Oscillations Format Neuronal Representations of Social Chemosignals in the Mouse Accessory Olfactory Bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Sensing and avoiding sick conspecifics requires Gαi2BMC biology · 2023Article
- Degradation of Bile Acids by Soil and Water Bacteria.Microorganisms · 2021Review
- Do all mice smell the same? Chemosensory cues from inbred and wild mouse strains elicit stereotypic sensory representations in the accessory olfactory bulb.BMC biology · 2021Article
- Coding of pheromones by vomeronasal receptors.Cell and tissue research · 2021Review
- Two highly related odorant receptors specifically detect α-bile acid pheromones in sea lamprey (The Journal of biological chemistry · 2020Article
- Conceptualizing the Vertebrate Sterolbiome.Applied and environmental microbiology · 2020Review
- Paradoxically Sparse Chemosensory Tuning in Broadly Integrating External Granule Cells in the Mouse Accessory Olfactory Bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Physiology-forward identification of bile acid-sensitive vomeronasal receptors.Science advances · 2020Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
The accessory olfactory system (AOS) guides behaviours that are important for survival and reproduction, but understanding of AOS function is limited by a lack of identified natural ligands. Here we report that mouse faeces are a robust source of AOS chemosignals and identify bile acids as a class of natural AOS ligands. Single-unit electrophysiological recordings from accessory olfactory bulb neurons in ex vivo preparations show that AOS neurons are strongly and selectively activated by peripheral stimulation with mouse faecal extracts. Faecal extracts contain several unconjugated bile acids that cause concentration-dependent neuronal activity in the AOS. Many AOS neurons respond selectively to bile acids that are variably excreted in male and female mouse faeces, and others respond to bile acids absent in mouse faeces. These results identify faeces as a natural source of AOS information, and suggest that bile acids may be mammalian pheromones and kairomones.
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