Evidence map›Paper›PMID 27324359›Full record

ReviewCirculation2016

The Future of Genetics and Genomics: Closing the Phenotype Gap in Precision Medicine.

Calum A MacRae, Ramachandran S Vasan

Abstract readReview
In one paragraph

Review in Circulation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Closing the 'phenotype gap' in precision medicine: improving what we measure to understand complex disease mechanisms.Mammalian genome : official journal of the International Mammalian Genome Society · 2019
    Review
  13. Review
  14. Big data: is clinical practice changing?European heart journal supplements : journal of the European Society of Cardiology · 2019
    Article
  15. Review
  16. Review
  17. Towards Precision in HF Pharmacotherapy.Current heart failure reports · 2017
    Review
  18. Article
  19. Molecular mechanisms in the pathogenesis of arrhythmogenic cardiomyopathy.Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Calum A MacRaeFrom Cardiovascular Division, Brigham and Women's Hospital, Boston, MA (C.A.M.); Department of Medicine, Harvard Medical School, Boston, MA (C.A.M.); Broad Institute of Harvard and MIT, Boston, MA (C.A.M.); National Heart Lung and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA (R.S.V.); Evans Departments of Medicine and Epidemiology, Boston University Schools of Medicine and Public Health, MA (R.S.V.); and Preventive Medicine and Cardiology Sections, Boston University School of Medicine, MA (R.S.V.). camacrae@bics.bwh.harvard.edu.
Ramachandran S VasanFrom Cardiovascular Division, Brigham and Women's Hospital, Boston, MA (C.A.M.); Department of Medicine, Harvard Medical School, Boston, MA (C.A.M.); Broad Institute of Harvard and MIT, Boston, MA (C.A.M.); National Heart Lung and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA (R.S.V.); Evans Departments of Medicine and Epidemiology, Boston University Schools of Medicine and Public Health, MA (R.S.V.); and Preventive Medicine and Cardiology Sections, Boston University School of Medicine, MA (R.S.V.).

Funding

Integration of Whole Genome Sequencing into Clinical MedicineU01HG006500 · NHGRI · BRIGHAM AND WOMEN'S HOSPITAL · PI GREEN, ROBERT C. · 2012 to 2016
$11.5M
Center for Integrated Approaches to Undiagnosed DiseasesU01HG007690 · NHGRI · BRIGHAM AND WOMEN'S HOSPITAL · PI LOSCALZO, JOSEPH · 2014 to 2022
$10.4M
THE FRAMINGHAM HEART STUDY-N01HC25195-268025195-268025195N01HC025195 · HC · TRUSTEES OF BOSTON UNIVERSITY · PI WOLF, PHILIP A · 2002 to 2006
–
NHGRI NIH HHS U01 HG006500NHGRI NIH HHS U01 HG007690NHLBI NIH HHS N01 HC025195
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsBiomedical ResearchCardiologyCardiovascular DiseasesDiffusion of InnovationForecastingGene-Environment InteractionGenetic Predisposition to DiseaseGenetic TherapyGenomicsHumansMolecular Diagnostic TechniquesPhenotypePrecision MedicinePredictive Value of TestsPrognosisgeneticsgenomicsphenotyping

Identifiers

PMID27324359
PMCPMC6188655

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.