Evidence map›Paper›PMID 27324320›Full record

Trial reportSpinal cord2017

Targeting inflammation to influence cognitive function following spinal cord injury: a randomized clinical trial.

D J Allison, A R Josse, D A Gabriel, P Klentrou, D S Ditor

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Spinal cord, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

D J AllisonDepartment of Kinesiology, Brock University, St Catharines, Ontario, Canada.
A R JosseDepartment of Kinesiology, Brock University, St Catharines, Ontario, Canada.
D A GabrielDepartment of Kinesiology, Brock University, St Catharines, Ontario, Canada.
P KlentrouDepartment of Kinesiology, Brock University, St Catharines, Ontario, Canada.
D S DitorDepartment of Kinesiology, Brock University, St Catharines, Ontario, Canada.
Brock University · CANiagara Health System · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

STUDY

designThis study was a randomized, parallel-group, controlled clinical trial.

objectivesThe purpose of this study was to examine the efficacy of targeting inflammation as a means of improving cognitive function in individuals with spinal cord injury.

settingParticipants were recruited from the Niagara region of Ontario Canada and all testing occurred on-site at Brock University.

methodsIndices of memory and verbal learning were assessed by means of the California Verbal Learning Test (CVLT). Inflammation and concentrations of neuroactive compounds related to the kynurenine pathway were assessed via a number of pro- and anti-inflammatory cytokines, as well as tryptophan, kynurenine and several large neutral amino acids. All assessments were performed at baseline as well as at 1 month and 3 months during a 3-month intervention by means of an anti-inflammatory diet.

resultsDespite a reduction in inflammation, all measures of the CVLT, including list A, trial 1 (P=0.48), learning slope (P=0.46), long delay free recall (P=0.83), intrusions (P=0.61) and repetitions (P=0.07), showed no significant group × time interaction.

conclusionIt may be possible that the reduction in inflammation achieved in the current study was insufficient to induce substantial changes in indices of verbal learning and memory. Alternatively, as these participants likely underwent years of previous chronic inflammation, the underlying hippocampal damage may have negated potential improvements induced by acute reductions in inflammation.

Indexed as

AdultAgedBiomarkersCognitionFemaleHumansKynurenineLearningMaleMental RecallMiddle AgedNeuroimmunomodulationNeuropsychological TestsSpinal Cord InjuriesTime FactorsTreatment OutcomeBiomarkersKynurenine

Identifiers

PMID27324320
OpenAlexW2464711270

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.