ArticleAnnals of dyslexia2016
Anomalous gray matter patterns in specific reading comprehension deficit are independent of dyslexia.
Article in Annals of dyslexia, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Evaluation of Risk of Bias in Neuroimaging-Based Artificial Intelligence Models for Psychiatric Diagnosis: A Systematic Review.JAMA network open · 2023Pooled it
- Understanding the Role of Reading and Oral Language Skills Growth in Overcoming Reading Comprehension Difficulties.Behavioral sciences (Basel, Switzerland) · 2026Article
- Structural Brain Correlates of Poor Reading Comprehension.Neurobiology of language (Cambridge, Mass.) · 2026Article
- Functional connectivity between the uncinate fasciculus and frontotemporal semantic system supports reading comprehension in adolescents.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- From brain to education through machine learning: Predicting literacy and numeracy skills from neuroimaging data.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Sampling inequalities affect generalization of neuroimaging-based diagnostic classifiers in psychiatry.BMC medicine · 2023Article
- Literacy-supporting skills in college students with specific reading comprehension deficit and developmental language disorder.Annals of dyslexia · 2021Article
- The Connectivity Fingerprints of Highly-Skilled and Disordered Reading Persist Across Cognitive Domains.Frontiers in computational neuroscience · 2021Article
- Categorical and Dimensional Diagnoses of Dyslexia: Are They Compatible?Frontiers in psychology · 2020Article
- Effects of SYN1Human brain mapping · 2018Article
- Brain basis of cognitive resilience: Prefrontal cortex predicts better reading comprehension in relation to decoding.PloS one · 2018Article
- A molecular-genetic and imaging-genetic approach to specific comprehension difficulties in children.NPJ science of learning · 2018Article
- Reading Profiles in Multi-Site Data With Missingness.Frontiers in psychology · 2018Article
- The Importance of the Left Occipitotemporal Cortex in Developmental Dyslexia.Current developmental disorders reports · 2018Review
- Neuropsychology of Learning Disabilities: The Past and the Future.Journal of the International Neuropsychological Society : JINS · 2017Review
- Common Brain Structure Findings Across Children with Varied Reading Disability Profiles.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
4 authors.
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Abstract
Specific reading comprehension deficit (SRCD) affects up to 10 % of all children. SRCD is distinct from dyslexia (DYS) in that individuals with SRCD show poor comprehension despite adequate decoding skills. Despite its prevalence and considerable behavioral research, there is not yet a unified cognitive profile of SRCD. While its neuroanatomical basis is unknown, SRCD could be anomalous in regions subserving their commonly reported cognitive weaknesses in semantic processing or executive function. Here we investigated, for the first time, patterns of gray matter volume difference in SRCD as compared to DYS and typical developing (TD) adolescent readers (N = 41). A linear support vector machine algorithm was applied to whole brain gray matter volumes generated through voxel-based morphometry. As expected, DYS differed significantly from TD in a pattern that included features from left fusiform and supramarginal gyri (DYS vs. TD: 80.0 %, p < 0.01). SRCD was well differentiated not only from TD (92.5 %, p < 0.001) but also from DYS (88.0 %, p < 0.001). Of particular interest were findings of reduced gray matter volume in right frontal areas that were also supported by univariate analysis. These areas are thought to subserve executive processes relevant for reading, such as monitoring and manipulating mental representations. Thus, preliminary analyses suggest that SRCD readers possess a distinct neural profile compared to both TD and DYS readers and that these differences might be linked to domain-general abilities. This work provides a foundation for further investigation into variants of reading disability beyond DYS.
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