Evidence map›Paper›PMID 27324388›Full record

ArticleNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics2016

CD206-Targeted Liposomal Myelin Basic Protein Peptides in Patients with Multiple Sclerosis Resistant to First-Line Disease-Modifying Therapies: A First-in-Human, Proof-of-Concept Dose-Escalation Study.

Alexey Belogurov, Konstantin Zakharov, Yakov Lomakin, Kirill Surkov, Sergey Avtushenko, Peter Kruglyakov, Ivan Smirnov, Gleb Makshakov, Curtis Lockshin, Gregory Gregoriadis and 3 more

Open access · hybridAbstract readClinical Trial, Phase IMulticenter Study
In one paragraph

Article in Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

  1. Pooled it
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  3. Multiple sclerosis: molecular pathogenesis and therapeutic intervention.Signal transduction and targeted therapy · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Alexey BelogurovM.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
Konstantin ZakharovOJSC Pharmsynthez, St. Petersburg, Russia.
Yakov LomakinM.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
Kirill SurkovOJSC Pharmsynthez, St. Petersburg, Russia.
Sergey AvtushenkoOJSC Pharmsynthez, St. Petersburg, Russia.
Peter KruglyakovOJSC Pharmsynthez, St. Petersburg, Russia.
Ivan SmirnovM.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
Gleb MakshakovCenter of multiple sclerosis and AID of St. Petersburg City Clinical Hospital #31, St. Petersburg, Russia.
Curtis LockshinXenetic Biosciences Inc., Lexington, MA, USA.
Gregory GregoriadisXenetic Biosciences Inc., Lexington, MA, USA.
Dmitry GenkinOJSC Pharmsynthez, St. Petersburg, Russia.
Alexander GabibovM.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia. gabibov@mx.ibch.ru.
Evgeniy EvdoshenkoCenter of multiple sclerosis and AID of St. Petersburg City Clinical Hospital #31, St. Petersburg, Russia.
Kazan Federal University · RUXenetic Biosciences (United States) · USCity Clinical Hospital No 31 · RUFirst Pavlov State Medical University of St. Petersburg · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Previously, we showed that CD206-targeted liposomal delivery of co-encapsulated immunodominant myelin basic protein (MBP) sequences MBP

Indexed as

AdultAntigens, CDCytokinesDisability EvaluationDose-Response Relationship, DrugFemaleFollow-Up StudiesHumansLectins, C-TypeMagnetic Resonance ImagingMaleMannose-Binding LectinsMiddle AgedMultiple SclerosisMyelin Basic ProteinPeptide FragmentsAntigens, CDCD207 protein, humanCytokinesLectins, C-TypeliposomMannose-Binding LectinsMyelin Basic ProteinPeptide FragmentsPhospholipidsClinical trialLiposomesMannoseMRIMyelin basic proteinXemys

Identifiers

PMID27324388
PMCPMC5081122
OpenAlexW2462585679

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.