Evidence map›Paper›PMID 27324337›Full record

Trial reportSurgical endoscopy2017

Prospective randomized controlled trial comparing standard analgesia with combined intra-operative cystic plate and port-site local anesthesia for post-operative pain management in elective laparoscopic cholecystectomy.

Mladjan Protic, Radovan Veljkovic, Anton J Bilchik, Ana Popovic, Milana Kresoja, Aviram Nissan, Itzhak Avital, Alexander Stojadinovic

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Surgical endoscopy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06605235 (The Ideal Local Anesthetic for Intraperitoneal Gallbladder Bed Infiltration Following Laparoscopic Cholecystectomy - a Randomized Controlled Trial), which is not on this map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06605235 nacompletednot on this mapstarted 2024, after this paper: background citation

The Ideal Local Anesthetic for Intraperitoneal Gallbladder Bed Infiltration Following Laparoscopic Cholecystectomy - a Randomized Controlled Trial

TypeinterventionalSponsorPakistan Air Force (PAF) Hospital IslamabadRan2024 to 2024Enrolled90ConditionsCholecystectomy, Laparoscopic, Pain ManagementArmsLocal Anesthesia
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Article
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 4 countries.

Mladjan ProticClinic of Abdominal, Endocrine and Transplantation Surgery, Clinical Center of Vojvodina, Novi Sad, Serbia. mlprotic@gmail.com.
Radovan VeljkovicClinic of Abdominal, Endocrine and Transplantation Surgery, Clinical Center of Vojvodina, Novi Sad, Serbia.
Anton J BilchikUniversity of California Los Angeles, Los Angeles, CA, USA.
Ana PopovicHealth Center "dr Nika Labovic", Berane, Montenegro.
Milana KresojaClinic of Abdominal, Endocrine and Transplantation Surgery, Clinical Center of Vojvodina, Novi Sad, Serbia.
Aviram NissanCalifornia Oncology Research Institute, Santa Monica, CA, USA.
Itzhak AvitalCalifornia Oncology Research Institute, Santa Monica, CA, USA.
Alexander StojadinovicCalifornia Oncology Research Institute, Santa Monica, CA, USA.
Klinički centar Vojvodine · RSUniformed Services University of the Health Sciences · USHadassah Medical Center · ILUniversity of California, Los Angeles · USUniversity of Montenegro · ME

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVarious mechanisms, including somatic and visceral nociceptive stimulation, have been suggested as a cause for pain after laparoscopic cholecystectomy (LC). We therefore conducted a prospective randomized controlled trial (PRCT) to evaluate whether somatovisceral pain blockade reduces pain after LC. HYPOTHESIS: Analgesic efficacy of multimodal analgesia is superior to standard analgesia for patients undergoing elective LC for symptomatic cholelithiasis. Specifically, topical cystic plate and port-site injection with 0.25 % bupivacaine significantly reduces pain after LC.

designThis study was designed as single-blinded PRCT.

settingThis study was conducted in an academic medical center. PATIENTS AND

methodsBetween February and May 2010 we randomly assigned 63 patients with symptomatic cholelithiasis in a 1:1 ratio to non-opioid/opioid analgesic combinations (Control Group, n = 32) and non-opioid/opioid analgesic combinations plus topical 0.25 % bupivacaine onto the cystic plate and local 0.25 % bupivacaine port-site injection, post-LC (Study Group, n = 31). Primary endpoint was patient-reported pain 1, 4, 6, 12, 24 h and 1 week post-LC using the Visual Analog Scale (VAS 0-10).

resultsStudy groups were comparable clinicopathologically. There were no adverse events. A statistically significant reduction in mean pain score was apparent in Study Group patients in comparison with Control Group (mean VAS 4.83 ± 2.33 vs. 6.80 ± 1.87; p < 0.001) at all early (1-6 h) post-operative time points following LC.

conclusionThis PRCT shows significantly improved pain control with somatovisceral pain blockade over non-opioid/opioid analgesic combinations following LC for symptomatic cholelithiasis. For centers not utilizing adjunctive local anesthetic for LC, this topical use of bupivacaine may improve patient comfort during recovery. This trial was registered on www.ClinicalTrials.gov NCT# 01972620.

Indexed as

AdultAgedAnalgesicsAnesthesia, LocalAnesthetics, LocalBupivacaineCholecystectomy, LaparoscopicCholelithiasisDiclofenacDipyroneDouble-Blind MethodElective Surgical ProceduresFemaleHumansInjections, IntraperitonealKetorolacAnalgesicsAnesthetics, LocalBupivacaineDiclofenacDipyroneKetorolacAnalgesiaCholelithiasisGallstonesLaparoscopic cholecystectomyPain

Identifiers

PMID27324337
OpenAlexW2470788496

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.